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WASHINGTON — U.S. health officials have started two new studies to test various blood thinners to try to prevent strokes, heart attacks, blood clots and other complications in COVID-19 patients.Doctors increasingly are finding blood clots throughout the bodies of many people who died from COVID-19 along with signs of damage they do to kidneys, lungs, blood vessels, the heart and other organs.National Heart, Lung and Blood Institute Director Gary Gibbons says that hospitals have been giving seriously ill patients anti-clotting drugs to try to prevent this, but “quite frankly, we didn’t know how best to treat it” in terms of which drugs or doses to use and at what stage of illness.The National Institutes of Health will coordinate a study in hospitalized patients comparing low and regular doses of the blood thinner heparin. The study will involve more than 100 sites around the world participating in a research effort with various governments, drug companies, universities and others to speed coronavirus therapies.A second study in COVID-19 patients not sick enough to need hospitalization will test various strategies against placebo pills: baby aspirin or low or regular doses of the anti-clotting drug apixaban, sold as Eliquis in the United States. The goal there is preventing blood clots or hospitalization.A third study starting later will test blood thinners for people who have recovered and no longer test positive for the coronavirus. Evidence is building that they may remain at higher risk for blood clots. 1538

WASHINGTON (AP) — As coronavirus cases rise in more than half of the states, the Trump administration is urging the Supreme Court to overturn the Affordable Care Act, otherwise known as Obamacare.The administration’s high court filing Thursday came the same day the government reported that close to half a million people who lost their health insurance in the economic shutdown to slow the spread of COVID-19 have gotten coverage through HealthCare.gov.The administration’s legal brief makes no mention of the virus.Some 20 million Americans could lose their health coverage and protections for people with preexisting health conditions also would be put at risk if the court agrees with the administration. 716

WASHINGTON (AP) — Joe Biden’s scientific advisers will meet with vaccine makers in coming days as the presidential transition remains stalled because of President Donald Trump’s refusal to acknowledge that he lost the election. The government’s top infectious disease expert says that delayed handoff to the next administration is especially problematic during a public health crisis. Dr. Anthony Fauci tells CNN, “Of course it would be better if we could start working with them." Biden’s outreach to the vaccine manufacturers comes as the coronavirus pandemic in the United States has entered perhaps its most dangerous phase. The seven-day rolling average for new daily cases stood at 145,400 on Saturday, according to data from Johns Hopkins University. 765

Vladimir Putin is set to extend his power in Russia for another six years after winning Sunday's presidential election with the majority of the vote, exit polls show.Putin was widely expected to win his fourth term as President, with no meaningful opposition in the running and his?fiercest opponent, Alexei Navalny, barred from the race.Exit polls are not final, and official results will be released in coming hours.Putin has dominated Russian politics for 18 years and was already the country's longest-serving leader since Soviet dictator Joseph Stalin.Putin's critics have slammed the election as unfair, citing the Kremlin's tight control over the media, quelling of the opposition and restrictions on some election monitors to ensure a free vote.Opposition activists and the non-governmental election monitoring group Golos reported voting irregularities. By early evening Sunday, Golos had counted 2,000 incidents, including observers being prevented from carrying out monitoring.The vote was a huge logistical undertaking, taking place across Russia's 11 time zones over 22 hours, in around 97,000 polling stations, according to the Central Election Commission.There was little fanfare in the campaign period and Russian news was dominated by developments in political crises between Russia and Western powers. 1327

Walmart is making its opioid policy more strict, limiting the duration of such prescriptions and requiring that they be filled electronically.The company announced on Monday that within 60 days, it will only fill first-time acute opioid prescriptions for seven days or less nationwide, and it will limit the dosage to 50 morphine milligram equivalents, or MMEs, per day. The CDC publishes?MME conversion guides to help pharmacists figure out the right dosage for each type of prescribed opioid.There are more than 5,300 Walmart and Sam's Club locations in the United States.The new restrictions follow recommendations from the Centers for Disease Control and Prevention. A CDC study found that people who were prescribed at least one day of opioid therapy had a 6% chance of being addicted a year later — but for those prescribed eight or more days of treatment saw that chance spiked to 13.5%. The CDC also notes that patients who are prescribed higher dosages are more likely to die from an overdose.Some states already limit prescriptions to seven days or fewer. Walmart will go by state law when the cap is lower than one week.Walmart also said that starting in 2020, it will require e-prescriptions for controlled substances. The company explained that online prescriptions will help prevent prescription fraud and minimize error.The new measures are an extension of Walmart's efforts to fight the US opioid epidemic.In January, the company introduced a way to safely destroy leftover opioids at home. DisposeRx is a powder that, when combined with water and the pills, creates a gel that is difficult to remove from its container. The mixture can be thrown out at home or left at a drop off location. The company said on Monday that it will make DisposeRx available online.Plus, Walmart and Sam's Club pharmacists will continue to recommend the anti-overdose drug naloxone, which is available over the counter in some states, to customers who may be at risk of an overdose. They will complete a pain management curriculum by the end of August.Other companies are making similar efforts to help fight the epidemic.Aetna started waiving co-pays for the anti-overdose drug Narcan, a branded version of the naloxone nasal spray, and limiting first-time opioid prescriptions to seven days in January. And CVS Caremark, the prescription benefit manager for CVS Health, began capping first-time prescriptions at seven days in February.Purdue Pharma, which makes the opioid OxyContin, said in February that it will stop promoting the addictive painkiller to doctors.The CDC said in March that more than 63,000 Americans died of a drug overdose in 2016, and that nearly two-thirds of those overdoses involved either a prescription or illegal opioid, like heroin and fentanyl. 2830