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LA JOLLA, Calif., (KGTV)-- Several people at the University of California, San Diego [UCSD] were hospitalized early Saturday over alcohol poisoning, the school confirmed.A spokeswoman for UCSD told 10News that a total of seven people were taken to the hospital between 2:00 AM and 3:00 AM Saturday for severe alcohol poisoning. The emergency calls came from three locations on campus. One was from the undergraduate dormitories at Eleanor Roosevelt College, and two ambulances were dispatched to the Graduate Housing buildings. The school could not confirm if the patients were UCSD students or guests. While drinking is allowed on campus for students 21-and-over, the spokesperson did not say whether the hospitalized people were of age.10News spoke to students who recalled a lot of partying going on campus Friday night, where students appeared to be celebrating the end of finals and start of winter break."It was finals week, so it was very hectic," third-year student, Tyla Turner said. "It's like, you've been so much in the books for three to four weeks, you can finally go out. And it's like once you haven't been doing it that much, alcohol poisoning comes faster. It just hits you like that, you know?"These incidents come just a month after Dylan Hernandez, a freshman at neighboring San Diego State University died, after falling off a bunk bed while heavily intoxicated. Hernandez allegedly attended a fraternity party the evening before the fall. Since then, the state University has suspended all fraternity activities.To prevent tragedies like this from happening, last year, UCSD implemented a special policy for situations involving alcohol and drug intoxication. They call it the Medical Amnesty Program [MAP]. MAP states that if a student or organization finds another student in need of medical attention after drug or alcohol intoxication, they can call their advisor or campus police for help. As long as that student only uses the MAP policy once within two years, he or she will not have to go through a formal student conduct process. Second-year student Sydney Brown said she had no idea this policy existed. But she appreciates that this is in place to protect her peers. "If you're ever in that situation, you don't want to get your friend in trouble. You don't want to get in trouble. But if it's a life or death situation, you got to do what you have to do," Brown said. UCSD said everyone transported to the hospital was treated for non-life threatening conditions. 2507

LEFT: Alferd Packer in prison. Source: Colorado State Archives with credit to Littleton Museum and History Colorado. RIGHT: Leonel Ross O'Bryan, who wrote under the name Polly Pry for The Denver Post, believed Packer had been wrongly convicted. Courtesy of Denver Public Library. 287

Last year's seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, then, people had inadequate protection against the flu.This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today.This year's flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate professor at the University of Pennsylvania. Add to that, he said, "this could end up being a pretty bad flu season."Still, he said, "our best protection" against severe illness is getting vaccinated with the flu shot we have today.Finding answersEach year before flu season begins, a vaccine is made based on whichever virus strains are expected to circulate. The selected seed strains are distributed to vaccine manufacturers which then produce their formulations and make them available to health care professionals before the season begins.During the 2015-16 season, vaccine effectiveness was 47%, while for the previous 2014-15 season, effectiveness was just 19%, according to the CDC. While the overall effectiveness of last season's vaccine was 42%, it was only 34% effective against the H3N2 viruses that dominated the season.Vaccine effectiveness varies based on how well it matches the circulating virus strains. Sometimes, a vaccine corresponds to the predominant virus yet its effectiveness is still not what scientists would expect. Trying to understand which element of the vaccine failed is difficult.Hensley and his team began their investigation of last year's vaccine by looking at the seed strains that had been distributed to vaccine manufacturers. These seed strains had been propagated in chicken eggs, the common method used today."The sequences of these viruses are available and when we did an alignment to see what the sequence of these vaccines were compared to the viruses that were circulating, it became very obvious that there was this mutation," said Hensley.To see the effects of the mutation, the team next looked at how the immune systems of both animals and humans who'd been inoculated with an egg-based flu vaccine responded to the actual circulating viruses.The antibodies -- immune system proteins that fight invading pathogens -- elicited in both animals and humans failed to bind to and neutralize the flu viruses, Hensley and his colleagues found.While most vaccines in the United States are made in chicken eggs, a small fraction are produced in insects or mammalian cells, Hensley explained. (These are given to people with egg allergies.) He and his team compared immune responses in animals and humans who had received a cell-based vaccine -- in this case, Flublok made by Protein Sciences Corporation."And we found both animals and humans receiving that (cell-based) vaccine had superior antibody responses that could bind and neutralize these circulating H3N2 strains," said Hensley.Making a better vaccine"Most of the infrastructure to produce vaccines in the US is based on chicken eggs," said Hensley. There are good reasons for this, including the fact that egg-based propagation allows manufacturers to quickly produce large quantities of vaccine.While egg adaptations have always been a problem, beginning last year it had become a "huge problem," said Hensley. "As soon as you try to grow this virus in eggs, within a few hours, the virus will acquire this kind of mutation."This is not an easy problem to fix, he said. To produce vaccines in cells means "a very expensive process for companies to just change their overall manufacturing process," Hensley explained. "You can't really do that on the drop of a dime."Meanwhile, the same seed strains used last year are being used this year to make the current vaccine, said Hensley."This year may be especially difficult because, in addition to this egg adaptive mutation which was present last year, there's indication that the H3N2 viruses are actually evolving," said Hensley.Not only will the vaccine be a mismatch with the actual circulating viruses due to egg adaptation but the vaccine could also be a mismatch due to unexpected viral evolution.What kind of flu season is ahead?It's too early to speculate which viruses will become dominant in the United States over the course of the coming flu season, said Hensley, "but it's starting to look like it will be H3 viruses." H3 viruses are influenza A viruses."There are the A group of viruses and the B groups," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. "The A groups are the ones that usually are responsible for large epidemics ... whereas the B flu strains usually smolder along. They always cause illness -- it can be just as severe as the A strains -- but they don't produce large outbreaks."Though last year's vaccine was mostly ineffective in thwarting the flu, it still prevented nearly 30% of hospitalizations that might have resulted, according to CDC calculations. For older adults, that rate was even higher, at 37%. Plus, the vaccine reduced outpatient visits by 42% last season.The CDC advises everyone 6 months and older to get a flu shot, as only injectable flu vaccines are recommended. More than 130 million doses of flu vaccine have been distributed so far this year and flu activity is still low across the nation.It's still early days, but experts believe we may be facing a tough season, and not only because of vaccine concerns.The reason?Australia had a tough flu season this year, with a total of 215,280 laboratory-confirmed cases and 504 flu-associated deaths reported to its National Notifiable Diseases Surveillance System as of October 13, government data show. According to a surveillance system report, adults over the age of 80 and children between 5 and 9 years old have been most affected."In general, we get in our season what the Southern Hemisphere got in the season immediately preceding us," Dr. Anthony Fauci, director of the United States' National Institute of Allergy and Infectious Diseases, said in an interview last month.An "intelligent guess," therefore, is that the Northern Hemisphere, like the Southern Hemisphere, will likely battle more cases of the viral infection, he said, though "with influenza, it is never 100%.""If H3N2 viruses dominate the US flu season again this year, vaccine effectiveness will likely be moderate to low again," said Hensley.Still, he said, everyone should get their annual flu shot."The other components of the vaccine, like H1N1 and influenza B, will likely provide excellent protection," said Hensley. "The vaccine will also likely prevent severe disease and death caused by H3N2 viruses, even though this component of the vaccine is mismatched."  6969

