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Experts say the finalization of a COVID-19 vaccine is in our near future. Dr. William Moss is a professor of epidemiology and the executive director of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health.“Remarkable progress has been made in the development of COVID-19 vaccines,” Dr. William Moss said.He says it typically takes five to 10 years to develop a vaccine, but with so much money and attention going toward COVID-19, he believes it’s likely we’ll have a vaccine by the end of the year.“I’m pretty confident that there will be a vaccine that will have an emergency-use authorization in the United States by the end of 2020,” Dr. Moss said.According to Dr. Moss, of the dozens if not hundreds of vaccine candidates in clinical trials, there are three vaccine candidates that have reached phase three. Phase three is when tens of thousands of volunteers test the vaccine to make sure it’s safe and effective.As of this week, we have optimistic news regarding phase-three efficacy results from biopharmaceutical company Pfizer – which has been collaborating with German company BioNTech.“Early preliminary results suggests that their vaccine is 90% or so effective in preventing mild to moderate or severe disease.”If the 90% efficacy data holds up after follow ups from participants in late November, Dr. Moss says he expects the FDA will rigorously review the data and approve the vaccine for distribution. That means health care workers and other high-priority groups would get the vaccine in December of this year, or early next year.“Pfizer says that they could have close to 50 million doses by the end of this year," Dr. Moss said. "Now remember their vaccine – as a number of the vaccine candidates do – requires two doses per individual. So, 50 million doses allows you to vaccinate about 25 million people.”Dr. Moss says the unprecedented investment in vaccine manufacturing will make it possible for the vaccine to be distributed so quickly. However, there are still quite a few logistical challenges since he says the Pfizer vaccine requires extreme cold temperatures as low as minus 117 degrees Fahrenheit.“So we need warehouses to store the vaccine that have freezers that can maintain that cold, we need transportation systems – planes, trucks – that can deliver the vaccine and keep it cold. And then at the site of distribution, we need to be able to keep these vaccines cold.”Therefore, he says it will likely take a lot longer for the general population to get the vaccine. He’s guessing not until the middle of 2021. Of course, the idea of saving lives with the help of a vaccine is very promising, but he says the greatest misconception is that we can go back to "normal" as soon as it’s distributed.“That by no means is going to indicate that we can go back to our pre-pandemic life," Dr. Moss said. "We will not know whether these vaccines stop transmission and we’re going to still need to wear masks, to wash our hands and physically distance even when vaccines become available.”Time and patience will be vital as we wait to see the long-term impacts of the vaccine in this pandemic. 3168

ENCINITAS (CNS) - A North County community leader who's known as a bicycle and pedestrian safety advocate was hit by a truck and seriously injured while riding her bicycle in Encinitas early Saturday.The crash happened shortly after 6 a.m. Saturday on North Coast Highway 101 near Phoebe Street, San Diego Sheriff's Lt. Dave Perkins said.The victim was Roberta Walker, executive director of the Cardiff 101 Main Street Association, The Coast News reported. Walker is known as a staunch defender of pedestrian and cyclist rights.She was taken to a hospital in critical condition, Perkins said. Walker suffered injuries to her brain and spine, as well as broken bones, according to The Coast News.Alcohol and drugs were not considered to be factors in the crash, Perkins said.Cardiff 101 Main Street is an organization that promotes "a safe and healthy environment" and "a walkable community that provides goods and services for local residents and visitors alike" in Cardiff-by-the-Sea, according to the organization's website.A biographical page on the website describes Walker as a passionate cyclist. She's known as a supporter of the proposed Leucadia Streetscape project, which would add roundabouts, bike lanes and sidewalks to a stretch of North Coast Highway 101, including the area where she was struck. 1319

ESCONDIDO, Calif. — The Golden State Killer arrest is shining the spotlight on a controversial DNA search known as Familial DNA.    In the summer of 2013, communities in southern California were gripped by fear amid a string of unspeakable crimes.An unknown culprit dubbed "The Creeper" entered five homes in Escondido and one in San Marcos, cutting screens, cutting the clothes of little girls and molesting them while they slept.The suspect left DNA at several scenes, but a search turned up no matches. Ultimately, the case went cold until detectives applied to the State Department of Justice for a DNA familial search.In 2015, the mystery DNA profile was linked to somebody already in the system, a close relative of the suspect."They were able to determine through a familial search who the suspect likely was," said Deputy District Attorney Ryan Saunders.That suspect was Gilbert Chavarria, who recently pleaded guilty to a host of charges. He was sentenced to 100 years to life in prison."Police did an excellent job gathering the evidence, but the leads were exhausted. Without the familial searches, we'd still be on our hands waiting," said Saunders.Amid concerns from privacy advocates, California Governor Jerry Brown in 2008 enacted a policy that familial DNA would be used only as a last resort.It's been rarely used. but did provide the break in several serial killer cases, including the Los Angeles-area Grim Sleeper case and in the Golden State Killer case. In the latter, the mystery DNA was linked to a familial profile from an ancestry website.Some law enforcement experts say the recent cases could lead to a lot more requests for the DNA search. Familial DNA also provided the break in the infamous BTK serial killer case in Kansas. 1854

