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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

Robert Mueller has been subpoenaed by the House Judiciary and Intelligence Committees to testify on July 17 to address the special counsel's probe into the 2016 election. Mueller previously said that his report would act as his testimony, and he would not say anything beyond what is in the report. “The report is my testimony. I would not provide information beyond that which is already public in any appearance before Congress," Mueller said last month.In his report, Mueller found that the Trump campaign had multiple contact with the Russian government during the 2016 election. Although Mueller concluded that the Russians' involvement in the election was illegal, the Trump's campaign ties to the Russians did not amount to a criminal conspiracy. Mueller's team also investigated a number of obstruction of justice allegations involving President Donald Trump. Mueller could not make a judgment on Trump's guilt as he said that Department of Justice guidelines suggest a sitting president cannot be criminally charged. 1038

Sen. Mitch McConnell (R-Kentucky) introduced a new bill Monday that would require anyone buying tobacco products — including e-cigarettes or vaping products — be 21 years old.The bill, which is co-sponsored by Sen. Tim Kaine (D-Virginia), would follow in the footsteps of 14 other states that have already raised the minimum age to buy tobacco products to 21."Youth vaping is a public health crisis," McConnell said on the Senate floor. "It's our responsibility as parents and public servants to do everything we can to keep these harmful products out of high schools."In 2018, the 594

Tamera Mason deals with four competing autoimmune diseases everyday, and her service dog Irene helps her stay on top of things.“She is a diabetic and Addison trained dog,” Mason said.Addison’s Disease is a disorder in which the body doesn’t produce enough hormones. It can be life threatening.“She has kept me safe,” Mason said. “And instead of having an Addison crisis about every six weeks, now in a year and a half I’ve only have two ICU visits. Both of which she predicted and was able to alert me for.”Dogs can learn to “alert” their owners when they smell a certain trigger, like low blood sugar, if properly trained. Irene bumps Mason’s leg.“Irene is 20 to 30 minutes ahead of when the glucose monitor said I was in trouble,” Mason said.Given Mason’s condition and her full time job at an emergency department, it can make all the difference. “I have been very blessed with a dog who truly has superpowers,” Mason said.She got Irene from a nonprofit called Service Dogs of Virginia. They train dogs with different skills based on the future owner’s needs. “We don’t train the dogs to smell the odor, they do that because they’re dogs and they have a nose. What we do is train them to tell us when they smell that odor,” Peggy Law, the founder of the organization, said.Law calls them "toddlers with superpowers. She saw the need for service dogs in her community, saying the demand grew enormously. With that demand comes more businesses entering the industry, but not always for the right reasons. Service dog companies and trainers are not monitored or regulated by any government agency. Instead, a nonprofit coalition has formed in its place.“We are really regarded as the global leaders of the industry for setting standards,” Chris Diefenthaler, the executive director of Assistance Dogs International (ADI), said.ADI has come up with its own peer-review accreditation process to help combat fraud.“It is a very thorough, comprehensive evaluation,” Diefenthaler said.ADI had 273 member organizations worldwide in 2018. In that year, they helped place more than 7,700 service dogs, four percent were diabetic alert dogs. Irene was trained through an ADI-accredited facility.“We have a reasonable sense of when I go to bed at night, being able to wake up,” Mason said.Some aren’t so lucky.“We found out he had skin issues which ended up being from autoimmune diseases from being overbred,” Michelle Ninstant said. Ninstant was desperate to find ways to help her son who had just been diagnosed with diabetes, and heard how service dogs could help.“My son, Zack Johnson, was diagnosed with Type 1 Diabetes back in 2012,” she explained. “He was very brittle, so no matter how much we gave him to carb him up and bring his sugars up he could drop 20, 30 seconds after that.”She found a company selling service dogs, with a price tag of ,000. After waiting nine months, she received Alan, a 13-week-old service dog who was supposed to come with basic training. Within days, Alan was shoeing troubling symptoms, and still had not learned the basics like “sit” or “stay”.“While we’re trying to learn about diabetes in general and then add a service dog onto it, add my sons health issues onto it,” the mother explained. “He’s part of your family so you just don’t want to send him back.”She said in the first year alone, vet bills totaled close to ,000 as they figured out what was causing Alan’s skin and immunity problems.Ninstant ended up training Alan herself with some help, and on multiple occasions Alan helped save Zack.But six years later, you can still see Alan struggle with skin problems and itching.“Alan’s part of our family,” Michelle said.Service Dogs of Virginia keeps up with their clients every year. “We want to make sure they’re doing all the things that they need to to make sure the dog is working well,” Law said.While Law said a service dog isn’t the right solution for everyone, there are ways to make sure you are buying from a trustworthy organization. “I think you have to ask a lot of questions,” she said. 4059

Some Kentucky coal miners and their families are standing on train tracks to prevent a train loaded with coal from leaving. They say they worked since Dec. 16 without being paid. The tracks lead from Quest Energy in Pike County. 241