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A third leading candidate COVID-19 vaccine has entered a final stage of human testing in the United States. AstraZeneca announced Monday its potential COVID-19 vaccine has entered final trials in the U.S. to test the effectiveness and safety of the product. The Cambridge, England-based company said the trial will involve up to 30,000 adults from various racial, ethnic and geographic groups. The potential vaccine was invented by the University of Oxford and an associated company, Vaccitech.AstraZeneca said development of the vaccine known as AZD1222 is moving ahead globally with late-stage trials in the U.K., Brazil and South Africa. Further trials are planned in Japan and Russia.“To have just one vaccine enter the final stage of trials eight months after discovering a virus would be a remarkable achievement; to have three at that point with more on the way is extraordinary,” Health and Human Services Secretary Alex Azar said in a statement.Two other vaccine candidates began final testing this summer in tens of thousands of people in the U.S. One was created by the National Institutes of Health and manufactured by Moderna Inc., and the other developed by Pfizer Inc. and Germany’s BioNTech. 1215

A report from the Department of Veterans' Affairs inspector general found that the Washington DC VA Medical Center has for years "suffered a series of systemic and programmatic failures to consistently deliver timely and quality patient care," and heightening the potential for waste, fraud and abuse of government resources.The report released Wednesday found that the main health care facility for veterans in Washington lacked consistently clean areas for medical supplies, had staffing issues across multiple departments and that approximately million in supplies and equipment were purchased over a two-year period without "proper controls to ensure the purchases were necessary and cost-effective."According to the report, VA Secretary David Shulkin said he "does not recall senior leaders' bringing issues at the medical system related to supplies, instruments and equipment to his attention" while he was the undersecretary of health.The VA has been rocked by the IG report and Shulkin's belief that Trump administration political appointees, including a top aide, have been working toward his ouster.The report did not find any patient harm, but VA Inspector General Michael Missal said that was "largely due to the efforts of many dedicated health care providers that overcame service deficiencies to ensure patients received needed care."In the report detailing the troubling conditions at the VA hospital, Missal faults "failed leadership at multiple levels within VA that put patients and assets ... at unnecessary risk." The report follows an interim report released in April 2017, which Missal took the rare step of issuing because he had a "lack of confidence" in the Veterans Health Administration to properly deal with the issues, some of which they had known about for some time.The report made 40 recommendations, all of which the Department of Veterans Affairs said it accepts. "On behalf of the senior leaders at DC VAMC, Veterans Integrated Service Network (VISN) 5 and the Veterans Health Administration (VHA), we concur with OIG's findings and recommendations and provide the attached action plans," the Office of the Undersecretary for Health said in response to the report.The investigation into the Washington DC VA Medical Center, which provides care to almost 100,000 veterans and employs more than 2,000 people, began in March 2017 after a confidential complaint, according to the inspector general's report.The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 2547

A new study suggests misguided antibodies created as a response when someone is infected with the coronavirus could be the cause behind both more severe COVID-19 symptoms and those who report having symptoms for months after initially recovering.Researchers at Yale University found that COVID-19 patients they studied had high levels of antibodies that had turned on them; these wayward antibodies blocked antiviral defenses, wiped out helpful immune cells and attacked the body in several areas including the brain, blood vessels, liver and gastrointestinal tract.“Covid-19 patients make autoantibodies that actually interfere with immune responses against the virus,” Aaron Ring, an immunobiologist at Yale and senior author on the study, told The Guardian.Autoantibodies are antibodies that attack the body’s own proteins by mistake and disrupt their normal functions.“We certainly believe that these autoantibodies are harmful to patients with Covid-19,” said Ring. He added that the harmful effects of these autoantibodies could continue well after the initial infection has been overcome. He said antibodies can last for a long time, and if they are misguided in their attacks, the effects of their attacks on the body could also last a while.The study, which has yet to be peer reviewed and formally published, looked at antibodies from 194 COVID-19 patients and hospital workers with a range of symptoms and severity of symptoms.Other conditions, like lupus, multiple sclerosis and rheumatoid arthritis, are also made worse by the immune system malfunctioning and attacking the body. 1600

A new technology is coming to airports to help with passenger screening from home to plane. Denver International Airport will soon be the first to test Daon’s IdentityX platform. It creates a digital identity for each passenger that can be used at kiosks and e-gates, then help travelers schedule times to go through security and get to terminals.That digital identity, called Glide, will also include biometric data and be used for passengers to show their health status using a badge on their cell phone. Down the road, the platform could also mean touchless payments at stores and restaurants.“So what we're trying to do is allow people before they come to the airport, maybe for the first time or maybe for every time, to really begin to feel confident that they can control the time and space elements of their journey,” said Chris McLaughlin, Chief Operating Officer at Denver International Airport.The same technology can be used to improve safety for the thousands of staff and TSA officers that come and go from the airport every day. 1051

A new report from the CDC and Rhode Island shows COVID-19 rates below one percent in childcare facilities with young children this summer. They also found a low rate of secondary transmission among these facilities, with 15 percent of coronavirus cases resulting in transmission to at least one other person.“The critical thing here is to build the confidence of teachers, the confidence of parents,” said Dr. Robert Redfield, Director of the Centers for Disease Control and Prevention. “This study provides data, that when things are done with vigilance in partnership with the public health community, you can, in fact, in a complex situation like child care ... you can reopen child care" and have low rates of secondary transmission. The study tracked coronavirus cases at childcare facilities in Rhode Island this summer. On June 1, the state was seeing a decline in coronavirus cases and hospitalizations, and allowed childcare programs to re-open after a 3-month closure.In order to reopen, the facility had to submit a plan to the state for approval that included reduced enrollment, a cohort of no more than 20 people including kids and staff, universal use of masks for adults, and daily symptom screening of adults and kids.Roughly 75 percent of licensed center and home-based childcare facilities were approved to reopen, caring for 18,945 children.Between June 1 and July 31, there were 101 possible child care-associated COVID-19 cases identified at the facility level; among those, 49 were excluded because they had a negative COVID-19 test.Of the remaining 52 confirmed and probable cases, 30 were children; that is roughly .16 percent of the 18,945 children in childcare in Rhode Island this summer. There were 20 teachers and 2 parents who are among the confirmed or probable cases.Cases were confirmed an average of two days after specimen collection.Contact tracing led to the quarantine of 687 children and 166 staff members; that’s roughly 3.6 percent of the total children in Rhode Island care facilities this summer being impacted by quarantine efforts.The cases happened at 29 of the 666 childcare facilities, in 20 of the facilities, there was a single coronavirus case and no transmission. Five of the 29 programs, 15 percent, had two to five cases.The remaining four coronavirus cases may or may not have had secondary transmission. Health officials state those facilities were breaking protocol by moving members of a cohort around to other classrooms, delayed reporting of symptoms, etc. that made it difficult to track.The CDC warns these results were only possible because of decreasing COVID-19 rates in the state, and the community effort to slow the spread of coronavirus. This includes wearing masks and practicing social distancing when around other people.“I understand masks can be uncomfortable to wear and hard to remember to bring when you go out,” Dr. Redfield said. “Schools are not islands in and of themselves, they are connected to the communities around them.”The study says maintaining stable staffing was one of the most difficult things; needing to cover teacher breaks, vacations, etc. while still maintaining the smaller cohort sizes.They recommend additional funding to continue with the smaller class sizes. 3271