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Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730
SAN LUIS OBISPO, Cali. – It’s harvest time on California’s Central Coast and winemaker Jean-Pierre Wolff has seen a big drop in production since last year. “This year, the harvest is below average,” he said. “Some of my older vines did suffer from salt toxicity and have been steadily declining.” Wolff owns and operates the award-winning Wolff Vineyards. He says climate change is affecting his grapes and that he has the records to prove it. “Absolutely, I have my lab book where I describe extensively the harvest and the sugar levels of the grapes,” he said. “So, definitely I see these changes.” Wolff says the changes are linked to extreme weather like longer droughts, hotter summers and milder winters. “I’ve been farming here for 20 years,” he said. “Years ago, I didn’t have to worry about sunburns on my grapes, now I do.” Less rain means more reliance on irrigation, which Wolff says is cutting into his and other wineries’ bottom lines. “If you take the Central Coast, which is defined from the Bay Area to Ventura County, 86% of the water use is from ground water extraction,” he said. “So clearly, that’s not sustainable if we have to offset.” At nearby California Polytechnic State University San Luis Obispo, they have a growing viticulture program. Cal Poly professor Federico Casassa, Ph.D. says climate change is altering wine agriculture across the world. “Heatwaves are extremely pervasive not just in California but in Australia, in South America, and increasingly in Europe as well,” he said. Despite the impact, Casassa says climate change doesn’t mean doomsday for the wine industry. “My point is global warming and climate change are a reality,” he said. “But the effect that we see on grapes is not only due to global warming, it’s due to the fact that we grow better grapes." Now, Casassa is teaching better and more sustainable practices to viticulture students saying sustainability is not a destination but rather a journey. "Climate change is here and global warming is part of climate change,” he said. “But we are going to adapt.” Adapting, just like Wolff is doing. “I’m sort of here trying to beat the clock so to speak,” he said. To help protect his harvest, Wolff is now replanting a big portion of his vineyard and watering them with a new type of subsurface irrigation. “Instead of irrigating above ground through this drip line I connect with a little spaghetti hose and this pipe goes 3 feet below ground to the root zone,” he said. And while he might not be able to change the climate, Wolff does plan on changing his practices. 2608

A 5-year-old child suffered life-threatening injuries when, according to witnesses, a man either threw or pushed the child from the third floor of the Mall of America in Bloomington, Minnesota, police said Friday.Bloomington police Chief Jeff Potts told reporters that police were called to the mall at 10:17 a.m. local time, and initial information suggested a child had fallen from the third level of the mall's interior to the first level.Additional information from witnesses indicated the 5-year-old might have been pushed or thrown, Potts said.Police officers gave the child first aid along with witnesses, Potts said."The child did suffer significant injuries," he said. "The child has been transported to the hospital and has been receiving care." 767
A beer vendor working last Sunday's Miami Dolphins game was arrested this week after charging a fan 4 for two beers, the Miami Herald 149
WASHINGTON, D.C. -- Streets are far emptier than normal in cities and towns across America. It’s the most visual example of how the coronavirus is impacting daily life. At the root of that: orders to stay home. “The authority lies with the governor and in a number of jurisdictions that authority can also be devolved down to mayors,” said Meryl Chertoff, executive director of Georgetown Law’s Project on State and Local Government Policy and Law. She said things like stay-at-home orders, curfews and non-essential business closings, all have legal footing. “There is some question as to whether these are voluntary at this point, or whether they are mandatory, but there is no doubt that if you took these to court right now, they would be sustained by a court,” she said. They are also enforceable, she said. If you were to break the law, you’d likely be charged with a misdemeanor. However, Chertoff said there is something even bigger she is keeping an eye on. “What I am more concerned about, candidly, are the violation of civil rights of individual and loss of the right to travel,” she said. “So, one of the things that I've been thinking about is what about the right to cross state lines.” There are a growing number of state rules now in place about travel. Hawaii has asked all visitors to stay away for 30-days. Alaska wants anyone entering the state from the “outside” to self-quarantine for 14 days. The governor of Texas is now ordering people coming in from New York City or New Orleans to self-quarantine for 14 days. Florida’s governor asked people traveling in from New York – or who have in the past three weeks—as well as Louisiana, to also self-quarantine. “This is important because, after all the hard work, we don’t want it to now to get seeded, as people flee kind of the ‘hot zone,’” said Gov. Ron DeSantis, R-Florida. Whether any of travel requests or restrictions are enforceable is a question, Chertoff said, as similar orders that had come before the courts in previous years only applied to an individual, or a small group. “What enforcement capacities the states have is an open legal question because we've never been in a situation where there are large numbers of people potentially infected,” she said.It’s a situation that the nation might be forced to grapple with in the weeks – and possibly months – to come. 2365
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