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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

LOS ANGELES, April 14 (Xinhua) -- Vegetarians experience a much lower risk of metabolic syndrome than non-vegetarians, U.S. researchers have found.Researchers at Loma Linda University in California based their findings on analysis of more than 700 adults randomly sampled from a long-term study of the lifestyle and health of almost 100,000 Seventh-day Adventist Christians across the United States and Canada.While 25 percent of vegetarians had metabolic syndrome, the number significantly rises to 37 percent for semi-vegetarians and 39 percent for non-vegetarians, according to the study published in the April issue of the journal Diabetes Care.The findings showed that the risk of developing metabolic syndrome is 36 percent lower among vegetarians than non- vegetarians.This means that vegetarians are less likely to develop heart disease, diabetes and stroke -- three major conditions that are closely linked with metabolic syndrome, the researchers say.The study also found that vegetarians, though slightly older than non-vegetarians, had lower triglycerides, glucose levels, blood pressure, waist circumference, and body mass index (BMI). Semi-vegetarians, meanwhile, also had a significantly lower BMI and waist circumference compared to those who ate meat more regularly.The findings will not be affected by other factors such as age, gender, race, physical activity, calories consumed, smoking, and alcohol intake, the researchers say."In view of the high rate of metabolic syndrome in the United States and its deleterious health effects, we wanted to examine lifestyle patterns that could be effective in the prevention and possible treatment of this disorder," says lead researcher Nico S. Rizzo, PhD."I was not sure if there would be a significant difference between vegetarians and non-vegetarians, and I was surprised by just how much the numbers contrast," he says. "It indicates that lifestyle factors such as diet can be important in the prevention of metabolic syndrome."

WINDHOEK, May 21 (Xinhua) -- Top Chinese legislator Wu Bangguo on Saturday met with Namibian President Hifikepunye Pohamba on advancing the bilateral cooperation to further develop the partnership with Namibia.Wu, chairman of the National People's Congress (NPC) Standing Committee, China's top legislative body, extended Chinese President Hu Jintao's greetings to Pohamba and hailed an "all- weather" partnership forged between the two nations.Namibia is one of the youngest states in Africa, which became fully independent in 1990.Wu reviewed the profound friendship between the two countries, which established diplomatic ties one day after Namibia's announcement of its full independence.Wu said the two countries have reaped good harvests in cooperation in the fields of politics, trade, culture, education, public health and culture in recent years, which has already set a model for countries engaged in the South-South cooperation.He also highlighted the mutual understanding and support on issues concerning each other's core interests, and to bring the bilateral economic and trade cooperation to a new high, Wu put forward a three-point proposal concerning the importation of the husbandry and aquatic products, resource and mining as well as the infrastructure construction.Namibia is a nation with significant influence in the southern Africa, Wu said, vowing that China will work with the Namibian side to push the bilateral partnership to a higher level.For his part, Pohamba welcomed Wu's visit, the first one ever paid by a Chinese top legislator, and spoke highly of China's long-standing support for Namibia's national liberation and construction.Namibia will develop the long-term and strategic cooperation in a much broader domain with China and welcomes more Chinese businesses to invest in the country, the Namibian president said.On the China-Afrcia relationship, the two leaders stressed that the two sides should work closer under the framework of the Forum of China-Africa Cooperation to boost political mutual trust, substantial and pragmatic cooperation on trade and humanitarian exchanges, especially those among the young generations, so as to further enrich a new China-Africa partnership.Namibia is the first leg of Wu's 12-day African-Asian tour. He will also visit Angola, South Africa and Maldives.

VIENNA, April 12 (Xinhua) -- A protein group has been identified as an "allergy multiplier" that causes food allergy, a symptom that could also accompany other allergies and produce serious consequences, Austrian researchers said Tuesday.The so-called non-specific lipid transfer proteins (nsLTP) are believed to be the causes of food allergy, a research team from the Medical University of Vienna said in a new report.These plant allergens are found not only in many fruits and vegetables, but also in cereals and some types of pollen. Due to their compact structures, they are not degraded in the gastrointestinal tract and can trigger immune reactions that cause severe allergic symptoms, said the report.The researchers believe that with nsLTP identified as an " allergy multiplier," diagnostic and treatment procedures could be adapted and improved.

LOS ANGELES, May 8 (Xinhua) -- Kids born in the spring and summer months might be more likely to develop celiac disease, U.S. researchers have found.Researchers from the Massachusetts General Hospital for Children drew the conclusion after examining data on 382 children diagnosed with celiac disease at between 11 months and 19 years of age, HealthDay News reported on Sunday.The study found that in the 15- to 19-year-old set, birth season appeared to make no difference, but among 317 children younger than 15 years of age, 57 percent were born in the "light" season of March through August, compared with 43 percent who were born in the "dark" season of September through February.The findings suggest that the higher incidence of this autoimmune disease may be related to a combination of seasonal and environmental factors, the report said.Celiac disease is a digestive disorder triggered by consuming the protein gluten, which is primarily found in bread and other foods containing wheat, barley or rye. It can damage the small intestine and make it difficult to absorb certain nutrients, causing problems ranging from abdominal pain to nerve damage.Even though the exact cause of celiac disease is unknown, potential triggers include the timing of infants' introduction to gluten, and viral infections contracted during the first year of life.The study's findings suggest the season of a child's birth is another potential risk factor for the disease.The researchers pointed out that infants are generally introduced to solid foods containing gluten at around six months of age, which for spring and summer babies would coincide with cold and flu season.Based on the findings, the age at which gluten is first offered to some babies may need to be altered, said the study's lead researcher, Dr. Pornthep Tanpowpong. "If you're born in the spring or the summer, it might not be appropriate to introduce gluten at the same point as someone born in the fall or winter," said Tanpowpong. "Although we need to further develop and test our hypothesis, we think it provides a helpful clue for ongoing efforts to prevent celiac disease."The study also noted that exposure to sunlight may also play a role in celiac disease, since vitamin D deficiency has been associated with the disease.The study was presented Sunday in Chicago during Digestive Disease Week, an international gathering sponsored by the American Gastroenterological Association and other organizations, HealthDay News said.Because the study was presented at a medical meeting and is small, its findings should be considered preliminary until published in a peer-reviewed journal and confirmed in other research, the report said.