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As questions arise over when a coronavirus vaccine should be granted FDA approval, the leaders of several major pharmaceutical companies announced they have signed a pledge not to rush the development of a vaccine.The companies, AstraZeneca, BioNTech, GlaxoSmithKline, Johnson, Merck, Moderna, Novavax, Pfizer and Sanofi, released a joint statement on Tuesday confirming the pledge.The pledge includes the following points:Always make the safety and well-being of vaccinated individuals our top priority.Continue to adhere to high scientific and ethical standards regarding the conduct of clinical trials and the rigor of manufacturing processes.Only submit for approval or emergency use authorization after demonstrating safety and efficacy through a Phase 3 clinical study that is designed and conducted to meet requirements of expert regulatory authorities such as FDA.Work to ensure a sufficient supply and range of vaccine options, including those suitable for global access.There has been pressure on both the FDA and manufactures to develop and approve a vaccine for the coronavirus. There have been more than 190,000 coronavirus-related deaths in the US since March, and the economic impact of the virus has cost millions of jobs.While most developed countries have not had the same public health pain as the US, the economic impact of the virus has been felt worldwide. The International Monetary Fund estimates a nearly 5% loss in global GDP in 2020.In Russia, the country claimed to begin distributing a coronavirus vaccine despite US-based vaccine candidates likely being months away from being able to demonstrate efficacy.The pressure domestically has also ratcheted up as President Donald Trump has suggested a vaccine could be ready by this fall’s presidential election."We're going to have a vaccine very soon... maybe even before a very special date, you know what date I'm talking about,” Trump said on Monday.In late August, the CDC told states to begin to prepare distributing a vaccine by Nov. 1. But Surgeon General Jerome Adams said that just because states will be ready to help distribute a vaccine on Nov. 1 does not mean a vaccine will be ready by then."We've always said that we're hopeful for a vaccine by the end of this year or the beginning of next year,” Adams told Good Morning America."We want to make sure states are available to distribute it," he added.The companies signing on the pledge said that the FDA has strict protocols for vaccine candidates. A typical vaccine trial takes one to three years, but the companies believe only a safe and effective vaccine will be granted approval.“FDA has established clear guidance for the development of COVID-19 vaccines and clear criteria for their potential authorization or approval in the US,” the companies wrote in the pledge. “FDA’s guidance and criteria are based on the scientific and medical principles necessary to clearly demonstrate the safety and efficacy of potential COVID-19 vaccines. More specifically, the agency requires that scientific evidence for regulatory approval must come from large, high quality clinical trials that are randomized and observer-blinded, with an expectation of appropriately designed studies with significant numbers of participants across diverse populations.” 3296

As schools start re-opening around the country, daycare and early childhood education centers are opening too.A question on the mind of parents is, "Should you send your toddler or preschooler back?"Like every other working mom, Danielle Green admits it's challenging. She basically has two jobs. Her career as a scientist, and her around-the-clock job of mom to 2-year-old Corey and 6-month-old Dylan keeps her busy.“Having children is a full-time job in itself so it turns more into a full-time job watching kids during the day and then doing the work during nap and evening,” Green said.It’s is not only exhausting, but she says, it's 100 percent, not realistic.“It adds a lot of stress for parents,” Green said. “For me, it added a lot of stress because we want to dedicate as much time as we can to our kids and so I took the path to dedicating everything to my kids and doing the work while the kids were sleeping.”So, when her daycare opened back up, Green and her husband talked and decided it was time.“There’s uncertainty in sending a child to daycare during a pandemic, but if we’re being realistic, eventually our kids are going to have to go back to school, so the question becomes at what point do we re-enroll them,” Green said.It's a topic that parents all around the country are discussing, because we all know it’s hard to do both. Parenting expert Gigi Schweikert said give up the dream of doing it all because no one can.“What I know as a working parent of four is that you can’t give your work 100% and you can’t give your children 100% so having your children in childcare gives them the opportunity to have the education socialization and guidance they need while you as a working parent can have that individualized concentrated time to give work your full attention,”Schweikert said.But to send your children back during a pandemic isn't easy. You have to do quite a bit of homework, make sure no one is allowed in the center aside from your child and staff members, and review all the protective measures for your county and state.Things like temperature checks, masks and face shields are being required at some daycares. Experts suggest inquiring about ventilation and cleanliness. And get parent referrals. A lot of them.“What really is important is trust. You’re going to need to check off all the boxes of making sure people are cleaning, making sure air is really good. Instinctually once you make that checklist, you have to say as a parent, 'Do I trust these people with my most important thing which is my child,'” Schweikert said.There are some things that might be missing because of COVID-19, like parent and teacher visits. Some facilities like Lightbridge Academy are now reliant on electronics and in-center cameras.Green said she's confident in her decision. Her boys are happy and healthy every day, and she feels confident that she's successfully managing her career.“It makes me feel good to know that the daycare is actually practicing the appropriate safety precautions and wearing the appropriate protective equipment, take temperatures it is an added measure,” Green said. 3130

