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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) – At least 10 people were arrested during demonstrations in downtown San Diego Wednesday night that were sparked by the grand jury decision in the Breonna Taylor case.ABC 10News learned there were initially two separate protests planned in the downtown area. Eventually, the two groups joined together.Protesters marched through downtown chanting and holding signs demanding justice for Taylor. The demonstration made its way to San Diego Police Department headquarters on Broadway.Shortly after 10 p.m., SDPD tweeted that there were acts of violence and vandalism and declared the protest outside headquarters “an unlawful assembly.”According to the tweet, the crowd was ordered to disperse or face arrest. In response to acts of violence & vandalism, the protest in front of the SDPD Headquarters building (1401 Broadway) has now been declared an unlawful assembly.Demonstrators are ordered to immediately disperse. If you do not do so you may be arrested. pic.twitter.com/coUlOTVZ6p— San Diego Police Department (@SanDiegoPD) September 24, 2020 ABC 10News confirmed with police that at least 10 people were taken into custody during the protest, but officials did not disclose what charges the arrestees face.Taylor, a 26-year-old emergency medical worker, was shot and killed by Louisville police officers during a botched drug raid on her home in March. The warrant used to search her home was connected to a suspect who did not live there, and no drugs were found inside.A grand jury in Louisville on Wednesday decided that no officers will face charges for Taylor's death.Prosecutors argued the two officers who fired at Taylor were justified in using force to protect themselves after they were shot at by Taylor's boyfriend.The officer who fired the fatal shot and another officer who fired his weapon at Taylor face no charges, but former Louisville Metro Police Department Detective Brett Hankison was indicted with three counts of wanton endangerment for firing shots that went through Taylor's apartment and into an adjoining unit.City News Service contributed to this report 2118

SAN DIEGO (KGTV) – Close to 100 people packed the Sherman Heights community center Friday night.Just about all of them were there to tell city officials to back off their plan to set up a homeless storage facility at Commercial and 20th Streets.The city says the plan is not finalized, but they are in negotiations with leasing the building. “We have a playground is about 15 feet from this building,” said Noel Bishop, the principal at Our Lady’s School. “The reality is it’s just an open invitation for people to come back to this community and start living on the streets again… having people in our neighborhood that might be drug users, not mentally stable.”Jonathan Herrera, senior advisor for homelessness for the city of San Diego, says the site is expected to similar to the one on 16th street. It will be a place for the homeless to store their belongings while they visit clinics, classes or go to job interviews.The city is promising to be a good neighbor, stressing the site will have security 24/7.  There will be loitering, drugs or alcohol allowed, and they will have regular waste pick-ups within a block radius.“We are currently looking at other facilities in beach communities, uptown, mid-city and southeastern San Diego to see if we can provide additional services in those areas as well,” Herrera said. He said there were a lot of concerns raised that they are taking into consideration, but the city plans to move forward in the process and bring the plan to the San Diego Housing Commission on March 9th.“The mayor highlighted that the time to develop universal consensus is over and that effort to develop consensus has caused us action, and that’s no longer tolerable,” Herrera added. 1733

SAN DIEGO (KGTV) — Chicano history will be celebrated in San Diego this week at one of the city's most historic parks.On April 20, the Logan Heights community will celebrate the 49th annual Chicano Park Day at the famed park underneath the Coronado Bridge. The free festival brings together community members annually for art, education, entertainment, and honoring Chicano culture and the park.This year theme will be "Danzantes, Protectors of Our Traditions and Chicano Park, 500 Years of Anti-Colonial Struggle."Performances are scheduled by a lineup of traditional and cultural dance groups and one of the largest Aztec Indigenous dance performances by Danza Azteca Calpulli Mexihca. In addition to dancing, kids art workshops, speakers, and more than 325 classic lowrider cars and bikes will be on display. Attendees can also visit various arts and crafts, and informational booths throughout the colorful park.And, of course, there's the food, which will be sprinkled throughout the park at various booths.The event comes a couple days before the official establishment of Chicano Park on April 22, 1970, by activists. The site was placed on the National Register of Historic Places in 2013 and became a National Historic Landmark in 2016.The park is known for an array of colorful murals lining the Coronado Bay Bridge's legs that make up the Chicano Park Monumental Murals. Artists illustrate Chicano history and culture through murals and sculptures throughout the park. 1487

SAN DIEGO (KGTV) - Behind every mammogram Dr. Lisa Watanabe looks at is a woman waiting, and hoping, for good news. Dr. Watanbe is a radiologist, and the Chief Medical Officer for CureMetrix, an artificial intelligence (AI) technology company focused on early breast cancer detection.Their FDA-cleared software is able to learn, using millions of mammograms, to identify, mark, and score anomalies. "Cancers that were missed by a radiologist were detected by the machine, some of them weren't even small, sometimes they were just obscured by dense tissue," said Dr. Watanabe.She says the technology has found breast cancer up to five years earlier than it was found by the human radiologist. "It may detect features on mammograms the human eye can't detect," said Watanabe.The technology is already being used by doctors around the world and is also available to anyone with internet access.Women can pay 9 to get their own CureMetrix second opinion by uploading their mammogram to the online portal DocPanel.Dr. Watanabe says the software is not meant to replace humans but rather help them do their job better.San Diego resident Amanda Caniglia says the technology gave her peace of mind. "As a woman and going for my first mammogram and knowing the family history, there is a lot of anxiety going into it, you don't know what to expect," said Caniglia.While Caniglia's initial mammogram results came back normal, she wanted a second opinion because of her family history of cysts, tumors, and cancer. When the CureMetrix results also came back as normal, it was a huge relief. "it really lowered my anxiety and gave me peace of mind because I was able to know I'm good to go, I'm cancer-free."The technology is lowering the number of false positives and catching cancer earlier, giving more women the chance to find a cure in time. 1846