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Businessman Dai Yujian, 37, returned to his hometown in Daizhuang village, Lankao county, in 2014"to help my villagers in need", he said.

Breast cancer affects 1 in 8 women globally. It is the second-leading cause of death from cancer in women, surpassed only by lung cancer in its deadliness and overall prevalence.

But Amazon is struggling to contend with local leaders such as Alibaba Group Holding Ltd, JD and NetEase Kaola, which have been ramping up their efforts in cross-border shopping.

Brian Charlson, with the American Council of the Blind, has been involved in wayfinding for over 30 years and has seen a number of airports and train stations try different technological approaches to make their spaces easier to navigate for the visually impaired. The NavCog app, he said, is a useful mashup of systems he's seen over the years.

Businesses from around the world in such sectors as agricultural products are also feeling the pain.