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SAN DIEGO (KGTV) — The circus comes to San Diego this weekend in a pair of fun events and, of course, the craft beer and spirits are flowing elsewhere.Circus Vargas brings the big top back to Mission Valley for a weekend of acrobatic and astounding acts by circus performers. Chula Vista also hosts Circus in the Park with shows and workshops with performers with Fern Street Circus.Carlsbad's Flower Fields open for business this weekend, with their 50-acre display of beautiful Ranunculus flowers in bloom for the spring.The Mission Valley Craft Beer and Food Festival serves up delicious craft beers and food with a bacon twist from independent brewers and local chefs. The Mariachi Fest also pairs dazzling mariachi and folklórico performances with taco and tequila tastings in Escondido.THURSDAYCircus VargasWhere: Westfield Mission Valley; Cost: - Take your kids to the Big Top for a weekend packed with circus action as Circus Vargas hits Westfield Mission Valley. Acrobats, daredevils, and flying trapeze artists will perform to audiences' delight, recreating circus feats from the past for a new audience.Museum MonthWhere: Various locations; Cost: Prices vary(Thursday - Saturday) Throughout the month of February, San Diegans and visitors can pick up a special, free pass to save 50 percent at more than 40 museums throughout the city. Museums like the Fleet Science Center, Maritime Museum, San Diego Air & Space Museum, Natural History Museum, and many more are participating in the special month.FRIDAYKuumbaFestWhere: San Diego Repertory Theatre; Cost: - 5KuumbaFest brings three days of African-American culture, expression, and heritage to San Diego with traditional art, performances, educational workshops, a marketplace and health fair, Gospel concert, guest speakers, and more in celebration of our African-American community. Illumination: 21st Century Interactions with Art + Science + TechnologyWhere: San Diego Art Institute; Cost: FreeThe San Diego Art Institute hosts a free exhibit featuring an interactive show created by 26 artists. Guests will experience art through light, sound, metal, textiles, soundscapes, and more. The exhibits will walk visitors through issues like climate change, global health, and sustainability through art.SATURDAYMission Valley Craft Beer & Food FestivalWhere: SDCCU Stadium; Cost: - Enjoy sips and eats from dozens of independent San Diego breweries and eateries at SDCCU Stadium. Entry gets ticket holders unlimited tasters of craft beer and spirits and eats from each food vendor. The event will join forces with Bacon Fest to deliver some mouthwatering combinations of bacon and bites to guests.Circus in the ParkWhere: Chula Vista Bayfront Park; Cost: FreeChula Vista hosts a free day of activities for families during Circus in the Park. Exciting acts from Fern Street Circus, like jugglers and acrobats, will entertain crowds. Circus experts will also hold interactive workshops around hooping and tightwire activities, and face painting and photos booths.Leap Day CelebrationWhere: The Old Globe Theater; Cost: FreeHead over to Balboa Park where performers will stage a dance-of at the Old Globe Theater plaza. The fun starts at 11 a.m. with dance troupe performances and continues with workshops and dance competitions.SUNDAYMariachi FestivalWhere: California Center for the Arts, Escondido; Cost: - 0Take in the traditional sounds and sights of the Grammy-winning Mariachi Divas de Cindy Shea and folklórico dancers from Tierra Caliente Academy. Attendees can also spend the day at the festival's Tacos & Tequila reception, where they can sample spirits and participate in a silent auction.TinyFest CaliforniaWhere: Del Mar Fairgrounds; Cost: - Del Mar Fairgrounds will host several ideas in the world of "tiny homes" during TinyFest, featuring the latest in tiny living options, expert speakers, workshops for guests, and festival music and foods.Carlsbad Flower FieldsWhere: The Flower Fields; Cost: - Sunday is opening day for the Carlsbad Flower Fields this season! Peruse through 50 acres of beautiful variations of Ranunculus flowers, an artists garden, floral displays, and more. 4213

