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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

SAN FRANCISCO, Nov. 4 (Xinhua) -- With its popular iPhone series, Apple seized more than half of the profits generated by the top eight mobile phone manufacturers during the third quarter, said a monthly market analysis released on Friday.Apple generated a remarkable 52 percent of handset industry operating profits for the top eight OEMs (original equipment manufacturers) in the third quarter, up five percent over the same period of 2010, said Canaccord Genuity technology analyst Michael Walkley.The number was down from 57 percent in the second quarter, due to a drop in iPhone sales as customers held out for the upcoming iPhone 4S.A proud Apple customer shows off the new iPhone 4S he purchased at an Apple store in Munich, Germany.Apple's major rival in the mobile industry is Samsung. The two companies together represented 81 percent of the handset industry' s operating profits last quarter.Other major mobile phone manufacturers are Nokia, Motorola, Sony Ericsson, HTC, Research In Motion and LG.Calling it "an epic reversal of fortunes," Walkley noted that in 2007, Nokia had 67 percent of operating profits while Apple had just 4 percent. Compared with Apple's 52 percent of industry profits in the third quarter of 2011, Nokia has been relegated to its rival's former position with just 4 percent of operating profits.The analyst said he has conducted "channel checks" that show strong demand not only for the new iPhone 4S but also for the previous models of iPhone 4 and iPhone 3GS. He told technology news website AllthingsD that Apple is believed to be able to gain further value share in the December quarter and capture over 60 percent of industry profits.In a Bloomberg report on Friday, several technology analysts said the two-year-old iPhone 3GS, whose price has been slashed to zero if it is purchased with a contract, will become one of Apple' s big weapons in the coming holiday season against smartphones running Google's Android system.

BEIJING, Nov. 6 (Xinhua) -- Employment quality in China is relatively low, which is a major reason affecting the quality of economic growth, says a latest report on the labor market.The report, released Saturday by the Labor Market Research Center of the Beijing Normal University focusing on the quality of employment in China, says Beijing, Shanghai and Tianjin were the top three cities in terms of employment quality, adding the overall employment quality in China is still low."Poor employment quality in China is a major reason for the poor quality of economic growth," said Lai Desheng, a professor with the Beijing Normal University.

YICHANG, Oct. 30 (Xinhua) -- China's Three Gorges Dam on Sunday reached its designed highest mark, the second time for the world's largest water control and hydropower project to run at full capacity.The water level hit 175 meters at 5 p.m. after storing water for nearly two months from the water level of 152 meters, said an official with the China Three Gorges Project Corporation (CTGPC), the developer of the project.A dozen hydropower turbo-generator units started operation on Sunday, generating power capacity of 8.2 million kw, said the official.The dam in central China's Hubei Province completed its first full-capacity test last October.Operating at full capacity should give full play to the dam's functions of generating hydroelectric power, delivering water to the lower reaches to alleviate spring droughts, and containing water from summer flooding, as required by the State Flood Control and Drought Relief Headquarters.The Three Gorges Project was launched in 1993 with a budget equivalent to 22.5 billion U.S. dollars.So far, monitoring shows the dam is operating smoothly.

来源：资阳报