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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.
SAN FRANCISCO, Dec. 2 (Xinhua) -- Only two weeks after its shipment, Amazon's Kindle Fire has already shown the momentum to grab the second place in global tablet computer market, research firm IHS predicted on Friday.Amazon is expected to ship 3.9 million Kindle Fire tablets during the last three months of 2011, the first quarter the product goes on sale, according to preliminary projection from IHS.The number will give Amazon a 13.8-percent share of global tablet market in the fourth quarter, surpassing the 4.8 percent held by No. 3 player Samsung, and second only to Apple's commanding 65.6 percent market share."Nearly two years after Apple Inc. rolled out the iPad, a competitor has finally developed an alternative which looks like it might have enough of Apple's secret sauce to succeed," Rhoda Alexander, senior manager of tablet and monitor research for IHS, said in a statement."Initial market response strongly suggests that Amazon, with the Kindle Fire, has found the right combination of savvy pricing, astute marketing, accessible content and an appropriate business model, positioning the Kindle Fire to appeal to a brand-new set of media tablet buyers," she added.IHS analysts noted that with a price tag of 199 U.S. dollars, the Kindle Fire has set a new bar for pricing, bringing the tablet within reach of a larger portion of the buying public.IHS expects Kindle Fire's rapid ascent to help fuel the expansion of the entire tablet market, now predicting that 64.7 million tablets will be shipped in 2011, higher than its previous forecast of 60 million issued in August.The total tablet shipment number this year will represent a 273- percent growth from 17.4 million units in 2010, said IHS, which has also increased its longer-term projection of global tablet shipment in 2015 to 287.2 million units.

CANNES, France, Nov. 3 (Xinhua) -- Chinese President Hu Jintao on Thursday urged the world's major economies to work together to promote growth and financial stability."It is imperative that we stand on a higher plane, transcend differences on specific issues, move beyond short-term considerations, and jointly seek ways to overcome the crisis and sustain development," Hu told the Group of 20 (G20) summit here."At this critical moment, the G20 must work to address the key problems, boost market confidence, defuse risks and meet challenges and promote global economic growth and financial stability," said Hu.As the premier forum for international economic cooperation, the G20 must continue to demonstrate the spirit of standing together in times of adversity and pursuing win-win cooperation, he said.The Chinese president said "the current world economic situation deserves our high attention," cautioning the global recovery is fraught with instability and uncertainty and faces growing risks and challenges.Some major economies are experiencing economic slowdown and some countries are facing acute sovereign debt problems, said Hu.He also cited volatility in the international financial markets, and high inflationary pressure in emerging markets.Hu put forward a five-point proposal on what G20 nations need to do to tide over the crisis.First, the countries should ensure growth while paying attention to balance. Given the serious risks facing the global economy and continued market volatility, ensuring growth and promoting stability should be the top priority, he said."We should introduce new and strong measures to ensure that fiscal and monetary policies are fully implemented and that funding is channeled into the real economy to boost production and employment."Second, the G20 nations should strengthen unity and send a strong signal to the world as there is widespread panic and acute lack of confidence in the markets, said Hu.He urged G20 members to strengthen consultation and coordination, tackle sovereign debt risks, regulate cross-border capital flow, put the fluctuation of commodity prices under control, mitigate global inflationary pressure and make sure that the economic policies pursued by various countries do not offset each other.Third, global economic governance should be improved through reform, Hu said.The international financial crisis has highlighted the deficiencies in the global economic governance system, said Hu."Major efforts should be made to reform and improve the international monetary system, international trading system and commodity pricing mechanism," said the Chinese president.
SAN FRANCISCO, Nov. 11 (Xinhua) -- Logitech, a provider of personal peripherals for computers and other digital platforms, said its production of Google TV was a "big mistake," giving a major blow to Google's aspiration to change the traditional TV experience, U.S. media reported on Friday.According to technology news site The Verge, at a recent analyst and investor meeting, Logitech chief executive officer Guerrino De Luca said the launch of Logitech Revue (with Google TV set-top box) last year was "a mistake of implementation of a gigantic nature."The project cost the company more than 100 million U.S. dollars in operating profit.He said the company had "brought closure to the Logitech Revue saga" and has "no plans to introduce another box to replace Revue" after the inventory runs out this quarter.The CEO also predicted that Google TV will have a chance sometime in the future, but it would be a "grandchild of Google TV " that would do it. Logitech has no plans to help make that happen.Launched during the holiday shopping season last year, the Logitech Revue with Google TV system was criticized for being pricey and unpolished although it gives consumers a streamlined experience of traditional TV content and online media. In August, Logitech slashed the price from 249 dollars to 99 dollars.Last month, Google introduced a redesigned Google TV after sales of the first version did not meet expectations.In April, Logitech reported that Revue with Google TV set-top box and related gear only brought five million dollars in sales during the first quarter of this year, 72 percent less than the company had expected.However, support from some leading TV manufacturers may still help Google fulfill its TV plan. A Bloomberg report said Friday that Google and LG Electronics, world's second-largest TV manufacturer, may unveil a television using the search giant's software at the upcoming Consumer Electronics Show in Las Vegas.Samsung, world's largest TV manufacturer, said in February that it was in discussions with Google to develop a TV product.
PARIS, Oct. 1 (Xinhua) -- People come to the French capital will be able to enjoy a new public service by leasing electric cars in the urban region from Sunday.This car-sharing system is aimed to reduce the number of private cars as well as restrain pollution, according to the Paris municipal government.The plan, dubbed "the Autolib" system, is similar to already functioning "velib system" which is a large-scale public bicycle sharing system in Paris launched in 2007.The first experimental stage of the Autolib project is said to last two month with 66 cars at 33 stations around the city.Costumers can pay between 5 euros and 7 euros (6.7-9.4 U.S. dollars) for every half-hour use or register for a yearly, weekly or 24-hour package with different cost and necessary identity cards, driving licences and an uncashed deposit.Once fully charged, the four-seated "Bluecar" can reach a top speed of 130 km an hour and has a range of 250 km with a single charge.In order to encourage short journey rather than long trip around the capital, Paris administration wants to expand the system to a 250-car team by this December, and then to 2,000 by next summer.
来源:资阳报