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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) — San Diego Humane Society has placed 140 rats up for adoption after they were given up by a woman in Del Mar this week.The rats have undergone veterinary exams and tests and are "happy and ready" for adoption, the Humane Society says. Because rats are social animals, the society is only adopting them out in same-gender pairs unless the owner already has a rat.The rodents were given to SDHS after a woman's pet rats multiplied out of control while she was living out of her vehicle in Del Mar. The population eventually grew to more than 300 pet rats. The rats chewed through the vehicle's wiring, rendering it inoperable.RELATED: Del Mar neighbors aid woman living in car with 300 pet ratsNeighbors have since rallied around the woman, helping her tow her old vehicle, get a new car, and turn over the rats to SDHS. Many of the rats were pregnant females and are currently in foster care through the Humane Society. The 140 rats available now are males and non-pregnant females, according to SDHS."Although rats are not as common as other small rodents, they make great pets," SDHS said. "They are very social, smart and love to interact with humans ... They are very popular as classroom pets, because they like to interact with people."Rats eat pellets, veggies, and fruit and stay clean by grooming themselves, much like a cat, several times a day.If anyone is interested in adoption, the animals are available at Escondido, Oceanside and San Diego Humane Society locations for a pair.SDHS also recommends any pet owners in need of help contact them at 619-299-7012. 1601

SAN DIEGO (KGTV) - Rev. Al Sharpton will join local members of the National Action Network in a press conference Wednesday.Rev. Sharpton is scheduled to discuss Midterm elections, criminal justice reform, and "issues impacting communities of color in San Diego." Specifically, he is set to discuss an independent investigator working on cases involving police shootings and misconduct.Rev. Sharpton will be joined by the families Jonathan Coronel, Sergio Weick, Alfred Olango and James Lacey, who have been directly affected by police-related shootings in Southern California.Watch a Facebook live in the player below:  642

SAN DIEGO (KGTV) — San Diego City Council leaders will consider several measures aimed at lessening the impacts of the coronavirus pandemic in San Diego.Among the legislation are measures that place a moratorium on evictions due to non-payment from loss of wages due to COVID-19, prevent immigration enforcement operations at hospitals and other healthcare facilities, and provide relief from utility shutoffs or late fees because of non-payment due to coronavirus.“The COVID-19 pandemic is already causing harm throughout our communities and across our regional economy, impacting vulnerable families, individuals, and businesses,” City Council President Georgette Gómez said. “We must act immediately to protect those who most are at risk of devastating financial hardship.”The council will also request Gov. Gavin Newsom implement a temporary moratorium on residential evictions due to loss of wages caused by the outbreak.Council leaders also plan to request Mayor Kevin Faulconer enforce earned sick leave and minimum wage ordinances, place a temporary ban on vehicle habitation fees and impounds, and work with hotels to offer rooms to unsheltered individuals and families. 1187

SAN DIEGO (KGTV) — San Diego County started the rainfall season in October bone dry, but now the region is getting ready for another storm in time for Thanksgiving.San Diego's weekend will be great, cooling down on Monday before the storm arrives. Winds will pick up on Tuesday. Then, the surf will increase along the coast before the Thanksgiving storm arrives.The atmospheric river will potentially set up the stage for heavy rain, flash flooding, and thunderstorms during the major winter storm. Rainfall totals could average from 3-5 inches for the coast and valleys and 4-8 inches in the mountains. Snow levels will start out high around 8,000 feet. RELATED: Today's 10News weather forecastHere's how you can keep your pets safe with the cold weatherCold air will settle in Friday with snow levels dropping to 3,500 feet. That means snow could fall in Julian, Palomar, Mt. Laguna, and even Descanso. The best chance for snow will be Thursday and Friday.The chance of rain will begin late Tuesday, lasting through Thanksgiving Day and Black Friday. Often times San Diego is the envy of the nation, especially during the holiday. The region's warmest Thanksgiving happened in 2017, hitting 87 degrees. Last year the holiday took a chilly turn, plunging down to 58 degrees — just 4 degrees shy of San Diego's coldest Thanksgiving in 1919. Last year, San Diego also picked up 0.04 inches of light rain. The wettest Thanksgiving in San Diego's history received 1.26 inches in 2008, but the expected winter system this week could challenge that record.Traveling this ThanksgivingThe expected wet weather is especially important to consider, as this holiday expects to see the highest Thanksgiving volume on record for California travelers. The holiday will also be the second-highest travel volume nationally since 2000, according to the Automobile Club of Southern California.AAA says about 7 million Americans will be traveling 50 miles or more this Thanksgiving. Of that number, about 4.3 million are from Southern California.Of those Southern Californians, 3.7 million will travel by car, 500,000 by aircraft, and 123,800 will use other modes of transportation, like buses or cruise ships.RELATED:AAA provides tips on preparing vehicles for holiday travelTSA offers advice to travelers for Thanksgiving holiday weekendWith the influx or drivers, thousands of expected to run into problems on the road, according to AAA. The Auto Club says about 100,000 Californians and 368,000 nationwide will need roadside assistance for things like flat tires, dead batteries, or lockouts."This is the fourth Thanksgiving holiday period in a row that the percentage growth in air travel for Californians is higher than the growth in car travel, indicating continued consumer confidence in spending more for holiday trips," said Auto Club spokesperson Jeffrey Spring. "That's despite an average 7 percent increase in airfares over last year."AAA says the top five destinations for Southern California residents will be Las Vegas, San Diego, Mexico (cruises and resorts), the Grand Canyon and Lake Tahoe. 3099