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Dr. Anthony Fauci delivered more good news regarding a potential coronavirus vaccine, indicating some Americans could begin getting vaccinated by the end of this month.During an interview with CNN’s Wolf Blitzer, Fauci, the director of the National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases, said it’s possible a vaccine could begin reaching some Americans by the end of the month, but was confident some would begin getting vaccinated by the end of the year.Fauci’s declaration came on the same day Pfizer said that its Phase 3 vaccine candidate was showing an effectiveness of over 90%. Fauci said the announcement was promising, but a few more questions need to be addressed before it is given approval. Fauci said that things like the vaccine’s durability and effect on the elderly are among concerns that still need to be tackled.“We may have doses that we’re able to give to people by the end of November, beginning of December,” Fauci told CNN’s Blitzer. “Now you have to go through the hoops of making sure all of the I’s are dotted and the T’s are crossed about the safety and regulatory aspects of it, but we would be giving vaccine, very likely, by the end of this year. That is good news.”Last month, the FDA put into place guidelines on approving a vaccine, which was more restrictive than what the White House had hoped for. The FDA noted that a vaccine candidate must be at least 50% effective. Vaccine candidates should include a median follow-up duration of at least two months after completion of the full vaccination regimen to help provide adequate information to assess a vaccine’s risk-benefit.“In addition to outlining our expectations for vaccine sponsors, we also hope the agency's guidance on COVID-19 vaccines helps the public understand our science-based decision-making process that assures vaccine quality, safety and efficacy for any vaccine that is authorized or approved,” Peter Marks, M.D., Ph.D., director of the FDA's Center for Biologics Evaluation and Research, said.While it is possible some will begin getting vaccinated in the coming weeks or months, questions remain on how soon a majority of the country will have the opportunity to become vaccinated. The first Americans slated to become vaccinated will be health care workers and people with a high risk of coronavirus complications, such as the elderly and those living in assisted living facilities, according to an NPR report.Given that Pfizer’s vaccine candidate is showing a high level of effectiveness, Fauci called the development “extraordinary.”"We know there's light at the end of the tunnel, but that doesn't mean that we're going to give up the important public health measures that we continually still have to do every single day,” Fauci said.While there is urgency for both public health and economic reasons for a vaccine, some experts have expressed concern over the speed of a vaccine and whether the expedited timeline is long enough to demonstrate efficacy.Even though a vaccine could be ready by year’s end, trials will be expected to continue for over a year to monitor for possible side effects.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.”Pfizer said based on current projections, it expects to produce globally up to 50 million vaccine doses in 2020 and up to 1.3 billion doses in 2021. 3823

EL CAJON (CNS) - A man who was caught looting homes vacated during the West fire in Alpine in July was sentenced Friday to nearly five years in state prison.Ardian Iseni, 30, was convicted last month of residential burglary and attempted residential burglary.The 500-acre West fire -- which broke out July 6 -- destroyed 34 homes and 21 other buildings and damaged another 20 homes and buildings.RELATED: 412

El Cajon Police continue to search for a wanted suspect while an officer recovers from being dragged down a road by a car. The suspect has been identified as 41-year-old David Pangilinan of Guam. A journalist in Guam said as soon as the news hit on the island that Pangilinan was wanted, everyone instantly recognized the suspect.Related: El Cajon police ID suspect who dragged officer with car“His picture was there and I recognized him right away. He’s a school mate of mine back in elementary and middle school,” said Troy Torres. “Mr. Pangilinan’s family is very well known, a very nice family that has built up businesses a lot over the years, has contributed a lot to the community so his name does stand out,” he said, saying most people on the small island have heard of the family so this news has sparked attention across the island.A press release from El Cajon police said Pangilinan is the suspect in a case that started when an officer stopped to check on an SUV parked illegally and blocking traffic on Washington Avenue in El Cajon. He found a sleeping man and woman inside the car that was later determined to be a rental.The male driver of the car first tried to give false identification then started to put it into gear, so the officer tried to stop him. The officer got trapped in the car and was dragged down the road, then hit by another car. The SUV drove away and was deserted nearby, with the man and woman nowhere to be found. They are still on the loose and El Cajon police are asking for the public to report any information on their whereabouts.The officer is in critical condition as of Monday.A police officer in Guam said they’re on high alert and would know if he tried to return to the island because everyone who lands at the airport in Guam is required to go to a mandatory quarantine facility for six days. Every person is documented before they can leave, so Guam authorities would know if Pangilinan tried to return home.Anyone with information on this incident or the driver and/or passenger is urged to call El Cajon police at 619-579-3311 or San Diego Crime Stoppers at 888-580-8477. 2134