AUSTIN, Texas — For Brett Hagler, the co-founder of non-profit New Story, building homes for people without adequate shelter is nothing new."We get a large piece of land and work with families that have been living in shacks or tents without shelter and design a totally new community with the families.”Approximately one billion of the world’s population is without proper shelter.To make a dent in that he says, they have to think outside the mold.“We believe traditional ways cannot get us there.”So for New Story’s next endeavor—adding more communities to the land they’ve already acquired in El Salvador—they teamed up with a brand new startup.That’s where Evan Loomis comes in. He’s the co-founder of Austin, Texas-based Icon, a company focused on new technologies for building homes.Their first big debut came at this year’s South by Southwest festival in their hometown.“This is a gigantic robot,” Loomis says, gesturing toward a large steel frame on wheels. “[It] really does some amazing things. Down to the millimeter it knows exactly where to place building materials.”In this case that material is a proprietary mixture of concrete, that pours out of a nozzle on the underside of the metalwork. And the machine moves along a computerized map to create a house.“This is basically the first permitted 3D printed house in the United States,” he said.“We have to invest in [research and design],” Hagler said. “[We asked ourselves] ‘how do we get a breakthrough in cost, speed, and quality?’ And that’s how we landed upon 3D-home printing. The excitement in the air is palpable as they walk us through and around this modest home built up of about 100 one-inch thick concrete layers.“It’s stronger than regular cinder block,” Hagler said. It also comes at a fraction of the cost of a regular house. This model had a price tag of about ,000 but they hope to get the price down to ,000.“We can build in a fraction of the time [compared to traditional construction methods], and it can have a higher quality, strength, and sustainability for the environment."It was 'printed' in just 48 hours. Eventually, they say it will be done in just a half day. It’s a small but open floor plan — with no physical doors — and rooms are separated by partial walls made up of the printed concrete.They say they’ll easily be able to customize different designs.The prototype home can fit a family of four or five.“If you’re coming from a tent or shack and you move into this,” Hagler said, “it’s a significant life-changing difference.”One of the things they’re most excited about with their upcoming 3D-homes project in El Salvador is the fact that they’re introducing groundbreaking technology to the people who usually see tech advances last.“We are actually bringing them the future -- which is robotic construction of housing — first,” Hagler said. “And they’re really excited about that.”They say they plan to begin construction in El Salvador before the end of the year with the hopes of finishing their first community of homes by early 2019. There could one day be plans for 3D printed homes in some of the poorest areas of the United States as well, Loomis said, but he has his eye set on possibly expanding to terrain that’s literally out of this world.“It could be a really great solution for making space habitation a lot more achievable,” Loomis said. “We hit a nerve with this technology, and we are going to hit the gas hard and try to take it to everybody now.” 3528

AUSTIN, Texas — A Texas man is making a statement by writing the names of 1,400 Black Americans who have died at the hands of police in the United States on his car.20-year-old Jeremiah Hindberg says he used a database to research Black Americans who have died at the hands of police in the U.S. and came up with 1,400 names.He wrote each one on his vehicle with a silver sharpie.Hindberg says he is using his car in hopes to start a conversation on what the Black Lives Matter movement means to him."A lot of sadness. I cried in my garage for hours," Hindberg said.It took several days to write the names, with George Floyd and Breonna Taylor on the hood."This is my representation of BLM," Hindberg said. "Some group of people that's being treated unfairly, and that should be fixed."Hindberg says the violence he and his father witnessed during the protests in Austin back in late May moved him more than anything he's ever experienced.The two served as medics and helped bring aid to injured protesters.He says many protesters were hurt by "less lethal" rounds fired by police, including his father who was shot in the arm and is still recovering from nerve damage today."It changed who my dad was fundamentally as a person," Hindberg saidAs a food delivery driver, Hindberg says reaction to the car ranges from being cursed out in grocery store parking lots to more warm moments of gratitude."She just looked at me in the eye, and said thank you so much she started to tear up and cry," Hindberg said, describing moments that remind him why he did this to his car. "Somebody knows that they're cared for. They're not just another number, they're not just another person."This story was originally published by KXXV in Waco, Texas. 1743

At least three people died and 67 were injured after a tanker truck exploded on a highway in Bologna, Italy, a spokesman for Italian state police told CNN.Marco Granna, a spokesman for the local health agency in Bologna, told CNN that 55 people were taken to the hospital for treatment of first-, second- and third-degree burns.At least two of the injured are police officers, the Italian highway patrol told CNN.Footage of the incident showed an enormous fireball and plumes of thick, black smoke in the sky .The explosion ripped through the pavement, leaving huge holes in the road surface.According to police, the incident took place at Bologna Casalecchio and the junction with the A14 route from Bologna to Taranto.  734