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As the world waits for deliveries of Pfizer’s coronavirus vaccine, the pharmaceutical company is having to adjust their target after hitting supply chain obstacles, according to the Wall Street Journal.“Scaling up the raw material supply chain took longer than expected,” a company spokeswoman told the WSJ.Pfizer and partner BioNTech SE had hoped to ship out 100 million doses of their vaccine by the end of the year, that has now reportedly been cut to estimates of about 50 million.Two doses are needed for each person to be vaccinated.Pfizer did not elaborate on where the raw material shortfalls happened. They did say some raw materials in early production earlier this year did not meet their standards and they had to fix the issue.After the WSJ’s report, Pfizer’s stock price dropped and the S&P 500 fell slightly.The United Kingdom has granted emergency use of the Pfizer vaccine, and is expected to start administering doses soon. The FDA in the U.S. is considering a similar authorization, which could come later in December.As part of Operation Warp Speed, the U.S. Government has purchased 100 million doses of Pfizer’s vaccine, with an option to buy more.Roughly 20 million of those doses were expected by the end of the year once the FDA granted emergency use authorization. No word on how Pfizer’s shipping delays could impact this number.Pfizer says their production lines in the U.S. and Europe are complete and they are “confident” they will supply the targeted number of doses in early 2021. 1524

At least three people died and 67 were injured after a tanker truck exploded on a highway in Bologna, Italy, a spokesman for Italian state police told CNN.Marco Granna, a spokesman for the local health agency in Bologna, told CNN that 55 people were taken to the hospital for treatment of first-, second- and third-degree burns.At least two of the injured are police officers, the Italian highway patrol told CNN.Footage of the incident showed an enormous fireball and plumes of thick, black smoke in the sky .The explosion ripped through the pavement, leaving huge holes in the road surface.According to police, the incident took place at Bologna Casalecchio and the junction with the A14 route from Bologna to Taranto.  734

As states prepare to assist in distributing potential coronavirus vaccines by November 1, Surgeon General Jerome Adams doubted a vaccine would be ready so soon.Speaking to ABC’s Good Morning America, Adams said a Nov. 1 vaccine was “possible, but not probable.”Last week, the federal government asked states to be prepared to begin assisting in distribution of COVID-19 vaccines to the public this fall.The memo signed by CDC head Robert Redfield told governors that the federal government has contracted with the McKesson Corporation to assist in distributing the vaccine to local and state health departments, medical facilities, doctor officers, and other vaccine providers.So why is the government getting states ready for a vaccine on November 1 even if it’s unlikely a vaccine will be approved by then?"It's not contradictory information," Adams told Good Morning America. "We've always said that we're hopeful for a vaccine by the end of this year or the beginning of next year.""We want to make sure states are available to distribute it," he added.While there is urgency for both public health and economic reasons for a vaccine, some experts have expressed concern over the speed of a vaccine and whether the expedited timeline is long enough to demonstrate efficacy. Dr. Anthony Fauci told NBC News on Wednesday that he believes a “safe and effective” vaccine could be ready by the end of the year."I believe that by the time we get to the end of this calendar year, that we will feel comfortable that we do have a safe and effective vaccine," he told NBC News.On Monday, a third vaccine candidate entered “Phase 3” trials in the US. AstraZeneca is testing its COVID-19 vaccine candidate for 30,000 participants. The AstraZeneca vaccine would come in two separate doses, according to the National Institutes of Health.Even though a vaccine could be ready by year’s end, trials will be expected to continue for over a year to monitor for possible side effects.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.”On Friday, President Donald Trump reiterated that a vaccine would be ready soon."We have tremendous, tremendous talent, some tremendous scientists, and they're right there, and I think you're going to hear some very good news,” Trump said. 2714

ATLANTA (AP) — A federal judge has sentenced a California man to serve 35 years in prison for traveling to Atlanta to have sex with a 9-year-old girl.The U.S. attorney's office in Atlanta said Tuesday that 40-year-old Craig Alan Castaneda of Imperial Beach must also register as a sex offender and serve 10 years supervised release after his prison term.Castaneda was convicted in December.RELATED: Alabama governor signs bill permitting chemical castration for sex offendersAn undercover FBI agent posted an ad on Craigslist in April 2015 posing as a mother seeking a "teacher" for her 9-year-old daughter. Prosecutors say Castaneda responded, describing his prior experience molesting children.Castaneda continued to communicate with the undercover agent for several weeks and made plans to travel to Atlanta. FBI agents arrested Castaneda when he arrived at the Atlanta airport on May 2, 2015. 904

BAKERSFIELD, Calif. — California Gov. Gavin Newsom has again denied parole for a member of the infamous "Mason family" who is serving time for a murder committed 50 years ago.Newsom blocked the release of 71-year-old Leslie Van Houten from prison Friday, despite a recommendation from the California parole board that she be freed.It's the fourth time in four years that Newsom has blocked Van Houten's release from prison. Newsom said in his Friday decision that she still poses a danger if released.Van Houten is serving a life sentence for helping Manson and others kill a Los Angeles couple in 1969. She was 19 years old at the time.Van Houten's attorney has said that she will appeal.This story was originally published by Tori Cooper on KERO in Bakersfield, California. 783