Law enforcement authorities are searching for a man who's suspected of threatening to shoot President Donald Trump.Shawn Richard Christy, of McAdoo, Pennsylvania, was last seen in Cumberland, Maryland, Sunday night driving a stolen vehicle, according to the authorities.The US Marshals Service is offering ,000 for information leading to Christy's arrest. Christy has been wanted on a June 19 federal warrant, accused of posting threats on Facebook against the President and Northampton County District Attorney John Morganelli.According to officials, Christy posted, "Keep it up Morganelli, I promise I'll put a bullet in your head as soon as I put one in the head of President Donald J. Trump."Christy is a 27-year-old white man who stands at 5 feet 10 inches and weighs about 160 pounds, according to a flyer released by the FBI. He has short dark blond hair, a large tattoo on his right upper arm of a "pointed cross and barbed wire," and speaks with a distinct lisp.Kentucky State Police said that upon reviewing surveillance footage it appears on Aug. 9 Christy stole a green 2001 Jeep Grand Cherokee with a black hood from the residence of Timothy Gilliam. Gilliam is the brother of Dakota Meyer, a Medal of Honor recipient and former husband of Bristol Palin.Christy could be driving another stolen vehicle at this point, according to authorities.Christy is also wanted on Pennsylvania state warrants for "burglary, probation violation, and failure to appear for an aggravated assault case," according to the marshals, and threatened to use "full lethal force on any law enforcement officer that tries to detain me."The FBI, US Secret Service and US Marshals Service are seeking the public's assistance in locating Christy, who is armed and dangerous and should not be approached. Officials ask anyone with information regarding Christy's whereabouts call the US Marshals at 1-877-WANTED-2 (1-877-926-8332). 1926

Linda Brown, who as a little girl was at the center of the Brown v. Board of Education US Supreme Court case that ended segregation in schools, has died, a funeral home spokesman said.Brown died Sunday afternoon in Topeka, Kansas, Peaceful Rest Funeral Chapel spokesman Tyson Williams said. She was 75 years old.Brown was 9 years old when her father, Oliver Brown, tried to enroll her at Sumner Elementary School, then an all-white school in Topeka, Kansas.When the school blocked her enrollment her father sued the Topeka Board of Education. Four similar cases were combined with Brown's complaint and presented to the Supreme Court as Oliver L. Brown et al v. Board of Education of Topeka, Shawnee County, Kansas, et al.The court's landmark ruling in May 1954 -- that "separate educational facilities are inherently unequal" -- led to the desegregation of the US education system. Thurgood Marshall, the NAACP's special counsel and lead counsel for the plaintiffs, argued the case before the Supreme Court.Kansas Gov. Jeff Colyer acknowledged Brown's contribution to American history."Sixty-four years ago a young girl from Topeka brought a case that ended segregation in public schools in America. Linda Brown's life reminds us that sometimes the most unlikely people can have an incredible impact and that by serving our community we can truly change the world."Brown was a student at Monroe Elementary School in 1953 and took a bus to school each day."My father was like a lot of other black parents here in Topeka at that time. They were concerned not about the quality of education that their children were receiving, they were concerned about the amount -- or distance, that the child had to go to receive an education," Brown said in a 1985 interview for the documentary series "Eyes on the Prize: America's Civil Rights Years.""He felt that it was wrong for black people to have to accept second-class citizenship, and that meant being segregated in their schools, when in fact, there were schools right in their neighborhoods that they could attend, and they had to go clear across town to attend an all-black school. And this is one of the reasons that he became involved in this suit, because he felt that it was wrong for his child to have to go so far a distance to receive a quality education."Monroe and Sumner elementary schools became National Historic Landmarks on May 4, 1987, according to the National Park Service. President George H.W. Bush signed the Brown v. Board of Education National Historic Site Act of 1992 on October 26, 1992, which established Monroe as a national park. 2632