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For the first time in more than a decade, a new treatment to improve brain function for Alzheimer’s disease has been submitted to the Food and Drug Administration (FDA) for review.This was after the drug trial was stopped and then a second look revealed some promising results.The Waterhouse family has seen the impact of Alzheimer’s firsthand.Gina and Steve Waterhouse have been a team most of their lives. They’ve been married for 43 years and ran several businesses together. Then in 2016, things started to change. Gina didn’t notice anything but employees at the family's businesses did.“I wasn't remembering some of the stuff I was supposed to be doing,” said Gina.Gina was diagnosed with early Alzheimer's disease that year.“They said, 'well you can come back in a year. We will check and see how you're doing, or we have a drug trial if you're interested,'” said Gina.Gina and Steve spent the next two and a half years at the Mayo Clinic, where Gina eventually got high doses of the drug aducanumab.Steve started to notice Gina was remembering more things and reported it back to doctors.“He just smiled and said, 'let me tell you what we're seeing. We're seeing cognitive improvement. And it’s the first time in my career.' These doctors said in their career that we've ever seen it,” said Steve.“He was so excited,” said Gina.Then in 2019, the drug trial suddenly ended. Gina says she felt like she’s gone downhill a little since it did.Rebecca Edelmeyer, PhD, with the Alzheimer’s Association, says the trial stopped early based on a futility analysis.“It was a statistical analysis that was done by the Biogen team, predicting that the trial would not actually be successful,” said Edelmeyer.Edelmeyer says then upon a second look at the trial data, they found that those people on the highest dose of the drug were seeing improvement in their brain function. She called it a very important moment for the Alzheimer’s research community.Now, the government will determine whether or not the drug is safe and effective enough to use.Steve mentioned there were some possible side effects like bleeding of the brain, but Gina did not experience any.Meanwhile, Gina can no longer take the drug. She and Steve have decided to retire.“We just decided tomorrow has to come today and we're having a great time. We're loving life,” said Gina.You can learn more about aducanumab here. 2394

For many of us, the word “outbreak” has taken a more personal meaning this year.For the people of Austin, Indiana, it’s not the first time they’ve dealt with an outbreak.“We’re an itty-bitty town, but we got big city problems,” said Austin resident Ethan Howard.By 2015, the opioid crisis had ravaged Howard’s hometown for years. People became hooked on painkillers and often used needles to take them. The same syringes would be passed from person to person.Dr. William Cooke arrived in Austin in 2004. Back then, he was the town’s only doctor. In fact, he was the town’s first doctor in a generation. He says he saw several issues in the southern Indiana community, including people’s health to poverty.As the opioid crisis started to wrap its grip across parts of the country, Dr. Cooke says he started to see another health issue spread in the community, starting around 2010.“What we saw was a really quick in dramatic rise in Hepatitis C around that time,” Dr. Cooke said. “Any community that has a high Hepatitis C rate is at high risk for an HIV outbreak.”By 2015, the opioid crisis had ravaged the city for years.“Opiates were my devil,” Howard recalled.Howard says his mom convinced him one day to go get tested, after he says he had shared a needle with his cousin.His test revealed he was positive for HIV.“I thought I was dead. I thought it was a death sentence,” Howard said.He wasn’t alone with testing positive for HIV in Austin.“In that first year, we had almost 200 cases,” Dr. Cooke said. “It was almost a quarter of the HIV cases in the state and this is a town of 4,200 people.”Austin had become home to one of the largest HIV outbreaks in rural America ever.Dr. Cooke helped convince then-Indiana Gov. Mike Pence to change his stance on needle exchanges.“It took a few months, but eventually, he signed the executive order allowing us to operate syringe service programs here,” Cooke said.That program, access to addiction recovery services and powerful HIV medicine has led to a dramatic drop in new cases.In 2015, Scott County, Indiana had 157 new HIV cases. In 2019, the county had only five, according to the Indiana Department of Health."The medications today are powerful enough and well tolerated enough that you should not spread the disease to anyone else and you should never worry about dying from HIV,” Dr. Cooke said.Dr. Cooke says Austin is still working to overcome some of the social challenges he found when he first arrived in the community in 2004.It’s been five years after the largest HIV outbreak in Indiana history. Like many communities across the world, this one is now dealing with the impacts of COVID-19.Nurse Jessica Howard is a proud native of Austin. She’s seen the challenges her community has faced over the years. She also sees the good in Austin, pointing to a local church pantry providing food and clothes to those in need.Jessica Howard in charge of coronavirus testing at Dr. Cooke’s office. She grew up in Austin and knows many of the patients that come through the door.As of early July, Scott County has not seen a large amount of coronavirus cases like other parts of the country, but the nurse worries about her patients that struggle with addiction who are now in quarantine and could relapse."These are people these are our people and we have to take care of them and protect them,” she said.Austin has come a long way from where it was in 2015, when HIV spread through a large part of the community.Last year, Dr. Cooke was named by American Academy of Family Physicians the AAFP 2019 Family Physician of the Year for his efforts to help stop the 2015 HIV outbreak.As for Howard, he says medication has made it so HIV is no longer detectable in his blood.He now travels as a musician and points to music as a source of strength that helped him through the darkest of times.“I fought and clawed my way out of a dark place,” Howard said.His fighting spirit is one this small Indiana city has used to battle through crisis before.“We’ve been through a healthcare disaster before,” Dr. Cooke said. “And there is a light on at the end of a tunnel.”It’s a mindset Dr. Cooke says we need now, as we all fight this new crisis of a coronavirus pandemic. 4221

