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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.
BEIJING, Feb. 10 (Xinhua) -- More than 9,300 kidnapped children in China have been rescued since April 2009 since a nationwide campaign was launched to crack down on human trafficking, according to the Ministry of Public Security Thursday.In a statement, the ministry encouraged the involvement of civilians in providing clues to help the police rescue minors -- especially those being abused and forced to beg on the streets.In less than three weeks, a Chinese microblog called "Street Photos to Rescue Child Beggars" attracted 175,000 followers and posted more than 2,500 images of begging children online for parents to identify.The blog was set up last month by a professor with the Rural Development Institute of the Beijing-based China Academy of Social Sciences. It has helped rescue six children so far.However, the ministry noted in the statement that children kidnapped to become beggars took up only a small portion of all cases of child beggars. In most cases, children were taken to beg along with their parents or relatives.The ministry has urged police authorities across the country to closely cooperate with civil affairs, urban management and health departments in apprehending people who force children to become beggars.
MOSCOW, Jan. 25 (Xinhua) -- China condemned the terrorist attack at Moscow's Domodedovo Airport that killed 35 on Monday, visiting Chinese State Councilor Dai Bingguo said on Tuesday."We have learned that a terrorist attack occurred at the Domodedovo Airport yesterday. We are simply shocked by this news. We condemn this terrorist attack," Dai said when meeting with Russian Foreign Minister Sergei Lavrov.During their meeting, Dai and Lavrov exchanged opinions on bilateral ties, regional situation and issues concerning the Shanghai Cooperation Organization and others.Dai met with Russian President Dmitry Medvedev and participated in the fifth round strategic security talks with Russian Security Council Secretary Nikolai Patrushev on Monday.
BEIJING, March 10 (Xinhuanet) -- Cigarette displays in shops will be banned and tobacco companies may also be forced to make their products in plain wrappers in an attempt to stop people from smoking, announced the UK government Thursday.The prominent displays and attractive packaging of tobacco have long provided shopkeepers with stable income, keeping addicts hooked and quitters tempted.However, the government's move that will begin as early as spring next year will keep cigarettes hidden away and make it just a tad more difficult for smokers to find their fix."Nearly all adult smokers started smoking before they turned 18 and every year, over 300,000 children under 16 try smoking," said Chief Medical Officer Sally Davies."Smoking is undeniably one of the biggest and most stubborn challenges in public health. Over eight million people in England still smoke and it causes more than 80,000 deaths each year," Health Secretary Andrew Lansley said in his statement on the new law.Now, this move has drawn predictable responses from both sides of the tobacco wars, with health groups cheering and retailers grumbling.The British Medical Association said it was "very pleased" with the announcement, citing research which it said showed that a display ban would play "a key role in discouraging children from smoking and also help smokers quit."On the other hand, industry groups and independent retailers complained it would burden them with the cost of refitting their stores and reduce their already narrow profit margins.And according to media interviews, many people kept skeptical about the real impact the move would have, especially on young smokers.
BEIJING, Jan. 31 (Xinhua) -- Chinese Vice Premier Wang Qishan met in Beijing Monday with a delegation from the Geneva Association (GA), an insurance economics group, headed by chairman Nikolaus Von Bomhard.Wang hoped the GA board would hold a successful board meeting in Beijing, praising the positive role the organization played in promoting reform of the international insurance industry.China's insurance industry was undergoing rapid and profound changes and development, said Wang. He hoped the GA could work with Chinese insurance companies to jointly push forward the global development of the industry.Chinese Vice Premier Wang Qishan (R) meets with Nikolaus Von Bomhard, chairman of the Geneva Association (GA), an insurance economics group, in Beijing, capital of China, Jan. 31, 2011.Von Bomhard pledged the GA's commitment to stepping up exchanges and cooperation with the Chinese insurance sector.The Geneva Association describes itself as an international insurance "think tank" for strategically important insurance and risk management issues. It is the first time that the association has hosted a board meeting in an Asian country.