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发布时间: 2025-05-30 06:47:09北京青年报社官方账号
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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

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SAN DIEGO (KGTV) — Cinema and sunsets return to San Diego parks this summer as the county's Summer Movies in the Park program returns.The free outdoor movies every Friday and Saturday come to parks across San Diego County between May and October.Families can enjoy concessions and food trucks at some movie screenings, but should check with the event before heading over. Otherwise, it's the perfect chance to pack a picnic and enjoy a a free movie outdoors.RELATED: Special movies for kids coming to Bonsall's AMC this summerMoving seats, weather effects, scents come to Mira Mesa movie theaterOrganizers recommend showing up early for a good seat as prime viewing for screenings can fill up fast.For a full schedule of movies and where they'll be playing, check out the program's schedule. 802

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SAN DIEGO (KGTV) -- COVID-19 has brought us stories of loss, heartache, and despair. But we've also seen humanity pull together in acts of service and sacrifice.For RN Ana Wilkinson it's a calling born from her childhood, a past not without pain.When Wilkinson arrived in New York City in the midst of the pandemic. She was unprepared for what she witnessed. Put on the floor that night, Wilkinson was given 15 COVID patients. Despite all her efforts, she would lose 8 patients that night. While she says some nurses quit the next day, she decided to stay and "just be Ana." For Ana that meant an unorthodox approach to the sickest patients. She would smile, hold their hands, and dance.Behind her mask of optimism were a lifetime of pain, loss, and sorrow. Something she tries to make better for her patients and their families.At around three years old Ana and her family immigrated to the U.S from Nicaragua as refugees. Childhood was difficult. Her mother's alcoholism would lead to abuse. Abuse and neglect would lead to Ana being put in a foster home. Some days she went to school with bruises.All this Ana says makes her see things differently. She believes it helps her to be more compassionate as a nurse. She is now happily married to a firefighter and has two young boys but volunteering to provide medical care where it's needed is an important part of her life. Whether it's New York City or other countries around the world, Wilkinson answers the call. Always ready to be there in a patient's darkest hours... hoping just maybe her smile can bring light.As part of this story Hunt interviewed Del Mar Clinical Psychologist, and international personality expert, Dr. Richard Levak. Levak has been tasked by American television series such as Survivor, Apprentice, and The Amazing Race to analyze personalities to determine capable candidates and group dynamics. Dr. Levak has never worked with Wilkinson but provided research and analysis. He said the most important thing for all hospitalized COVID patients is not to feel alone. He says what Wilkinson is doing has huge positive affects...saying "it's a wonderful thing that she's doing."Watch the video here. 2183

  

SAN DIEGO (KGTV) — As former San Diego State star Kawhi Leonard readies for his Los Angeles Clippers debut Tuesday, another Aztec will also start the season on an active NBA roster.SDSU's Jalen McDaniels was signed to a multi-year contract and placed on the 17-man roster for the Charlotte Hornets Sunday, the team announced. McDaniels left SDSU after his sophomore season last spring and was picked 52nd overall in the 2019 NBA Draft.The 6-10 forward led the Aztecs in rebound average, total steals, and was second in scoring average last season. McDaniels signed with the Hornets on Oct. 10 under an unguaranteed Exhibit 10 contract, before the team converted it to a two-way contract on Saturday — meaning he could go back and forth between Charlotte's G League-affiliate, Greensboro Swarm, and the NBA. McDaniels participated in two preseason games with the Hornets, averaging 1.0 points and 0.5 rebounds in 5.3 minutes per game, according to the team.Sunday, the team bolstered his contract to a three-year, partially guaranteed contract ahead of the season opener. The terms of the deal were not disclosed.Charlotte's Wednesday night opener against Chicago will also feature two other Mountain West Conference rookies: former University of Nevada, Reno, twins Caleb and Cody Martin, both forwards as well. 1319

  

SAN DIEGO (KGTV) — As San Diego sporting associations work to recruit new officials, they're up against abuse from parents and fans.The problem has gotten so bad that one youth soccer referee created a Facebook page to call out the bad behavior, parent shaming in hopes to address the problem nationwide.Kia Dehpanah has been officiating in San Diego for 25 years. While he does hear complaints from the sideline, he says younger referees deal with it the most.RELATED: Eastlake Little League responds to Park View player eligibility complaint"After a while, these young referees say, 'I don't need this aggravation,'" said Dehpanah.Last year, some youth sports like field hockey and lacrosse had to cancel some games due to not enough referees. These sports face additional recruiting challenges like finding officials who can work early games. There's also a misconception you must have prior knowledge of the sport beforehand."It's not the most glorified profession, it's a tough profession, but I think it has a lot of rewards too," said San Diego CIF Commissioner, Jerry Schniepp.Alicia Oswald, on the San Diego Girl's Lacrosse Umpiring Board, uses officiating as a way to give back to the community. She hopes parents and fans will hear this message so that potential recruits aren't too intimidated to go after the job."We are people too, we are humans," said Oswald. "We are doing our best and our focus is to keep the game safe for the girls."You can learn more about different officiating opportunities here.Girl's lacrosse has an upcoming training session; you can email Oswald for more information: aliciaoswald@gmail.com. 1642

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