First lady Melania Trump said that she has "much more important things" to focus on than the alleged infidelities of her husband, President Donald Trump."It is not concern and focus of mine. I'm a mother and a first lady, and I have much more important things to think about and to do. I know people like to speculate and media like to speculate about our marriage," the intensely private first lady told ABC News in a taped interview last week during her first solo foreign trip.Asked if she's been hurt by the allegations, Trump, after a brief pause, said, "It's not always pleasant, of course, but I know what is right and what is wrong and what is true or not true."Asked by ABC News if they still have a good marriage and if she loves her husband, the first lady replied, "Yes, we are fine." 804

For many 5-year-old kids across the country, kindergarten is an exciting first introduction into the classroom. But this year, schools are grappling with growing COVID-19 cases and declining kindergarten enrollment numbers."In terms of our kinder cohort, we usually have about 23,000 students registered in Miami-Date County schools for kindergarten. Right now, as of this week, we have a total of 14,724 registered already for next year," said administrative director Berena Cabrera, with Miami-Date County Public Schools in Florida.Cabrera says the district is tackling a 40-percent decline in kindergarten enrollment, and other public schools across the country are dealing with a similar situation.At Visalia Unified School District in central California, kindergarten enrollment is down by 15 percent. At Poway Unified School District, near San Diego, they're seeing 5 percent less kindergarten students enrolling. Fulton County Schools in the Atlanta, Georgia area reports 12 percent less students are enrolled in kindergarten for the upcoming school year."Kindergarten is critical. It is the foundation of a successful student. And in Florida, it is mandatory for students to start kindergarten," said Cabrera.While kindergarten isn't mandatory in all states, educators agree it's an important beginning to a student's education. Rising coronavirus cases in communities combined with public schools having to tackle the virus head-on, has prompted some parents to turn to private kindergarten.Primrose Schools, which offers private daycare, preschool and kindergarten at more than 400 locations across the country, says they've seen a massive increase in interest, especially for those parents whose local districts are offering a virtual-only program this fall."Many of the working parents, obviously, they’ve got to have childcare. Where they would have had before and after school care now they're going to need full day. So, what we’ve seen is our schools responding rapidly by many of them opening up classrooms to kindergarten programs," Jo Kirchner, CEO of Primrose Schools, said.Kirchner says some of their locations are adding kindergarten classrooms to accommodate the increased interest. Their schools offer a 1:10 teacher to student ratio, plus heightened sanitation protocols."Even the parents who stay home with their children, who now find themselves virtual versus sending them to school, don’t really have the skill sets to provide the academic learning support the children need,” Kirchner said. “Kindergarteners have a fairly short attention span so distance learning is not the best environment for a kindergartner.”While kindergarten families across the country consider their options, Miami-Dade County Public Schools is converting a lot of their enrollment from paper to digital. Additionally, they're doing a big push on the district's website and social media."We’re hopeful that registration does pick up in the coming weeks. We are rolling out with a major marketing campaign, and we’re trying to let the parents know that there are staff in our schools that are registering," said Cabrera.Cabrera adds, whether kindergarten is in-person or remote learning this fall, she hopes parents will enroll their children for this crucial first start to their academic career. 3309

For years, the incredible discovery of the Titanic's wreckage at the bottom of the ocean in 1985 was thought to have been a purely scientific effort.But that was a ruse.Speaking to CNN on Thursday about now-declassified events, Robert Ballard, who discovered the Titanic, said that the expedition was part of a secret US military mission to recover two sunken nuclear submarines on the bottom of the ocean."They did not want the world to know that, so I had to have a cover story," Ballard said.The true story of what happened now serves as a museum exhibit at The National Geographic Museum in Washington, which is open through the end of the year.Ballard was a commander in the US Navy and a scientist at the Woods Hole Oceanographic Institution. The Navy offered him the funding and opportunity to search for the Titanic, but only if he first explored the USS Thresher and the USS Scorpion, two American nuclear subs that sank in the 1960s."We knew where the subs were," Ballard said. "What they wanted me to do was go back and not have the Russians follow me, because we were interested in the nuclear weapons that were on the Scorpion and also what the nuclear reactors (were) doing to the environment."The search for the Titanic served as a great cover story, and the press was "totally oblivious to what I was doing," he said.When his team finished exploring the Scorpion and Thresher, they had just 12 days left in their trip to search for the Titanic.The famed ship that sank on its maiden voyage was found on the ocean floor at a depth of more than 12,000 feet in the North Atlantic Ocean."When we found the Titanic, we naturally were very excited, because it was a tough job. We got it, scoring the winning goal at the buzzer," Ballard said.The famous discovery set off major press attention, but the expedition's true purpose was kept under wraps. A New York Times story from the days after the discovery features a series of denials from officials about the project.Navy spokesman Capt. Brent Baker said at the time that the project was simply to test if the oceanographic system worked, and a scientist denied a military involvement.''There was nothing classified,'' Dr. Robert Spindel, the head of the Woods Hole Ocean Engineering Department, told the Times.Not so, Ballard admitted, and that wasn't the only one."I cannot talk about my other Navy missions, no," he said. "They have yet to be declassified." 2450