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The Federal Aviation Administration has issued a safety alert about flying with dry ice onboard, in anticipation of the huge nationwide distribution project anticipated to start in the next few days once the Pfizer COVID-19 vaccine is approved for use.The Pfizer and Moderna vaccines both need to be kept at extremely cold temperatures, requiring the use of dry ice during transit.Dry ice is frozen carbon dioxide that is pressed into blocks or pellets. It doesn’t melt into a liquid, it moves directly from a solid to a gas and that process can happen quickly at high altitudes.That can cause problems onboard a plane, such as causing the plane to weigh less at times during the flight and change its center of gravity.“CO2 sensors installed or carried in the aircraft or worn by the pilots and other crewmembers will assist the operator and crew in recognizing hazardous concentrations of CO2 and implementing effective risk controls,” the FAA’s safety alert recommends.In addition, they encourage maximum ventilation onboard while on the ground and in the air, asking crewmembers to check air conditioning units and auxiliary power units before flight.Exposure to elevated levels of CO2 can cause drowsiness or dizziness, and higher levels can impact breathing eventually leading to hypoxia and death.The FAA also recommends that “pilot training on specific conditions and procedures can improve pilot decision-making in the event of a CO2 detector alert or other system abnormalities.”Friday morning, Health and Human Services Director Alex Azar said Americans could begin getting the COVID-19 vaccine next week once the FDA and CDC give it emergency use approval. 1676

The CIA has determined that Saudi Crown Prince Mohammed bin Salman personally ordered the killing of journalist Jamal Khashoggi, despite the Saudi government's denials that the de facto ruler was involved, according to a Washington Post report.Citing people familiar with the matter, the Post reported Friday that the CIA reached its conclusion by examining several sources of intelligence. According to the Post, US officials have high confidence in the CIA's assessment.A spokesman for the CIA declined to comment to the Post. The Saudi government has denied bin Salman's involvement in Khashoggi's death.Fatimah Baeshen, a spokeswoman for the Saudi Embassy in Washington, told the newspaper that the claims in the CIA's "purported assessment are false.""We have and continue to hear various theories without seeing the primary basis for these speculations," she told the Post.Khashoggi, a former Saudi royal insider who became a critic of the country's government, went missing in October after he visited the Saudi consulate in Istanbul to obtain papers for his upcoming marriage. The Saudi government offered changing explanations for Khashoggi's disappearance.Included in the US intelligence analyzed by the CIA was a phone call the prince's brother Khalid bin Salman made to Khashoggi, encouraging the journalist to make the trip to the consulate to get the documents, according to the Post. Sources told the Post that Khalid made the call at his brother's command.Khalid denied the Post's reporting, saying on Twitter that he had never spoken to Khashoggi by phone."I never talked to him by phone and certainly never suggested he go to Turkey for any reason. I ask the US government to release any information regarding this claim," Khalid said.He said the last contact he'd had with Khashoggi was via text in October 2017.Baeshen told the Post that Khalid, who is the Saudi ambassador to the US, and Khashoggi never discussed "anything related to going to Turkey."The CIA also examined an audio recording from inside the Saudi consulate provided by Turkey and a phone call placed from inside the consulate after Khashoggi was killed, according to the Post.Maher Mutreb, an alleged member of the Saudi hit team and a security official for the crown prince, placed the phone call to a top aide for bin Salman informing the aide that the job had been done, people familiar with the call told the newspaper.According to the Post, the CIA also based its conclusion on its evaluation of bin Salman as a leader who is involved in minor matters.The CIA does not know the location of Khashoggi's remains, according to the Post.The Trump administration on Thursday?imposed penalties on 17 individuals over their alleged roles in the killing of Khashoggi. Khashoggi's assassination has created a crisis for the Trump administration and drawn attention to President Donald Trump's business ties to Saudi Arabia and the relationship between bin Salman and Trump's son-in-law and senior adviser, Jared Kushner.Earlier Thursday, the Saudi Public Prosecutor's Office said 11 people had been charged for their involvement in the death of Khashoggi, adding that five are facing capital punishment for being directly involved in "ordering and executing the crime."Khashoggi was killed following "a fight and a quarrel" at the Saudi consulate, the prosecutor's office claimed. Prosecutors said Khashoggi was tied up and injected with an overdose of a sedative that killed him. Then, according to prosecutors, his body was dismembered and removed from the consulate by five people. 3617

The first round of the NFL Draft got underway Thursday evening and Oklahoma quarterback Baker Mayfield was selected as the first overall draft pick by the Cleveland Browns. Mayfield will likely take over as Cleveland's starting quarterback in the fall after the Browns finished the 2017 season with a winless 0-16 record. Mayfield was a three-year starter at Oklahoma after starting one season for Texas Tech. He threw for 131 touchdowns over his four collegiate years, which is fourth all time in NCAA Division I history. According to most NFL Draft experts, five college quarterbacks will likely be selected in the first round on Thursday. The group includes USC's Sam Darnold, Oklahoma's Baker Mayfield, Wyoming's Josh Allen, UCLA's Josh Rosen and Louisville's Lamar Jackson.  807

The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499

The boy who made headlines when he was photographed hugging an officer during a 2014 protest against police brutality is missing after his family's SUV plunged 100 feet off a coastal highway in California, officials said Wednesday.The bodies of Jennifer and Sarah Hart, of Washington, and three of their six children, were found Monday in and around the vehicle, which landed on its roof in the Pacific Ocean, Mendocino County Sheriff Tom Allman said. Their three other children, including 15-year-old Devonte, are missing. 531

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