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This Thanksgiving is shaping up to be like no other.With the U.S. experiencing a spike in COVID-19 cases, the Centers for Disease Control and Prevention (CDC) is advising Americans to celebrate turkey day with the people they live with, as opposed to traditional feasts with extended family and friends.With many people celebrating the holiday is small groups, it may be easier and more cost efficient to order takeout or ready-made meals this year.Not only could ordering in save you money and work, it may also serve as an opportunity to support the restaurant industry that has been hit so hard by the pandemic, especially small establishments. The business could help them make up for lost revenue. A survey released by National Restaurant Association in September found that 1 in 6 restaurants was closed either permanently or long-term, nearly 3 million workers were out of work, and the industry was on track to lose 0 billion in sales by the end of 2020.There are endless options for takeout for your Thanksgiving meal. You could celebrate with any cuisine, but if you want to stick to traditional foods, some national chains are offering turkey day dinners. Here are a few:Denny’s – The restaurant is offering a family-style “Turkey & Dressing Dinner Pack” that can be picked up until 6 p.m. on Wednesday, Nov. 25.Cracker Barrel – Like in years past, the chain is offering meals for gatherings of all sizes, including its “Thanksgiving Heat n’ Serve Family Dinner.”Boston Market – This chain may also be an option, as it serves up plated meals, family meals, whole pies and hot side dishes.Offers.com also compiled a list of more than 30 restaurant chains that are open on Thanksgiving.Regardless of where you order from, consider leaving a tip for the restaurant employees who are not only working on Thanksgiving, but also in the midst of a pandemic. 1876

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

They have become the Holy Grail of cleaning supplies this pandemic year: Lysol and Clorox wipes. Trying to find them is often an exercise in futility.Throw in Windex spray, Scrubbing Bubbles shower cleaner, and Formula 409, and they round out the list of popular disinfecting products that are nearly impossible to find in stores these days.Coleman Henderson, owner of a house cleaning company, said he often has to tell homeowners he can't come out that week because of disinfectant shortages."I have to postpone jobs because I can't get cleaning supplies." Henderson said.You can sometimes find these items for sale on Amazon (from third-party sellers) or eBay, but you may have to pay two to three times the retail price, if you can find them at all."People are really struggling right now, " said Grace Brombach, of the consumer watchdog group U.S. PIRG. "The last thing that they need to worry about is going online and finding the products that they really need to keep themselves safe at ridiculous prices."National brands remain in short supplyStan Beck, owner of a hardware store, said that even though national brands like Windex or Johnson are hard to find, off-brand products are often just as good."This is a basic product, like Windex, just a different brand," he said, pointing to a shelf of Brillo window cleaner in his store. Brillo? Yes, they make window cleaner, and he says it works as well as Windex.Some items, though, are in such short supply that even generic versions are hard to find.For instance, toilet paper is now plentiful, but paper towel supplies remain tight. Why? A CNN report says manufacturers worked overtime all summer to produce toilet paper, but did not boost paper towel production to the same extent.The result?Grocery stores now have enough toilet paper (though they are limiting sales again), but not enough Bounty or Scott paper towels.What you can doKaren Mallory is the manager of a Do-it Center. She has a shelf stocked with cleaning products that looks like a throwback to 2018.During our visit, she had Windex, Mr Clean, Spic n' Span, even a collection of N95 face masks, something that was impossible to find for five months.Mallory said many people don't realize that local hardware stores often have a much better selection than grocery or big box stores because of their group buying power, and the fact that fewer shoppers visit them for cleaning items.She said she can find almost anything, except those Holy Grail items: name-brand disinfecting wipes."We've tried ordering Lysol wipes," she said. "Absolutely. We're trying to keep up on what supplies we can. Some things are just not available."It's the same situation at grocery stores like Kroger.The spokeswoman for the nation's largest grocery chain, Kroger, Erin Rolfes said "our suppliers are continuing to work extra hours to keep up with the ongoing customer demand," but said shoppers buy out wipes and disinfectants the moment they are put on the shelves.So what can you do?Visit your grocery store midweek, first thing in the morning, when those wipes and other products are put out.Purchase store brands, or off brands, when you find them, especially when it comes to wipes and toilet cleaners.Visit your local hardware store, and get to know the manager. Some will hold products for you if you ask.Check Amazon frequently.But U.S. PIRG says resist the urge to pay double or triple the price on eBay, because that encourages sellers to charge even more.And report gouging to Amazon customer service. That way, you don't waste your money.___________________________Don't Waste Your Money" is a registered trademark of Scripps Media, Inc. ("Scripps").Like" John Matarese Money on FacebookFollow John on Instagram @johnmataresemoneyFollow John on Twitter (@JohnMatarese)For more consumer news and money saving advice, go to www.dontwasteyourmoney.com 3876

This image provided by Oakley shows sketches of the new face shield designed by Oakley. With NFL training camps set to start at the end of the month, the league believes it is closer to one answer when it comes to player safety in the midst of the coronavirus pandemic. Face shields for the players' helmets. (Oakley via AP) 333

They call it "The Game." But one of the fiercest rivalry college football games will have to wait a few more weeks due to the massive Camp Fire burning in Northern California. Due to the poor air quality in the Bay Area from the Camp Fire, Saturday's Stanford/California football game has been postponed until Dec. 1. The game will take place one day after the Pac 12 championship game, but both teams have already been eliminated from contention. As of Friday, the Camp Fire has killed at least 63, and hundreds are missing. The game, which was going to be held on California's Berkley campus, is just one of many college sporting events being postponed this weekend due to poor air quality. "We have been carefully tracking air quality in Berkeley and the Bay Area over the past week, relying on the best data and guidance available to us from medical and environmental experts," California's Athletic Director Knowlton said. "The forecasts we have received show a minimal chance of the improvement necessary to hold the game on Saturday. While we would have preferred to play the Big Game on its scheduled date, once we realized that air quality would likely not return to acceptable levels, we made the decision to postpone for the health and safety of our student-athletes, coaches, gameday staff, students, band and spirit groups, alumni and fans."Berkley is located roughly 150 miles from Paradise, which was the epicenter of the Camp Fire.  1481