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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) -- The majority of residents at Reo Vista Healthcare Center in Paradise Hills have COVID-19, according to officials with the facility.A total of 112 residents have tested positive, according to the facility’s administrator Curtis White. 40 staff members also tested positive for COVID-19. White confirmed 14 residents have passed away. Of that number, five died in local hospitals.The facility holds 135 residents.Juanita Gomez was one of the residents who tested positive. Her son told Team 10 she passed away July 1st.The state strike team assisted in expediting testing for residents and staff, White said. They have visited the facility three times.Cesar Noriega’s 90-year-old mother also tested positive. She is currently in the hospital dealing with COVID-19 and other health related issues. “She’s not doing well. She’s in a lot of pain,” Noriega said. Noriega said he urged early testing at the facility, but his pleas for help went ignored. He is now trying to figure out where his mother can get care after she is released from the hospital.“I’ve gone through elation, through depression, to anger… this is almost on a daily basis,” Noriega said.White said “most of the individuals with COVID are experiencing mild or no symptoms.” 13 residents and 23 staff members have recovered.“Our top priority remains the health and well-being of everyone in our facility,” White said. 1409

SAN DIEGO (KGTV) — The holiday season gets underway this week, as several holiday events head to town.Thanksgiving offers families the chance to run off the turkey before dinner time with several Thanksgiving runs and races around San Diego. For those not planning to cook at home, there are plenty of buffet-style dinners host at local restaurants to enjoy.After Thanksgiving, Liberty Station and Seaport Village start the holidays with a tree lighting and by welcoming Surfin' Santa to town.RELATED:San Diego holiday tree lightings to catch this seasonTurkey trots, holiday runs in San Diego this seasonSkate away on one of San Diego's outdoor ice rinks this holiday seasonChristmas on the Prado also takes over Balboa Park this weekend, while Julian celebrates their own Country Christmas in the mountains.Outside of the holiday fun, the San Diego Jazz Festival brings the smooth, hip, and swaying sounds of music to town for a multi-day festival. And the SoNo Chili Cook-Off pits the area's best cooks head-to-head in a chili showdown.THURSDAYFather Joe's Villages Thanksgiving Day 5K Where: Balboa Park; Cost: - The 18th annual Thanksgiving Day 5K benefits Father Joe's Villages food services program to serve homeless individuals in San Diego. Stick around post race for live music, a beer garden, and Disney character meet-and-greets.MORE Thanksgiving Day races around San DiegoThanksgiving at Bleu Bohème Where: Kensington; Cost: -Enjoy french cuisine this Thanksgiving at Bleu Bohème, where chefs are serving crab croquette, roasted turkey, King salmon, short ribs, fresh beats and more on their menu. Dinners are per person and .95 for children 12 and under.MORE Thanksgiving Day dinners around San DiegoFRIDAYLiberty Station Tree Lighting Where: Liberty Station; Cost: FreeThe holiday fun gets started at 5 p.m. in Liberty Station before the district's 88-foot tree is switched on by a patient family of Rady Children's Hospital. Visitors can enjoy live entertainment, shopping, and outdoor viewing of "How the Grinch Stole Christmas."Surfin Santa at Seaport VillageWhere: Seaport Village; Cost: FreeSurfin' Santa makes his arrival at Seaport Village after the Thanksgiving holiday, sporting his favorite Hawaiian shirt and wet suit. Visitors can pose for free pictures with Santa on his giant surfboard under a six-foot wave. Guests can also enjoy a festive parade on the boardwalk, live street performers, and fun at Seaport's shops.SATURDAYChristmas on the PradoWhere: Balboa Park; Cost: FreeChristmas on the Prado brings tons of Christmas fun to Balboa Park's Organ Pavilion and International Cottages, including holiday kids crafts, photos with Santa, music, delicious seasonal treats, and a tree lighting.Holiday Lights on MainWhere: El Cajon; Cost: FreeDowntown El Cajon is bringing the holidays to Main St. with carnival rides, ice skating, live music, delicious food, and more during Holiday Lights on Main. Visitors can also visit with Santa in his village and check out the grand tree lighting.Julian's Country ChristmasWhere: Julian Pioneer Park; Cost: FreeKick off the holiday season in Julian with sleigh rides, gathered around an open fire, Christmas decorations, and a visit from Santa during a tree lighting ceremony.SUNDAYSoNo Fest & Chili Cook-OffWhere: North Park; Cost: -It's not a "holiday" event, but chili is best enjoyed when its cold outside! The annual cook-off features delicious chili, three stages of live music, and vendors with handmade holiday gifts.Winter Wonderland at the GrandWhere: Fairmont Grand Del Mar; Cost: Free to attend, some attractions cost moneyThe Fairmont Grand Del Mar hosts a free winter wonderland of fun, with a Ferris wheel, carousel, 25-foot tree, photos with Santa, ice skating, or lounging by a fire for some S'mores.San Diego Jazz Fest & Swing ExtravaganzaWhere: Town and Country Resort & Convention Center; Cost: -5(Thursday - Sunday) San Diego celebrates its 40th San Diego Jazz Fest over the Thanksgiving holiday, bringing amazing acts performing traditional jazz, swing, ragtime, and more to San Diego. Guests can take part in dance demonstrations, a swing extravaganza, a "pianorama" and more for jazz fans. 4226

