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BEIJING, July 26 (Xinhuanet) -- Seven of the 20 top selling American prescription drugs will lose their patents by the end of next year, making way for less expensive generic versions, according to media reports.It's a shift that could save consumers billions of dollars -- assuming those big-ticket medications are willing to give up a trusted brand name for an off-label replacement.The prices of medications such as cholesterol-fighting Lipitor and blood thinner Plavix are expected to go down significantly, according to the U.S. Food and Drug Administration (FDA).Lipitor will lose its patent in November. When that patent expires, people are advised to buy atorvastatin, the generic equivalent. Other brand names include the anti-psychotic Zyprexa and the rheumatoid arthritis and psoriasis drug Enbrel, of which the patent will expire in October and October of next year, respectively.Over the next 10 years, an estimated 120 more brand-name prescription drugs will lose their patents in the U.S.

WASHINGTON, June 6 (Xinhua) -- Women who have higher levels of the appetite-controlling hormone leptin have fewer symptoms of depression, and this apparent inverse relationship is not related to body mass index (BMI), a new study finds. The results were presented Monday at The Endocrine Society's 93rd Annual Meeting in Boston, the United States."Animal data suggest that leptin may reduce anxiety and improve depression. Our study in women suggests that leptin may indeed have antidepressant qualities," said the study's lead author, Elizabeth Lawson, of Massachusetts General Hospital and Harvard Medical School in Boston.Leptin, the product of fat cells, signals satiety, or fullness. It is low in thin women and high in obese women, according to Lawson. She also said there is an increased prevalence of anxiety and depression in certain conditions in which leptin levels are typically low. These include the eating disorder anorexia nervosa, in which there is abnormally low weight and body fat, and functional hypothalamic amenorrhea, in which women have stopped menstruating despite having normal weight."It is unknown whether low leptin levels contribute to the development of mood disorders in these women," Lawson said.She and her co-workers studied the relationship between leptin levels and symptoms of anxiety and depression in 64 women. Fifteen of the women had anorexia nervosa, 12 were normal weight with hypothalamic amenorrhea, 20 were normal weight and in good health, and 17 were overweight or obese but still healthy.All subjects were asked questions to assess symptoms of depression and anxiety, with high scores indicating more symptoms. Besides measuring leptin levels in the blood, the researchers assessed the women's BMI, a measure of weight for height.The relationship between leptin and depression symptoms was independent of BMI. This finding indicates that leptin may mediate symptoms of depression and that this effect is not a function of low weight, Lawson said."Further research administering leptin to humans will be important in understanding whether this hormone has a potential role in the treatment of depression," she said.

WASHINGTON, July 20 (Xinhua) -- Using the Hubble Space Telescope, astronomers have discovered a fourth moon orbiting the icy dwarf planet Pluto, the U.S. National Aeronautics and Space Administration (NASA) announced Wednesday in a statement. The tiny, new satellite, temporarily designated P4, was uncovered in a Hubble survey searching for rings around the dwarf planet.P4 was first seen in a photo taken with Hubble's Wide Field Camera 3 on June 28. It was confirmed in subsequent Hubble pictures taken on July 3 and July 18. It is the smallest moon discovered around Pluto. It has an estimated diameter of 8 to 21 miles (13 to 34 km). By comparison, Charon, Pluto's largest moon, is 648 miles (1,043 km) across, and the other moons, Nix and Hydra, are in the range of 20 to 70 miles in diameter (32 to 113 km).Two labeled images of the Pluto system taken by the Hubble Space Telescope's Wide Field Camera 3 ultraviolet visible instrument with newly discovered fourth moon P4 circled. The image on the left was taken on June 28, 2011. The image of the right was taken on July 3, 2011."I find it remarkable that Hubble's cameras enabled us to see such a tiny object so clearly from a distance of more than 3 billion miles (5 billion km)," said Mark Showalter of the SETI Institute in California, who led this observing program with Hubble.P4 is located between the orbits of Nix and Hydra, which Hubble discovered in 2005. Charon was discovered in 1978 at the U.S. Naval Observatory and first resolved using Hubble in 1990 as a separate body from Pluto.The dwarf planet's entire moon system is believed to have formed by a collision between Pluto and another planet-sized body early in the history of the solar system. The smashup flung material that coalesced into the family of satellites observed around Pluto.The finding is a result of ongoing work to support NASA's New Horizons mission, scheduled to fly through the Pluto system in 2015. The mission is designed to provide new insights about worlds at the edge of our solar system. Hubble's mapping of Pluto's surface and discovery of its satellites have been invaluable to planning for New Horizons' close encounter."This is a fantastic discovery," said New Horizons' principal investigator Alan Stern of the Southwest Research Institute in Colorado. "Now that we know there's another moon in the Pluto system, we can plan close-up observations of it during our flyby."

WASHINGTON, Aug. 16 (Xinhua) -- The White House announced Tuesday that the U.S. Departments of Agriculture, Energy and Navy will invest up to 510 million U.S. dollars in partnership with the private sector to facilitate the country's biofuel industry development."Biofuels are an important part of reducing America's dependence on foreign oil and creating jobs here at home," U.S. President Barack Obama said in a White House statement.The initiative is a response to a directive from Obama issued in March as part of the Blueprint for A Secure Energy Future, the administration's framework for reducing dependence on foreign oil."But supporting biofuels cannot be the role of government alone. That's why we're partnering with the private sector to speed development of next-generation biofuels that will help us continue to take steps towards energy independence and strengthen communities across our country," Obama added.The joint plan calls for the three departments to invest up to 510 million dollars in the next three years, which will require substantial cost share from private industry, in a bid to reduce U. S. reliance on foreign oil and create jobs at home."By building a national biofuels industry, we are creating construction jobs, refinery jobs and economic opportunity in rural communities throughout the country," said U.S. Agriculture Secretary Tom Vilsack.White House figures revealed that the world's largest economy spends more than 300 billion dollars on imported crude oil every year.With a slackening economic recovery and the government's approval rate at a record low level, the Obama administration is rolling out a string of measures in recent days to accelerate economic growth and job creation.

HONG KONG, July 19 (Xinhua) -- A gene controlled by male hormone was critical for the growth of liver tumor, leading to a higher incidence of the disease in men than in women, according to the Chinese University of Hong Kong which made the results public on Tuesday.There is a significant gender bias in liver cancer incidence. In Hong Kong, men are three times more likely to develop liver cancer than women. Such phenomenon prompted researchers from the university to carry out a genomic location analysis in liver cancer cells starting from 2008.The researchers discovered, out of 17,000 human genes, that a gene called Cell Cycle-Related Kinase (CCRK) was directly controlled by androgen receptor. They further found that CCRK was critical for the induction of signaling pathway leading to abnormal liver cell growth and tumor formation.The results also reveal that 70 percent of patients with liver cancer were found to produce high levels of CCRK. More importantly, these patients were more likely to have late-stage cancers and lived shorter than those with low CCRK level.Using mouse models, the researchers found that either lowering the level or blocking the signaling pathway of CCRK in liver cancer cells could significantly reduce the tumor growth rate.The study has validated that CCRK is an important gene that has potential to cause liver cancer and the gene can be tested as a new targeted therapy in future.Vice-Chancellor of the university Joseph Sung, who is also team leader of the research project, said the results explained why men have a higher risk of liver cancer than women and helped push ahead with the development of a novel treatment of the disease.The above study results were published online in July in Journal of Clinical Investigation.