SAN DIEGO (KGTV) - The mother of a Southern California girl diagnosed with rat-bite fever is sharing her story at a San Diego hospital Friday to educate other parents about the danger. Rat-bite fever is a potentially deadly infection spread through contact with domestic rats. 8-year-old Cali from Menifee contracted the disease when the rat’s saliva came into contact with an open wound, according to Rady Children’s Hospital officials. Cali has eczema on her fingers which may have contributed to the situation, a doctor said.Rat-bite fever is a bacterial disease which can cause a rash, fever, and body aches.The illness started Friday night, said Cali's mother Sabrina. By Sunday, Cali had a fever of 104.6 degrees. She lost the ability to use her hands and arms and had a whole-body rash."Really, really scary. Really hard to watch," said Sabrina.Cali's family bought two rats, Shell and Onyx, from a feed store about two years ago with no warning about the potential of rat-bite fever.Doctors recommended the family get rid of their rats."We didn't want to do it," said Sabrina. “It’s not a fun thing to tell your kid you’ve got to get rid of your best friend."Cali's mother had a recommendation for other parents."Just know that this can happen," she said. "Wash your hands."Watch the news conference at Rady Children's Hospital: 1344

SAN DIEGO (KGTV) - The father accused of causing a condo fire in Rancho Bernardo that killed his two children appeared in court Tuesday afternoon for a preliminary hearing.Henry Lopez is accused of passing out drunk with a lit cigarette, setting his condo on fire last October.His children, 10-year-old Cristos and 7-year-old Isabella, were in the home at the time and suffered smoke inhalation. Both children died as a result of their injuries.Lopez was also burned in the fire and hospitalized for some time.One witness told the court Tuesday he heard a female screaming at the scene, but the screaming stopped.RELATED: Father charged after children killed in fireHenry Lopez' ex-wife Nikia Lopez testified the two were in the midst of a divorce. They shared joint custody of their children.  Lopez told the judge her former husband was an abusive alcoholic.She claims she had warned him previously not to smoke in the house around the children."He drank a lot. My goal was to keep it from the kids.  I would wake up in the middle of the night and throw away the bottles in the trash. I would pull him upstairs before the kids woke in the morning... sometimes I would have to clean up his throw up."  He’s not in custody because his defense attorney says he needs to be out to receive medical treatment for the burns he sustained during the fire.Prosecutors believe the fire started in his bed and ultimately spread to the rest of the home.  Investigators found discarded smoking materials and alcohol near the start of the fire.If there’s enough evidence against Lopez and the case goes to trial, he faces up to 14 years in prison for several felony counts including involuntary manslaughter and child endangerment.Lopez is not charged with intentionally starting the fire. 1809

SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) - The County of San Diego is changing who can get a COVID-19 test at county sites.Officials said Monday that going forward, the county is focusing coronavirus testing efforts for priority groups, including those with symptoms."For new appointments being made, those will be focused on individuals who are symptomatic or individuals who are asymptomatic that fit into some of our priority groups like healthcare workers, first responders, those with chronic or underlying health conditions and those living in long-term care facilities," said County of San Diego Supervisor Nathan Fletcher.Fletcher said the county has more sick people and more positive cases, which means there's a greater demand on the testing system.He explained that challenge is being compounded by a global supply chain shortage with testing supplies and components."By taking this approach to reprioritize our focus on symptomatic folks and asymptomatic folks who are in the settings I just described we might see a reduction in the number of tests being done, but we do hope to see an increase in the speed in which we're able to turn around those tests," Fletcher said.Testing supply issues are not just a local problem. On Monday, California Gov. Gavin Newsom was asked about supply issues and test result turnaround times."It's unacceptable in this nation and in this state that we are not in a position to be doing even larger scale testing that all of us have been very, very aggressively promoting and trying to manifest," Newsom said, adding that the state is also starting to see delays in testing results.Harvard researchers have said the timing of testing results is crucial."If it takes over a week for the result to come back, mathematically it becomes challenging for testing and contract tracing alone to be adequate," Dr. Thomas Tsai, assistant professor in the Department of Health Policy and Management at Harvard T.H. Chan School of Public Health and a surgeon at Brigham and Women's Hospital.Harvard researchers found most states still fall short when it comes to testing.Here in California, the state Department of Public Health reports more than 5 million tests have been conducted across the state.On a call with reporters last week, Tsai said California is testing a very high number of people, but relative to its population, it's falling short of its target for suppressing COVID-19."What happened in California is, as the cases have increased, the testing has increased in proportion but hasn't increased to a level where testing has outpaced the growth of cases and the ability to contact trace has actually gotten ahead of the infection and gotten control of it," he said.On Monday, San Diego County officials announced a partnership with local company Helix to provide up to 2,000 tests a day.County officials say they've received 7,500 tests and those are already being used at two sites.Another 10,000 will be sent tomorrow and they expect within a week that every site will be using them.That will ease some of the burden, but won’t cure the overall problem. 3089

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