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New results on a possible COVID-19 vaccine from Oxford University and drugmaker AstraZeneca suggest it is safe and about 70% effective.Some experts say that shows it is likely to win approval, but questions remain about how well it may help protect those over 55. That's a key concern for a vaccine that health officials hope to rely on around the world because of its low cost, availability and ease of use.Partial results from tests of the vaccine in the United Kingdom, Brazil and South Africa were published Tuesday by the medical journal Lancet.“Today, we have published the interim analysis of the Phase III trial and show that this new vaccine has a good safety record and efficacy against the coronavirus,” said Professor Andrew Pollard, Director of the Oxford Vaccine Group and Chief Investigator of the Oxford Vaccine Trial. “We are hugely grateful to our trial volunteers for working with us over the past eight months to bring us to this milestone.”Researchers claim the vaccine protected against disease in 62% of those given two full doses and in 90% of those initially given the half dose. However, independent experts have said the second group was too small — 2,741 people — to judge the possible value of that approach and more testing is needed.The interim analysis for efficacy was based on 11,636 participants accruing 131 symptomatic infections from the Phase III trials.In addition to the Oxford led program, AstraZeneca is conducting a large study in the US and globally. In total, Oxford University and AstraZeneca expect to enroll more than 60,000 participants globally.The company says it’s also making progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval. The vaccine can be stored, transported and handled at normal refrigerated conditions for at least six months and administered within existing health care settings. 1940

NEW YORK (AP) — The one-time bookselling giant Barnes & Noble is being acquired by a hedge fund for 6 million.The national chain that many blamed for the demise of independent bookstores has been ravaged by Amazon.com and other online sellers. Independent bookstores have also persisted in the face of digital publishing.The company said in October that it might put itself up for sale after it was approached by a number of potential buyers, including founder Leonard Riggio who opened Barnes & Noble stores across the country and turned it into a superstore.Barnes & Noble said Friday that it's being acquired by Elliott Management for .50 per share, an approximately 9% percent premium to the company's Thursday closing stock price. Elliott bought the U.K. bookseller Waterstones in June 2018.Waterstones CEO James Daunt will also take on the role of CEO at Barnes & Noble.The sale, valued at about 3 million including debt, is targeted to close in the third quarter if approved by regulators and shareholders.Shares of the New York company jumped 11% before the opening bell. 1111

NOANK, Ct. -- As a humid summer breeze blew across the bow of the oyster boat Marc Harrell was standing on, he looked out toward Long Island Sound and could see some signs that the nation’s economy is recovering.Harrell has spent most of his life fishing those waters for oysters under the guidance of Captain Jim Markow, both men are the backbone of Mystic Oysters, a family owned business that’s been around for decades.“Our business hasn’t completely rebounded yet, it’s still going to be some time before it does,” Harrell said as he dropped an oyster dredge off the side of the boat.In Noank, Connecticut, the headwaters of the Atlantic Ocean come crashing into the Mystic River. The combination of saltwater and fresh water creates what most in the coastal community say are some of the best oysters in the world.But the coronavirus outbreak has been threatening a way of life that’s been a part of this community for generations. It’s a pandemic impacting both land and sea.“We don’t know what’s going to happen and we’re still not 100% optimistic that everything is going to be the same once this is all done,” Markow said.For the better part of 40 years, Markow has operated Mystic Oysters. The small family-owned company prides itself on harvesting oysters directly from their own oyster beds and shipping them directly to restaurants and suppliers up and down the East Coast. But as countless restaurants closed because of the coronavirus, Mystic Oysters no longer had a customer base.Like so many other small businesses across the country, COVID-19 has forced Mystic Oysters to reinvent themselves. The company has started selling directly to consumers, harnessing social media and word-of-mouth to bring customers directly to the docks to buy oysters as fresh as they come. They’ve even started coordinating with other small businesses and fisherman to hold farmers’ markets and pop-up sales tents around the area.Revenue is still down considerably but Markow sees a future in their new business model.“It’s exciting to see the opportunities that are out there that we weren’t aware of,” he said. “We were forced into a situation to reinvent our business and I think in the long run it’ll be a positive, in the short run though, definitely scary.”Experts say that kind of ingenuity and creativity is something other small businesses can emulate as they try to navigate the uncertainty surrounding the virus.“That’s always been the staple of small business, finding those market opportunities and working with the resources they have to survive,” said Holly Wade, who serves as a researcher with the National Federation of Independent Businesses.As for Mystic Oysters, they see diversification as a way forward. For the first time in the company’s history they’ve even started selling fresh lobsters directly to consumers. Markow hopes other small business owners who might be struggling see what they’re doing here and find hope for a future rebound.“Don’t give up, keep thinking. There’s a lot of opportunities out there if you want to be creative.” 3071

