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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959

LOS ANGELES (AP) — California health officials Tuesday urged consumers to stop vaping marijuana or tobacco products until investigators determine why hundreds of people nationwide have been sickened after using the devices.Ninety people with a history of vaping have been hospitalized for severe breathing problems and lung damage in the state, and two people have died. With no known cause, officials say consumers should refrain from vaping of any kind until investigations are completed."We are seeing something that we have not seen before," Acting State Public Health Officer Charity Dean said in a statement. "There are numerous unknown factors at this time, and due to the uncertainty of the exact cause, it is our recommendation that consumers refrain from vaping until the investigation has concluded."RELATED: Second vaping-related death in Kansas brings nationwide total to nineOver 500 cases have been reported across the U.S., and the Centers for Disease Control and Prevention is investigating the mysterious outbreak but has not yet identified a common electronic cigarette or ingredient as the culprit in the rash of illnesses.Symptoms can include chest pain, nausea, vomiting, diarrhea, fatigue, fever and weight loss.RELATED: 11 San Diego illnesses linked to vaping, officials sayIn its health advisory, the state Public Health Department specifically warned against using cannabis products from illegal dispensaries that could be holding tainted oil."Illegal cannabis dispensaries sell unregulated and untested cannabis products and absolutely should not be used," the agency said.RELATED: El Cajon to consider city ban on vapingLast week, Democratic Gov. Gavin Newsom announced that the state will spend million on a public awareness campaign about the dangers of vaping nicotine and cannabis products and step up efforts to halt the sale of illicit products.The Associated Press reported earlier this month that shops in downtown Los Angeles are openly selling packaging and hardware that can be used to produce counterfeit marijuana vapes that have infiltrated the state's cannabis marketplace. 2128

LODI, Calif. - An officer saved a man in a wheelchair mere seconds before an oncoming train passed by.The officer’s body camera captured the moment Wednesday morning when she spotted a man in a wheelchair stuck on the tracks in Lodi, California. The crossing arms were coming down and she jumped out of her patrol car.The video shows Officer Erika Urrea run to the man and pull the man from the chair. Both of them fall to the ground as the train passes by. 465

LONDON — Britain's health secretary says London and it surrounding areas will be placed under the highest level of coronavirus restrictions beginning Wednesday as infections rise rapidly in the capital. Matt Hancock said Monday that the government must take swift action after seeing “very sharp, exponential rises” in Greater London and nearby areas. Under Tier 3 restrictions, the toughest level, people can’t socialize indoors and bars, pubs and restaurants must close except for takeout.He said in some areas cases are doubling every seven days. Hancock told lawmakers that officials have identified “a new variant of coronavirus which may be associated with the faster spread in the south of England.” He said so far, about 1,000 cases of the variant have been identified in England, and they have alerted the World Health Organization. At this time, experts in the UK say it does not appear that the new variant of coronavirus is more transmissible, or more infectious or dangerous. "Huge efforts are ongoing at characterising the variant and understanding its emergence. It is important to keep a calm and rational perspective on the strain as this is normal virus evolution and we expect new variants to come and go and emerge over time," Professor Alan McNally, an expert at the University of Birmingham, told the BBC.The World Health Organization is among those studying the new virus strain, which has been identified in other countries in recent months. 1474

LOS ANGELES (AP) — California is sending every registered voter a mail-in ballot for the November election, but the state will also establish hundreds of locations for people who want — or need — to vote in-person. The decision to send every voter a mail-in ballot was prompted last month by health concerns tied to the coronavirus. Democratic Gov. Gavin Newsom says the state will also have a range of options for in-person voting. Counties must open a minimum of one in-person voting location for every 10,000 voters beginning the Saturday before Election Day. In-person voting locations must also allow voters to maintain physical distancing. RELATED:California to send all voters mail-in ballots this NovemberRNC sues Gov. Newsom over order to send mail ballots to all California votersThe executive order will also require ballot drop-box locations be available between Oct. 6 and Nov. 3. In-person voting sites will be available in county elections offices starting 29 days before Election Day.Republicans have been critical of the state's plans for November. 1073

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