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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.
ISTANBUL, May 3 (Xinhua) -- The world's water consumption will increase by 40 percent over the next two decades and efforts to meet this demand must increase radically, the secretary-general of the 5th World Water Forum said here on Tuesday.Oktay Tabasaran said in his opening speech at the World Water Forum that "water consumption will increase by 40 percent in the coming 20 years, reaching 6.9 trillion cubic meters per year ( compared with the 4.5 trillion used currently), and an amount of 200 billion U.S. dollars must be spent annually in order to afford this."He said such figures indicated the urgent need for countries to engage in efficient cooperation with each other to address water- related issues.Some 50 out of the world's 188 countries have serious concerns in providing drinking and irrigation water, due to careless and inefficient use of water, according to Ismail Ugur, the general director of Turkey's State Waterworks Authority."If we fail to come up with solutions, starting from 2015 there will be droughts (in many parts of the world) and people will start suffering from diseases caused by lack of water, as of 2025, " Ugur said.Ekmeleddin Ihsanoglu, head of the Organization of the Islamic Conference (OIC), said that ensuring reliable access to water is crucial to promoting peace and security in the Middle East, where many countries are facing dramatic declines in available water."In some regions of the Muslim world, water availability is predicted to be cut in half by 2050, even without taking into consideration the effects of climate change," he said in his opening speech.The OIC chief called for increased cooperation among member states and countries outside the region, announcing the group's progress in preparing its own "Water Vision" document and forming an OIC Water Council to address water-related concerns."In its first phase, the Water Vision will outline a framework of cooperation on water-related issues in terms of water-sharing experience, capacity development, technology transfer, water governance and institutional reforms," Ihsanoglu said.He cited the Friendship Dam, to be constructed on the Orontes River at the Turkish-Syrian border, as an excellent example of cooperation and peace among neighboring countries in the field of water.Charity Ngilu, minister for water and irrigation of Kenya, stressed the importance of water in promoting peace, especially in regions where water scarcity prevails."There have been many conflicts caused by water scarcity not only among African countries, but even within regions of the same country," She said, adding Kenya would ask Turkey for cooperation and assistance in water management and other related issues.

BEIJING, May 25 (Xinhua) -- A researcher with the Chinese Academy of Agricultural Sciences (CAAS) said Wednesday that plant hormones, if used properly, are not a risk to human health."Irregular use of plant growth substances may cause plants to grow excessively fast or affect the taste, but will not cause harm to human health," Ye Zhihua said in an interview with Xinhua.His remarks come after media reports in China about "exploding watermelons," caused by the excessive use of phytohormone, have aroused public concern over the safety of hormones that stimulate plant growth.Ye said plant hormones used to promote growth have the same or similar effects as natural plant hormones, and fruit and vegetables sold at the market carried limited residue of the hormones.More than 100 types of plant hormones, such as ethephon and gibberellin acid, are used in agriculture and forestry sectors around the world, Ye said, adding 38 types of plant hormones have been registered in China.For example, seven plant hormones including thidiazuron and nucleotide are approved for use on cucumbers in China. The purpose is to stimulate the growth of female flowers and increase fruit yields, Ye said.Ye added that China places plant hormones in the category of pesticides control, which means the hormones are subject to strict management from production to utilization.
SHANGHAI, March 17 (Xinhua) -- Lenovo Group and a subsidiary of Shanghai Media Group (SMG) signed an agreement on Thursday to create a firm that would provide mobile-Internet video services.BesTV New Media Co., a subsidiary of SMG, owns 51 percent of the venture, named Shanghai Video Cloud Company Limited, while Lenovo owns the remainder. The total investment of both parties in the new firm exceeded 10 million yuan (1.52 million U.S. dollars), according to the agreement.Lenovo is currently the largest personal computer maker in China. BesTV New Media is a provider of Internet Protocol Television (IPTV), mobile television and other forms of new media.
BEIJING, Jan. 24 (Xinhua) -- China has invested 115 billion yuan (17.45 billion U.S. dollars) on the South-to-North Water Diversion Project as of the end of last year, a senior official said Monday.E Jingping, director of the Office of the South-to-North Water Diversion Project Commission (SNWDPC) of the State Council, said construction on 40 projects began last year, marking a new annual record.No major accidents happened while constructing the projects last year, E said.The South-to-North Water Diversion Project is designed to divert water from the water-rich south of China, mainly the Yangtze, the country's longest river, to the country's arid northern regions. It will consist of three routes: an eastern, middle and western route. The project started with construction of the eastern route in 2002.Up until now, both of the eastern and middle routes were already under construction. The western route, meant to replenish the Yellow River with water from the upper reaches of the Yangtze through tunnels in the high mountains of western China, is still in the planning stage.About 330,000 people in Hubei and Henan Provinces will be relocated before the middle route is completed in 2014.
来源:资阳报