NEW YORK (AP) — It's OK to eat some romaine lettuce again, U.S. health officials said. Just check the label.The Food and Drug Administration narrowed its blanket warning from last week, when it said people shouldn't eat any type of romaine because of an E. coli outbreak. The agency said Monday that romaine recently harvested in Arizona, Florida, Mexico and California's Imperial Valley is OK to eat. It says romaine from those places wasn't yet shipping when the illnesses began.It says the tainted romaine appears to have come from the Central Coast region of California.The produce industry agreed to start putting harvest dates and regions on labels. For romaine that doesn't come in packaging, grocers and retailers are being asked to post the information by the register.The FDA warned Americans not to eat romaine that isn't labeled with that information, and it said it had commitments from the industry that such labeling will become standard for romaine. It also noted hydroponically grown romaine and romaine grown in greenhouses isn't implicated in the outbreak.The labeling arrangement was worked out as the produce industry called on the FDA to quickly narrow the scope of its warning so it wouldn't have to waste freshly harvested romaine. An industry group said people can expect to start seeing labels as early as this week. It noted the labels are voluntary, and that it will monitor whether to expand the measure to other leafy greens and produce.Robert Whitaker, chief science officer of the Produce Marketing Association, said labeling for romaine could help limit the scope of future alerts and rebuild public trust after other outbreaks."Romaine as a category has had a year that's been unfortunate," Whitaker said.The FDA still hasn't identified a source of contamination in the latest outbreak. There have been no reported deaths, but health officials say 43 people in 12 states have been sickened. Twenty-two people in Canada were also sickened.Even though romaine from the Yuma, Arizona, region is not implicated in the current outbreak, it was blamed for an E. coli outbreak this spring that sickened more than 200 people and killed five. Contaminated irrigation water near a cattle lot was later identified as the likely source.Leafy greens were also blamed for an E. coli outbreak last year. U.S. investigators never specified which salad green might be to blame for those illnesses, which happened around the same time of year as the current outbreak. But officials in Canada identified romaine as a common source of illnesses there.The produce industry is aware the problem is recurring, said Jennifer McEntire of the United Fresh Produce Association."To have something repeat in this way, there simply must be some environmental source that persisted," she said. "The question now is, can we find it?"Growers and handlers in the region tightened food safety measures after the outbreak this spring, the industry says. Steps include expanding buffer zones between cattle lots and produce fields. But McEntire said it's not known for sure how the romaine became contaminated in the Yuma outbreak. Another possibility, she said, is that winds blew dust from the cattle lot onto produce.McEntire said the industry is considering multiple theories, including whether there is something about romaine that makes it more susceptible to contamination. Compared with iceberg lettuce, she noted its leaves are more open, thus exposing more surface area.Romaine harvesting just recently began shifting from the Central Coast growing regions in central and northern California to other regions. Since romaine has a shelf life of about 21 days, health officials said last week they believed contaminated romaine could still be on the market or in people's homes.Food poisoning outbreaks from leafy greens are not unusual. But after a 2006 outbreak linked to spinach, the produce industry took steps it believed would limit large scale outbreaks, said Timothy Lytton, a Georgia State University law professor. The outbreak linked to romaine earlier this year cast doubt on how effective the measures have been, he said.But Lytton also noted the inherent risk of produce, which is grown in open fields and eaten raw.The FDA said the produce industry also agreed to consider longer-term labeling options that would help identify and trace leafy greens.___The Associated Press Health & Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content. 4582

NEW YORK (AP) — Citigroup's Jane Fraser will become the first woman ever to lead a Wall Street bank when she succeeds CEO Michael Corbat in February. The New York bank announced the succession Thursday. Fraser is currently head of Citi's global consumer banking division, a major part of the bank that oversees checking and savings accounts but also Citi's massive credit card business. For 16 years, Fraser has worked in various departments within Citi:- 2015-19: Chief Executive Officer of Citi’s Latin American region.- 2013-15: Chief Executive Officer of the U.S. Consumer and Commercial Banking and CitiMortgage. - 2009-13: Chief Executive Officer of Citi's Private Bank. - 2007-09: Global Head of Strategy and Mergers & Acquisitions.In 2004, she joined the company in its Corporate and Investment Banking division.She previously worked at McKinsey & Company, Goldman Sachs, and Asesores Bursátiles.Fraser also serves as a member of the Board of Dean’s Advisors at Harvard Business School and Stanford University’s Global Advisory Council. She's also a member of the Council on Foreign Relations.She earned her M.B.A. from Harvard Business School and an M.A. in economics from Cambridge University.Fraser's climb to the CEO role is a major accomplishment in an industry long dominated by men. Corbat led Citigroup for eight years, rebuilding the company after it nearly collapsed during the Great Recession and 2008 financial crisis.Corbat had been with the company for 37 years. 1500

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