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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A hiker fell to his death on Monday while ascending Yosemite National Park's famous Half Dome trail, the US National Park Service said.The hiker was on the trail's Half Dome cables, the park service said in a statement. He was hiking with another person during thunderstorm activity around 4:30 p.m. when he slipped and fell.The cables take hikers up the last 400 feet to the summit of Half Dome, which rises nearly 5,000 feet above California's Yosemite Valley.Park rangers were notified and went to the scene to assist the second hiker, the NPS said. The missing hiker's body was found around 1 p.m. Tuesday.His identity will be released after his family is notified.The death is the first on the Half Dome cables since 2010 and the first visitor fatality in 2018, the park service said. 797

A former student and three current students have been arrested and charged for their involvement in a prank that sent a student riding a dirt bike down a hallway at GlenOak High School in Canton, Ohio.According to officials at the Stark County Jail, all four were arrested for taking part in the prank that allowed a student to zoom through the hall on a dirt bike. The prank sent the school into a lockdown.The school said the incident has raised security concerns. One person involved, Eloy Lopes, 18, isn't a student at the school anymore."Our staff at GlenOak acted swiftly in addressing the immediate safety concerns as a result of the prank," a school representative school said in an email.Lopes was criminally charged with inducing panic with a reckless disregard for others, according to the sheriff. The sheriff's report said he was charged with criminal trespassing because he is not a current student at GlenOak. According to authorities, he held a door open for the dirt bike rider. The three students involved, a 17-year-old male and two 18-year-old males, were also arrested and charged with inducing panic with a reckless disregard for others for their involvement in the prank, according to authorities.The school has not addressed the status of the three current students, nor has it said whether or not security policies will change moving forward. 1515

A California police officer was charged Wednesday in connection with a fatal shooting at an Oakland-area Walmart store in April.San Leandro Police Officer Jason Fletcher was charged with voluntary manslaughter in connection with an incident where he fatally shot 33-year-old Steven Taylor on April 18.According to the Alameda County District Attorney's office, a security guard at the store called police when Taylor tried to leave San Leandro Walmart with a baseball bat and a tent without paying.Fletcher responded to the call and approached Taylor as he entered the store. The officer tried to grab the baseball bat from Taylor, and when he couldn't get control of the bat he drew his stun gun.After firing the stun gun, Taylor stumbled forward with the bat sitll in his hand. According to body camera footage, Fletcher repeatedly asked Taylor to drop the bat. Fletcher then fired his gun once, a shot that proved to be fatal.In its charging statement, the District Attorney's office, claimed that Taylor "posed no threat of imminent deadly force or serious bodily injury" to the officers or anyone else in the store because he had "clearly experienced the shock of the taser as he was leaning forward over his feet and stumbling forward."Fletcher's lawyer, Michael Rains, told the San Francisco Chronicle that he was "very disappointed" that the officer had been charged and that the charges were "undeserved."The decision to file the criminal complaint was made after an intensive investigation and thorough analysis of the evidence and the current law," Alameda County District Attorney Nancy O'Malley said.Lee Merritt, an attorney for Taylor's family, told NBC News that Taylor was experiencing a mental health crisis at the time of the shooting.Fletcher will be arraigned on Sept. 15 at a county courthouse in Dublin, California. 1845

A former assistant manager of a Michigan PetSmart has filed a lawsuit in which he claims he was fired for enforcing a store rule and a state-wide mandate requiring customers to wear a mask.Alex Brothers says he called police on July 19 when he saw a customer without a mask at the chain's store in Midland. According to Brothers' attorney, Jennifer McManus, the maskless customer was carrying a gun while shopping in the store."Because the man was openly carrying a weapon, my client decided the smartest course of action was to contact law enforcement about the fact the man was not wearing a mask, as required under the governor's executive order," McManus said.Midland police escorted the man from the store without incident. Two days later, PetSmart fired Brothers, who had worked at the store since 2015 and reportedly had an "excellent" performance record."He was told, 'Well, we know you feel really strongly about this mask issue,' and that was said during the termination meeting," McManus said.Michigan is one of many states that have adopted mandates requiring masks in public. But enforcement of those mandates often falls to retail or restaurant employees — and there have been several incidents in Michigan where such confrontations have ended in violence.In July, a dispute over masks led to a police-involved shooting near Lansing, Michigan. Two months earlier, a woman in nearby Macomb County, Michigan, was accused of attacking a worker after refusing to wear a mask. Also in May, 43-year-old Calvin Munerlyn was shot in the head after asking a family to put on masks before entering a Family Dollar in Flint, Michigan.McManus said those headlines were at the top of her mind when she heard about Brothers' case."Terminating your employee for trying to do their job in these unprecedented times is really unconscionable," McManus said. "It's an untenable position where these employees are choosing between their safety and their paychecks."Brothers is suing PetSmart for wrongful termination."Not only was Alex enforcing the governor's executive order, but he was attempting to enforce the store's own policy," McManus said.When asked for comment about the case, PetSmart said the store does not comment on pending litigation.This story was originally published by WXYZ in Detroit, Michigan. 2318