EXETER, N.H. — A voter bared her arms, and more, after she was told she couldn't wear an anti-Trump shirt at a polling place and responded by whipping it off and doing her civic duty topless.The woman wore a "McCain Hero, Trump Zero" T-shirt at the polling place in Exeter, New Hampshire, on Tuesday's primary election.In New Hampshire, voters are not permitted to wear any "campaign material" inside a polling station. Moderator Paul Scafidi told the woman that she could not wear the shirt while voting, according to Sea Coast Online.Scafidi said the woman asked why another woman in the polling station was allowed to wear a shirt with an American flag while voting. Scafidi said he determined that an American flag shirt did not constitute as electioneering — a judgment call that he, as the moderator, is required to make.Scafidi then told Sea Coast Online that the woman asked if she should take her shirt off, even though she was wearing nothing underneath."I said, I'd rather she not," Scafidi said, according to Sea Coast Online. "But she took it off so fast, no one had time to react. So the whole place just went, 'woah,' and she walked away, and I let her vote. She could've just gone into the hallway and turned it inside-out."The woman could have faced public indecency charges, but Scafidi said he chose not to involve the police because he "didn't want to escalate the situation further." The woman put her shirt back on before she stepped out of the voting booth.According to InStyle, electioneering laws vary from state to state, but most prevent voters from wearing clothing that directly advocates for (or against) a particular candidate, party or issue while voting. The issue gets trickier when considering articles of clothing with more generic political slogans, like "Make America Great Again" or "Resist." Ultimately, it may come down to a poll worker's or moderator's discretion.Check with your local registrar before you hit the polls if you have any questions about a potentially-political article of clothing. Click here to find your local registrar's office. 2097

Fashion designer Hubert de Givenchy, a pioneer in high-end ready-to-wear clothing and famous for styling Audrey Hepburn's little black dress in "Breakfast at Tiffany's," has died at the age of 91, the House of Givenchy confirmed on Monday via its official Twitter account."The House of Givenchy is sad to report the passing of its founder Hubert de Givenchy, a major personality of the world of French Haute Couture and a gentleman who symbolized Parisian chic and elegance for more than half a century. He will be greatly missed," the company announced.His longtime partner, former haute couture designer Philippe Venet, revealed in a statement to AFP that Givenchy died in his sleep on Saturday.Givenchy entered the world of fashion in 1944 at the age of 17, training under Parisian designer Jacques Fath.Before long, he had moved on to designing for several major fashion houses including Robert Piguet, Lucien Lelong and Elsa Schiaparelli.Givenchy was in his mid-20s when he threw caution to the wind and launched his eponymous label in 1952. He maintained low overhead costs to keep down the prices of his designs.His first collection -- which championed the concept of separates and featured flawlessly detailed embroidered pieces, chic silk prints and sophisticated ball gowns -- immediately drew international recognition.From the off, he blazed a trail of innovation in the industry starting with his "Bettina blouse," named for popular French 1950s supermodel Bettina Graziani, which reintroduced tailored shirts into high fashion.But Givenchy was perhaps best known for his decades-long friendship with his muse Audrey Hepburn, which blossomed while she was filming her 1954 hit "Sabrina."Givenchy continued to style her outfits for "Breakfast at Tiffany's," "Funny Face" and "How to Steal a Million" and their friendship would endure until Hepburn's death from cancer in 1993."It was a kind of marriage," Givenchy told the UK's Daily Telegraph newspaper in 2015. "Little by little, our friendship grew and with it a confidence in each other," he added."There (was never) any criticism of the other person, no upsets."Enduring legacyOver the years, the haute couturier became a firm favorite of some of the world's most glamorous and highly admired A-listers.When Jackie Kennedy accompanied her husband to Paris in 1961, she turned to Givenchy to help dress her."It was not the same relationship or friendship that I had with Audrey," the couturier said in 2012 of his work with Kennedy. "The American people felt emotion for Jackie, but they preferred to have an American couturier design her dresses when they came to France for a state visit. Jackie asked for more than 10 or 15 pieces, saying 'I don't know if I can be dressed by a French designer.'"He continued: "We did all the fittings in secret. Then after the event at Versailles, Jackie sent me a little postcard to tell me that General de Gaulle gave her a very nice compliment. He said, 'Madame, this evening you look like a Parisienne.'"During his illustrious career, Givenchy also styled the likes of Elizabeth Taylor and Princess Grace of Monaco.Today, his label continues to be relevant and innovative, remaining incredibly popular with celebrity fans including Beyoncé, Kanye West and Rihanna. Beyoncé's love of the fashion house's style is well-known, with her having worn its creations to the last five Met Galas she attended between 2012 and 2016 (she didn't attend the gala in 2017). Fashion elite mourn 3498