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CAMBRIDGE, Mass. – The U.S. government will pay Moderna Inc. up to .525 billion to secure 100 million doses of the company’s COVID-19 vaccine candidate.The U.S. Department of Health and Human Services (HHS) and Department of Defense (DoD) made the announcement Tuesday.HHS says Moderna will manufacture the vaccine doses while clinical trials are still underway to expedite the traditional development timeline and get vaccines to the public as soon as possible.The Trump administration hopes to deliver the vaccines by the end of the year, so long as the U.S. Food and Drug Administration (FDA) authorizes their use.“In creating a vaccine portfolio for Operation Warp Speed, the Trump Administration is increasing the likelihood that the United States will have at least one safe, effective vaccine by 2021,” said HHS Secretary Alex Azar. “Today’s investment represents the next step in supporting this vaccine candidate all the way from early development by Moderna and the National Institutes of Health, through clinical trials, and now large-scale manufacturing, with the potential to bring hundreds of millions of safe and effective doses to the American people.”HHS says the vaccine doses will be delivered to government-designated locations across the country and the U.S. could acquire up to an additional 400 million doses of the vaccine.If viable, the vaccines would be available to the American people at no cost, according to HHS. Healthcare professionals could charge for the cost of administering the vaccine, though.The vaccine, called mRNA-1273, has been co-developed by Moderna and scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The third phase of the vaccine trial, which began July 27, is the first government-funded Phase 3 clinical trial for a COVID-19 vaccine in the nation, according to HHS.“We appreciate the confidence of the U.S. government in our mRNA vaccine platform and the continued support,” said Stéphane Bancel, Moderna’s Chief Executive Officer. “We are advancing the clinical development of mRNA-1273 with the ongoing Phase 3 study being conducted in collaboration with NIAID and BARDA. In parallel, we are scaling up our manufacturing capability with our strategic partners, Lonza, Catalent and Rovi, to address this global health emergency with a safe and effective vaccine.” 2402

CARLSBAD, Calif. (KGTV) - LEGOLAND California Resort is inviting members of the military to visit the theme park for free in August.The resort opened the new LEGO City: Deep Sea adventure submarine ride this summer. It features real sharks, rays and fish before a backdrop of LEGO models.Active U.S. military personnel must show their military ID at any resort ticket booth or window for a same day Resort Hopper ticket during the month of August.RELATED: Exploring San DiegoThe ticket provides admission to LEGOLAND? Park, LEGOLAND? Water Park and SEA LIFE aquarium. Members of the military may visit the park as many times as they like in August.Friends and family tickets are available at discounted rates at base ticket offices, online at LEGOLAND.COM/military, and at a 10% discount at resort ticket booths.RELATED: LEGOLAND?California among TripAdvisor's top theme parks 894

By JOYCE M. ROSENBERG and KEN SWEET AP Business WritersNEW YORK (AP) — Americans are likely to see more "for rent" signs in the coming months. That's because many businesses devastated by the coronavirus pandemic are expected to abandon offices and storefronts. The changes are happening because more employees are working from home, and more people are shopping online. The result could bring an end to the long boom in the nation's commercial real estate market. Hotels, restaurants and stores that closed in March have seen only a partial return of customers. Many of them may fail. Commercial landlords have reported an increase in missed rent payments. They expect vacancies to rise through the end of the year. 724

CHICAGO -- Right now, nine COVID-19 vaccines are in or near a large-scale human trial phase. But enrollment of minorities in the trials remains a challenge. This is despite a disproportionate number of African-Americans impacted by the coronavirus.Earlier this month, ads from the National Institutes of Health began airing asking Black people and Latinos to volunteer for the coronavirus vaccine trials.“Operation Warp Speed” may be moving quickly, but pharmaceutical companies are having a difficult time getting Black and brown participants.“What we really bring to the table is moral persuasion and encouraging our population to participate in safe and ethical clinical trials,” said Reverend Anthony Evans, the president of the National Black Church Initiative. Over the past 15 years, they’ve worked with the pharmaceutical industry to boost Black representation in more than a dozen previous clinical trials.“I think that we can be a major help to both the government and the pharmaceutical industry if they use us,” said Evans.The Black community has been hesitant to take part in medical research and clinical trials because of a history of past abuse.Most infamously, the 40-year Tuskegee Syphilis Experiment that used Black men to study what happened when the disease went untreated.“They were just basically experimented on without their knowing about it or their understanding what was happening. And a lot of people had very bad outcomes because of this,” said Dr. Emily Landon, an infectious disease specialist at University of Chicago Medicine.A recent Pew study found that Black Americans are still more skeptical of experimental treatments and a potential COVID-19 vaccine than Hispanic and white adults.Add to that, most of the current trials are recruiting mainly online, something experts say often results in mostly white people enrolling.“We will know more and be able to do a better job in caring for our friends and patients of color if we have more participation in these trials,” said Landon.Moderna had to delay trials because of a lack of diversity. As of earlier this week, 13% of Moderna’s enrollment volunteers were Black and 51% white. At the same time, only 8% of Pfizers volunteers are Black and 75% white.“They are going to have a significant shortfall of data when it comes down to African Americans and other groups, especially Latinos, and simply because they have not made the efforts,” said Evans.In the end, the vaccine must be at least 50% effective to receive FDA approval. Without a diverse group of volunteers, experts say it could be difficult to know just how safe and effective the vaccine actually is across races. 2672

CAMP PENDLETON, Calif. (CNS) -- Three wildfires continued burning across open terrain on the grounds of Camp Pendleton Wednesday, sending plumes of smoke over northern San Diego County but posing no threats to military or civilian structures.The flames began spreading through training areas toward the center of the Marine Corps base on Monday.As of Wednesday afternoon, base officials said one of the fires, dubbed the Wood Fire, has burned 7,000 acres and is 20 percent contained.A second fire, called the India Fire, has burned 1,100 acres and is 20 percent contained.A third fire named the Range Fire is burning in the Range 706 Yankee impact area and has charred 500 acres, according to base officials.Base officials said the fires are expected to produce smoke through the remainder of the day, and the fires are not posing a threat on or off the base.Military firefighters have been aided by Cal Fire ground and airborne crews in their effort to corral the blazes.Officials have disclosed no cause for the fires. It is not uncommon for munitions training to set brushy native vegetation ablaze at the 125,000-acre USMC base north of Oceanside. 1159

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