Don't blame Amazon for the death of Toys "R" Us.It's true, online shopping didn't help matters, but the struggles of Toys "R" Us predate the boom in online shopping. Many of its wounds were self-inflicted.The company's biggest problem: It was saddled with billions of dollars in debt. That debt stopped it from making the necessary investment in stores. And that meant an unpleasant shopping experience that doomed the chain. The company told employees Wednesday that it would close or sell its US stores after 70 years in business."If you're going to have that breadth of inventory, you need someone in the store to help you find it, help you experience it," said Greg Portell, lead partner at retail consultant A.T. Kearney. "It's hard to sell toys in a cold, warehouse environment."Even Toys "R" Us CEO David Brandon conceded in an SEC filing last fall that the company had fallen behind competitors "on various fronts, including with regard to general upkeep and the condition of our stores."Toys "R" Us' debt problems date back to well before Amazon was a major threat. Its debt was downgraded to junk bond status in January of 2005, at a time when Amazon's sales were just 4% of their current level.A year later the company was taken private by KKR, Bain Capital and real estate firm Vornado. The .6 billion purchase left it with .3 billion in debt secured by its assets and it never really recovered.The toy store faced several other big challenges at about the same time. There was the rise of big box retailers like Walmart, which now dwarfs Toys "R" Us in total toy sales. Last year toymakers Mattel and Hasbro each sold about billion worth of their toys at Walmart, more than twice as much as what they sold through Toys "R" Us. Target sold just about as many of their as Toys "R" Us last year.And like most retailers, Toys R Us also lost sales to online rivals such as Amazon that offered lower prices and quick shipping.But much of the chain's resources were devoted to paying off that massive debt load rather than staying competitive.When Toys "R" Us filed for bankruptcy in September 2017, it disclosed it had about billion in debt and was spending about 0 million a year just to service that debt.That burden crowded out critical strategic priorities, like making its stores a nice place to shop and paying employees.Tell us: How will you remember Toys 'R' Us?Brandon said in a filing last fall that the bankruptcy process would allow it to invest million in its stores. The company hoped to add playrooms where kids could try out toys and spaces for birthday parties, but it never got the chance.Brandon also vowed to spend more money on staff. With extremely low unemployment, competitors like Walmart are raising wages, while Toys 'R' Us was having trouble attracting the kind of help it needed. It said last fall it would spend million from 2018 to 2021 to raise starting wages and to reward and keep its most effective employees."Better employees make for happier customers," Brandon said in the filing.Despite sharply declining sales, Toys "R" Us was also extremely late to the game in closing stores. At the time of its bankruptcy filing, the chain had 1,697 stores -- more than it had ever had.In January, it announced plans to shut 182 US stores. Last month it filed for the equivalent of bankruptcy for its UK operations, where it had 105 locations. On Wednesday, hours before announcing the decision to close its US operations, it said it would close the last 75 UK stores.But the closings in recent weeks were far too little, too late. And as a result, now all of US stores will close, and probably most foreign stores as well.The-CNN-Wire 3698

During a phone interview with Fox Business on Thursday morning — his first TV interview since contracting COVID-19 — President Donald Trump said that while he hasn't been tested for the virus recently, his health is continuing to improve."I'm essentially very clean," Trump told Fox Business anchor Maria Bartiromo.Trump added that he would be tested again for the virus "very soon" to determine if he's still infected.The President also added that he doesn't "feel" like he could spread the virus to others."No, I don't think I'm contagious. I don't think I'm contagious at all," Trump said.According to the CDC, people infected with COVID-19 can still spread the virus, even if they are asymptomatic. The virus is typically active in humans for about two weeks, though it can last longer.The White House has refused to report when Trump last tested negative for the virus, but Trump announced his positive test on Friday, meaning he may be contagious for about another week.White House chief of staff Mark Meadows said on Wednesday that Trump would like to begin working from the Oval Office and that White House staff would implement safety precautions to make that happen. The CDC recommends those who are infected with the virus remain quarantined.Trump also falsely said Thursday that he's now "immune" to COVID-19."Remember, when you catch it, you get better, and then you're immune, you know?" Trump said. "As soon as everything goes away for me, you're immune."There are several documented cases where people who had previously contracted COVID-19 caught it again — though they suffered less severe symptoms. The CDC says that estimates indicate that COVID-19 antibodies make a person immune for about three months.During his Thursday interview, Trump said he assumed earlier this year that he might catch the virus at some point."But I did look at the numbers say I'll probably catch it, and I'll get better," Trump said. "And that's what happened."Despite the risks, Trump said he needed to continue to face the public because he had to be a "leader." As an example, he said he continued to meet with the families of soldiers who had been killed in action, even though social distancing was not always observed at those ceremonies."They're telling me these stories, and I can't say, 'Back up, stand 10 feet.' I just can't do it. I went through like 35 people and everyone had a different story," Trump said. "They come within an inch of my face sometimes, they want to hug me and they want to kiss me. And they do. I'm not telling them to back up."Trump said Thursday that he believed he contracted the virus at a September ceremony at the White House where he nominated Judge Amy Coney Barrett to the Supreme Court."As far as the White House is concerned, somebody got it in — it was a day of celebration with Notre Dame, etc. etc. Somebody got in and people got infected, whether it was there or something else.," Trump said.Finally, Trump touted the COVID-19 therapeutic drugs he took while in the hospital, falsely calling them "cures." He added that drugs made by Regeneron and Eli Lilly would be granted Emergency Use Authorization (EUA) by the FDA to treat the virus."You take it, and it beats the hell out of it. I'm telling you, I could have walked out of there 24 hours after I went in. I didn't even have to go in, frankly. I think it would have gone away."Trump was referring to REGN-COV2, a monocolonal antibody therapy the clones the strongest antibodies from COVID-19 patients. Regneron formally requested EUA for the drug on Wednesday.Regeneron says it has approximately 50,000 doses of the drug on hand, but could have up to 300,000 doses "within the next few monts," according to CNBC.While the drug has been effective in treating COVID-19, there is no "cure" for the virus. Health experts expect several COVID-19 vaccines to be approved by the end of 2020 and be widely available by the middle of 2021. 3940