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U.S. government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalized with COVID-19 because it doesn’t seem to be helping them.Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue. But on Monday, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look did not verify a safety problem but found a low chance that the drug would prove helpful for hospitalized patients.It is a setback for one of the most promising treatment approaches for COVID-19. President Donald Trump received a similar experimental, two-antibody drug from Regeneron Pharmaceuticals Inc. on an emergency basis when he was sickened with the coronavirus earlier this month.In a statement Lilly notes that the government is continuing a separate study testing the antibody drug in mild to moderately ill patients, to try to prevent hospitalization and severe illness. The company also is continuing its own studies testing the drug, which is being developed with the Canadian company AbCellera.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. The experimental drugs are concentrated versions of one or two specific antibodies that worked best against the coronavirus in lab and animal tests.Lilly and Regeneron have asked the U.S. Food and Drug Administration to grant emergency use authorization for their drugs for COVID-19 while late-stage studies continue. Lilly says its request is based on other results suggesting the drug helps patients who are not hospitalized, and that it will continue to seek the FDA’s permission for emergency use.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 1928
Two US Marine aircraft crashed off the coast of Japan, the US Marine Corps announced Wednesday in a statement.It is believed five individuals were on board a KC-130 and two individuals were in a F/A-18, two US defense officials told CNN. At least one Marine had been rescued just before 6 p.m. ET, according to a Marine Corps spokesman."Search and rescue operations continue for US Marine Corps aircraft that were involved in a mishap off of the coast of Japan around 2:00 am Dec. 6," local time, a statement by the US Marine Corps reads.The planes "had launched from Marine Corps Air Station Iwakuni and were conducting regularly scheduled training when the mishap occurred," according to the statement.The crashes happened approximately 200 miles off the coast of Iwakuni, Japan, a US Marine Corps official tells CNN.The primary mission of a KC-130 is airborne refueling. It is not known at this time if the aircraft was refueling at the time of the crash."The circumstances of the mishap are currently under investigation," the statement said.."Japanese search and rescue aircraft immediately responded to aid in recovery," according to the statement.Wednesday's incident comes on the same day that the Marines released a report on a crash in July 2017, also involving a KC-130 variant that killed 15 Marines and one sailor.That KC-130T crash took place in Leflore County, Mississippi, and the "investigation determined that the aircraft's propeller did not receive proper depot-level maintenance during its last overhaul ... in September 2011, which missed corrosion that may have contributed to the propeller blade" coming loose during the flight and going into the aircraft's fuselage, according to a Marine Corps statement on the investigation. 1759
TWIN LAKE, Mich. — After Christy Hester lost her husband, Richard, in January, there was one thing she was having trouble parting with: his glasses. 156
Vaccinating children has become a hot topic in the last decade, as arguments often play out on social media, leaving some parents unsure and doctors scrambling to get them the right information. Not too long ago, all mother Megan Whelan was thinking about was how to vaccinate her children."With all the information that's out there all the celebrities who are you know spreading their stories And of course all the blog posts and things you see on Facebook and all of that," Whelan said. "It can be really overwhelming."She decided to take her doctor's advice, but said it would have been nice to have other options for trusted information."I think to be able to go to one place where you can hear both sides of the story would be really interesting," Whelan said. "And you know, where you could hear from of course doctors other professionals but even just a panel of moms."Researchers wanted to know if providing parents with accurate clinical information about vaccines through a website with access to vaccine experts would impact their attitudes about them. They found out it did.Dr. Matthew Daley, a senior researcher at Kaiser Permanente, paneled a group of soon-to-be parents. His team gave some parents vaccine information from a website, others information from a website, social media, blogs, podcasts and chats, and others standard care. Daley's team found that website and social interaction improved attitudes toward vaccines in parents who were hesitant about them."Specifically their confidence in the benefits of vaccines improved," Dr. Daley said. "And then there are concerns about the risks of vaccines decreased."Dr. Daley hopes this can be a model used nationwide to address parents vaccine concerns."Parents need more information than they're able to get in a brief visit with their child's physician," Dr. Daley said. 1880
UTAH COUNTY, Utah – Most days begin about the same for Jeff Smith. He makes sure to squeeze in time in the home gym and tries to eat healthy. Smith is really like most Americans, except he is completely blind.“It’s called retinitis pigmentosa,” Smith explained.It’s a hereditary disease that slowly stole his sight.“Usually, it starts out in the periphery and slowly works its way in until it’s like you’re looking through a tube,” he said.Smith has had to relearn just about everything in his life“You know, things like brushing your teeth, finding clothes to wear,” Smith said. “I probably don’t match very well here today.”Technology has become like a best friend.“I use technology from the moment I get up from probably the moment I go to sleep,” Smith said.This past election cycle, he tried something for the first time.“Anything new or different to a blind person is scary,” Smith said.He voted entirely on his mobile phone using an app called “Voatz”His country was among several in the country participating in the pilot program. The pilot program was for voters who are either disabled or overseas at the time of the election.“My county has historically been a bit of a mess when it came to elections,” said Utah County clerk Amelia Gardner Powers.Gardner Powers decided to try and clean things up.“We deliver your ballot to you on your phone, you mark your preferences on your phone and then you submit it back to us,” Gardner Powers said. “We actually print off your ballot using a ballot printer and run those through the scanner with all of our other ballots.”She says the response has been phenomenal, especially in a year like 2020“People’s access to the polls has been limited. Just think of all the things that have happened like hurricanes, flooding, wildfires,” Gardner Powers said.And of course, a global pandemic. Those in quarantine or afraid of exposure could vote at home.“Their voter registration went from single digits to high double digits,” said Jonathan Johnson.Johnson knows a thing or two about elections and technology. He ran for governor in the state of Utah and is now the CEO of Overstock.com. Johnson is urging community leaders to give the tech a try so more people can vote.“Once a vote is put into blockchain technology, it doesn’t change. It’s not just one database that can be hacked and changed, it’s put into a kind of distributed database so if one is changed, all the others are not,” Johnson explained.Think of it like multiple virtual safety deposit boxes holding your vote.“This is safe and secure,” Johnson said. “It’s more secure than just showing your license when you show up at a junior high school gymnasium.”For Smith, it means voting without any help.“Well, this is the United States of America,” Smith said. “Voting is a patriotic thing to me. It is a blessing to be able to participate in the political process.”Smith may have lost his sight, but when it now comes to voting? He has gained his independence. 2976