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There won't be any drive-thrus at 300-350 new Taco Bell locations, but there will be booze.The Tex-Mex food restaurant is looking to open cantinas across the country that are appealing in urban areas. (There will be 50 new locations added just in Manhattan in New York, according to FoodandWine.com.)GALLERY: What Taco Bell's new 'cantina' restaurants might look likeTaco Bell is targeting millennials moving to downtown areas, and it will offer alcohol at its cantina-like locations. 497

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

This holiday travel season will look a lot different because of the pandemic. Some people can’t imagine booking a trip. Others are checking flights, pricing, or calling a travel agent.Kathy Facione of Rochester Hills loves to travel.She’s been exploring the globe in recent years – visiting Italy, Ireland, and Iceland – to name a few.Facione has not flown since February due to the pandemic, but she is planning a fall trip to Wyoming.“I’ll have a half-day in Grand Teton, all day in Yellowstone, I have a chuckwagon dinner scheduled one night, and a horseback sunset trip planned another night,” she said explaining her itinerary.I had to ask her, “Have you had anybody say, ‘You’re flying during a pandemic?! What?!’“Yeah, yeah. A few people think I’m crazy. They think it’s too early,” she replied with a smile.But Facione wears her mask consistently and follows health and safety guidelines. Now she’s ready to explore.BOOK NOW? OR LATER?But what do people need to know if they’re considering booking travel over the holidays this year with coronavirus still a concern around the world?I asked Jill Jones for some advice.Jones is a Travel Concierge with Cadillac Travel in Southfield, and she’s been keeping track of all the COVID-19 travel advisories and how the industry is responding.“You need to understand completely what you’re buying. Like, what is your ability to change this? What’s your ability to get it refunded? What is the window for that? So that, all, you need to understand all of that before you put your money down,” Jones said.Of all the airlines, Jones said she thought Delta has been doing the best job with cancellation policies, cleaning protocols, mask mandates, and social distancing.Delta just announced it is extending its policy of blocking middle seats and limiting the number of customers on every flight through January 6 of 2021 (Delta will make the middle seat available for parties of 3 or more traveling together).Jones said Delta, like other airlines, has also been fairly flexible during this health crisis.If you buy a ticket right now with Delta, Jones explained that you can change that without the airline’s normal 0 change fee or get a voucher that’s good for almost two years.But if you’re considering booking travel for the holidays this year, Jones advises you not to wait.“If you wait until November to decide to make your December reservations, you’re probably not going to get what you want, and you’ll pay a lot more than you need to. But people are stuck in [that mindset] – ‘Do I really want to do this?’” Jones explained.She said if people are hoping for some big “COVID fire sale” of sorts, that’s not going to happen because airlines – like Delta – are blocking 30-percent of their inventory, and eventually, prices will go up.BEACH VACATIONS?As for warm getaways this winter, Jones said places like Mexico, Aruba, Jamaica, and St. Lucia are open – for now – but some may require a negative COVID-19 test.Bottom line, Jill Jones said travelers need to understand what they’re buying -- including details about the cancellation or change policies.“So, I encourage all my clients to book in a format that they can either change it right up until the day before or they can get a full refund if they just decide not to go,” Jones explained.Jones said it’s also very important for people to monitor each tourist area’s coronavirus situation and entry requirements.“The airlines are not deciding the rules. It’s the governments of these countries that are deciding the rules. So, you can well get on a plane and not have what you need to get off that plane because it wasn’t up to the airline to tell you that,” said Jones.The U.S. Virgin Islands just closed to leisure travelers on Aug. 19 for at least one month to help contain the spread of the virus.Hawaii will not re-open to tourists until at least October first due to a surge in positive cases there.And when it does re-open, Hawaii may still require a 14-day quarantine – meaning tourists must stay at their hotel or rental lodgings for two weeks before venturing beyond those properties.As for Kathy Facione, she is already thinking about booking a getaway in December.“I’d like to take another trip around Christmas time just to get away and out of the cold -- maybe do something like a spa or something like that,” Facione saidSo, the Red Rocks of Sedona may be calling for Kathy despite the coronavirus.This story was first reported by Alicia Smith at WXYZ in Detroit, Michigan. 4507

TORONTO, Canada (KGTV) - Incredible dash cam video shows tires flying after a car hit a tow truck Saturday on a Toronto, Canada highway.The camera attached to Adil Kanan’s tow truck was recording the moments Kanan stepped out to help three people in a disabled pickup truck."They seemed to be all alert and fine," he told CTV Toronto.RELATED: Tow truck driver seriously injured in crash on SR-125Karan returned to his truck to alert police that his vehicle and a truck were blocking one lane of the freeway."As I was sitting there looking through my back window, that's when I observed the white Lexus approaching at a high rate of speed," he said.The white vehicle hit the pickup truck, sending debris flying.RELATED: Bear opens door, steals from car in Lake TahoeOne of the pickup truck’s passengers had been standing outside the truck and was thrown into the guardrail.Two people inside the truck were ejected, and the driver ended up face-down on the highway. All three were listed in stable condition.CTV News contributed to this report.  1056

There is a nationwide voluntary recall of almost 19,000 bottles of hand sanitizer over concerns the mixture contains methanol.The Food and Drug Administration announced Monday the company ITECH361 is recalling their All Clean Hand Sanitizer, Moisturizer and Disinfectant sold in one liter bottles. The 18,940 recalled bottles have UPC Code 628055370130.According to the FDA, substantial exposure to methanol (wood alcohol) can cause nausea, vomiting, headache, blurred vision, and more serious conditions including death. There are no reports at this time of anyone getting sick from the recalled sanitizer.This may sound familiar. Last month, the FDA warned people about sanitizer from the manufacturer Eskbiochem SA de CV in Mexico Because of possible methanol concerns.The ITECH361 product was distributed around the country to distributors and retailers. Retailers are encouraged to pull it from their shelves, those who purchased it are asked to stop using it and return the product for a refund.Consumers with questions regarding this recall can contact Corina Enriquez by phone number (888)405-4442 or e-mail at corina@itech361.com, Monday through Friday beginning July 6, 9:00a.m. to 5:00 p.m. (MDT). Consumers should contact their physician or healthcare provider if they have experienced any problems that may be related to using this product. 1361