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QINGDAO, Shandong, Dec. 26 (Xinhua) -- China's largest rail vehicle maker, CSR Corp. Ltd, over the weekend launched its first test train that features speeds reaching up to 500 km per hour.The six-car train with a fairshaped head is the newest in the CRH series. It has a maximum tractive power of 22,800 kilowatts, compared with 9,600 kilowatts for the CRH380 trains currently in service on the Beijing-Shanghai High-Speed Railway, which hold the world speed record of 300 km per hour.The grey-color train carrying testing and data processing facilities was designed and produced by CSR Sifang Locomotive & Rolling Stock Co., Ltd (Sifang Locomotive), a CSR subsidiary based in the coastal city of Qingdao in eastern Shandong province.Ding Sansan, the company's chief technician, said the concept of the the super-speed train design was inspired by China's ancient sword. The bodywork uses plastic materials reinforced with carbon fiber.Shen Zhiyun, a locomotive expert and academician with both the Chinese academies of sciences and engineering, said the testing of the super-speed train with speeds of up to 500 km per hour will provide useful reference for current high-speed railway operations.

BALI, Indonesia, Nov. 19 (Xinhua) -- Leaders of China, Japan and South Korea met here Saturday to exchange views on trilateral cooperation and regional and international issues of common concern.Chinese Premier Wen Jiabao, Japanese Prime Minister Yoshihiko Noda and South Korean President Lee Myung-bak were meeting on the occasion of a series of meetings for East and Southeast Asian leaders in this Indonesian resort city on Friday and Saturday.Speaking at the meeting, Wen said the cooperation between the three nations currently had good momentum, which was not only in line with the interests of the three sides but also contributed to the stability and development of the Asia and the world.Chinese Premier Wen Jiabao (L), Japanese Prime Minister Yoshihiko Noda (C) and Republic of Korea (ROK) President Lee Myung-Bak pose for photos during the Trilateral Summit Meeting for leaders of the three nations in Bali, Indonesia, Nov. 19, 2011.As the coordinator of next year's China-Japan-South Korea cooperation, China would like to further enhance high-level exchanges, policy coordination and strategic trust between the three countries, providing political impetus and promoting more advancement in trilateral cooperation, Wen said.He said next year marked the 40th anniversary of the normalization of diplomatic relations between China and Japan, and the 20th anniversary of the establishment of diplomatic relations between China and South Korea.In the meeting, Wen proposed the joint research into a free trade area between the three countries be completed this year, and negotiations start in 2012.Wen also suggested enhancing trilateral cooperation in the fields of transportation, finance and environmental protection, among many others.Also speaking at the meeting, the Japanese prime minister and the South Korean president said the cooperation between the three nations had seen remarkable achievement and its prospects were promising.The three sides should continue to deepen their exchanges and cooperation in various fields including economy and trade, finance, investment, disaster relief, culture, education and tourism, and strengthen the coordination in regional and international issues to promote common development, according to them.During the meeting, the three leaders also exchanged views on other regional and international issues of common concern.

WASHINGTON, Oct. 3 (Xinhua) -- Overweight or obesity may put children at three times greater risk for high blood pressure than those of normal weight, according to researchers from the Regenstrief Institute and Indiana University (IU) School of Medicine.Their study will appear in the November issue of Hypertension: Journal of the American Heart Association with advance online publication on Monday.More than 1,100 healthy Indiana school children were followed for nearly five years. The researchers found that when body mass index (BMI) reached or exceeded the 85th percentile for the age and gender of the child -- designated as being overweight -- the risk of high blood pressure nearly tripled. Obesity was defined as a BMI percentile higher than 95th. BMI is a measurement of body fat calculated from weight and height.Among study participants, 14 percent of overweight or obese children were pre-hypertensive or hypertensive, compared with 5 percent of normal weight children. These findings were consistent across age, gender and race.The average age at time of study enrollment was 10.2 years. Each child was assessed approximately eight times during the course of the study. All were healthy children and none were taking medication affecting blood pressure."Higher blood pressure in childhood sets the stage for high blood pressure in adulthood," said Regenstrief Institute Investigator Wanzhu Tu, professor of biostatistics at IU School of Medicine, who led the study. "Targeted interventions are needed for these children. Even small decreases in BMI could yield major health benefits."The researcher also found that leptin, a protein hormone which is involved in body weight regulation and metabolism, was positively associated with increased blood pressure in overweight and obese children.

WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."