SAN DIEGO (KGTV) - Supporters of Poway Unified School District kicked off a campaign Tuesday night in support of Measure P on the March ballot, which would provide 8 million meant to be spent on facilities across the distict's 39 schools. This is the first time PUSD has asked voters to approve a bond since the infamous "billion dollar bond", which many critics call a debacle which taxpayers will be on the hook for for decades.“We have leaky roofs," Superintendent Marian Kim Phelps told 10News during an interview Tuesday. "We have rusty pipes. We have tile that’s falling apart. We have high schools that have sewage spilling up into the room.” Phelps says a recent study commissioned by the district reported that 63% of the school campuses will be rated in "poor condition" by 2023. She also says a bond is the best option because the state of California does not provide money for facilities.RELATED: Poway Unified brings students together in pilot program with new approach to special education“What most people don’t understand and realize is we don’t receive any funding from the state. And so we also are one of the lowest funded school districts in the county, so we do a lot with a lot less.” Phelps says she understands why taxpayers may be hesitant to fund another bond measure. The last time the district approached voters, the bond was passed by 2011. It was later revealed that because of the way the bond was financed, the 5 million loan would accrue 7 million in interest, meaning taxpayers are on the hook for nearly billion. The bill for that will begin to be paid in 2023 and continue for 40 years.Phelps points out that the entire leadership that approved "the billion dollar bond" has been replaced and that the new team has worked hard to repair Poway Unified's finances in recent years. RELATED: Poway Unified School District implements multi-million dollar plan to improve campus securityShe says the district is being transparent about how this measure will be funded and spent. She also points out that the plan has been endorsed by the San Diego Taxpayers Association.Despite those reassurances, many residents within the district, which is the county's third largest and encompasses the city of Poway and large portions of Inland Northern San Diego, have expressed concern, saying they will not vote for Measure P. The district says polling conducted to gauge community support showed voters marginally in favor of the measure. 2480

SAN DIEGO (KGTV) — The King family, who launched "Chelsea's Light" after the rape and murder of their daughter Chelsea in 2009, has decided to end the popular "Finish Chelsea's Run" event after eight years.In an interview with 10News from the family's home near Chicago, Chelsea's father, Brent, said they are proud of the impact they have been able to have through "Finish Chelsea's Run," but that it was time to move on from the event."Our family wants to thank everybody that has ever come out to run in our race. It's spectacular. It's beautiful. It brings us a lot of joy. But at the same time, it reminds us how we lost our little girl," King said.Chelsea was a 17-year-old student at Poway High in 2010 when she went for a run at Rancho Bernardo Community Park. A registered sex offender, John Gardner, later pleaded guilty to dragging King into a secluded area near Lake Hodges, raping her, and strangling her to death. He buried the body nearby.Shortly after his arrest, Gardner also admitted to the murder of an Escondido teen, Amber DuBois, who had disappeared a year earlier.The King family began the "Chelsea's Light" Foundation, through which it carried out "Finish Chelsea's Run" and a companion baseball tournament. King says "Chelsea's Light" will continue to exist and raise money. However, he has launched a new nationwide organization called "Protect the Joy."King says he will use the experience he gained helping pass "Chelsea's Law" legislation in several states to protect youth from sex offenders to help build a bigger, stronger organization dedicated to issues of defending children."I've built an organization that mirrors the Sierra Club, or the Surfrider Foundation, or Greenpeace. But instead of protecting the trees, or the coastline, or the whales, I'm going to protect our children," King said.For more information on King's new organization, visit the website: ProtecttheJoy.org. 1952

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