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WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."
BEIJING, Aug. 22 (Xinhuanet) -- Researchers have discovered how a human egg captures an incoming sperm for fertilization, paving the way to help couples suffering from infertility, according to media reports on Monday.An international team of researchers found that a sugar chain known as the sialyl-lewis-x sequence (SLeX) makes the outer coat of the egg “sticky,” which has proven to be helpful in binding the egg and the sperm.As a result, this observation has filled in a huge gap in the understanding of fertility and provides hope for ultimately helping couples who currently cannot conceive.Scientists and doctors know that a sperm identifies an egg when proteins on the head of the sperm match and bind to a series of specific sugars in the egg’s outer coating. With a successful match of proteins, the outside surfaces of the sperm and egg then bind together before merging, which is then followed by delivery of sperm’s DNA into egg.To identify this molecules, the researchers used ultra-sensitive mass-spectrometric imaging technology to observe and identify which molecules are most likely to be key in the binding process.They experimented with a range of synthesised sugars in the laboratory and found that it is SLeX that specifically binds sperm to an egg.According to the World Health Organisation, infertility affects about 15 percent of reproductive-aged couples around the world and almost one in every seven couples in Britain has problems conceiving a child for various reasons.

WASHINGTON, Aug. 16 (Xinhua) -- The White House announced Tuesday that the U.S. Departments of Agriculture, Energy and Navy will invest up to 510 million U.S. dollars in partnership with the private sector to facilitate the country's biofuel industry development."Biofuels are an important part of reducing America's dependence on foreign oil and creating jobs here at home," U.S. President Barack Obama said in a White House statement.The initiative is a response to a directive from Obama issued in March as part of the Blueprint for A Secure Energy Future, the administration's framework for reducing dependence on foreign oil."But supporting biofuels cannot be the role of government alone. That's why we're partnering with the private sector to speed development of next-generation biofuels that will help us continue to take steps towards energy independence and strengthen communities across our country," Obama added.The joint plan calls for the three departments to invest up to 510 million dollars in the next three years, which will require substantial cost share from private industry, in a bid to reduce U. S. reliance on foreign oil and create jobs at home."By building a national biofuels industry, we are creating construction jobs, refinery jobs and economic opportunity in rural communities throughout the country," said U.S. Agriculture Secretary Tom Vilsack.White House figures revealed that the world's largest economy spends more than 300 billion dollars on imported crude oil every year.With a slackening economic recovery and the government's approval rate at a record low level, the Obama administration is rolling out a string of measures in recent days to accelerate economic growth and job creation.
Beijing, Sept. 13 (Xinhuanet) -- A fear of taking antidepressants often results in people's reluctance of going to see the doctor when they are suffering from depression, a study find.The finding was published Monday in the U.S. journal Annals of Family Medicine.The researchers from the University of California investigated 1,054 adults on why they wouldn't tell the doctors about their depression symptoms, as well as any possible mental disorder.Among the participants, 43 percent admitted that they had been reluctant to tell the doctor about their depression symptoms.Their top concern was the possibility of being prescribed an antidepressant -- a worry voiced by 23 percent of the whole study group.Another 16 percent thought dealing with "emotional issues" is not the doctor's job. And a similar percentage worried that the diagnosis of depression may leave a negative record on their medical records.The study would be helpful for looking into the reasons that patients harbor the attitudes that they do, said Dr. Hellerstein of the New York State Psychiatric Institute and Columbia University Medical Center in New York.
HELSINKI, July 4 (Xinhua) -- A new Finnish research shows that sleeplessness may be hereditary, and insomniacs are more likely to die earlier than people with healthy sleep patterns.The research is the first to link insomnia with mortality risk, Finnish media reported on Monday.The research is conducted by the Institute of Occupational Health in collaboration with the University of Helsinki and the Finnish National Institute for Health and WelfareIn a large-scale twin study, the Finnish researchers followed the health status of 12,500 adult twin pairs during the years from 1990 to 2009. Twenty percent of the participants were suffering from sleeplessness symptoms, including difficulty in initiating sleep, nocturnal awakening and non-restorative sleep.The study found out that compared with unidentical twins, identical twins were more likely to suffer from similar insomnia symptoms. This finding indicates that genetic factors play a role in the formation of insomnia.Moreover, the participants were divided into three groups, according to their sleep qualities. Out of the participants, 48 percent were good sleepers, 40 percent average sleepers and 12 percent poor sleepers. The search result shows that insomnia-related symptoms may increase mortality risk.In addition, compared with good sleepers, 7 percent of the women and 22 percent of the men who were average sleepers were more likely to die earlier; and poor sleepers were 1.5 times more likely to die earlier.According to the researchers, sleeplessness is a common health problem among working-age cohort. Chronic sleeplessness raises the risk of many illnesses and accidents, and thus weakens people's quality of life and ability to operate properly.The experts suggest that insomniacs should seek medical treatment in time, and chronic insomnia patients should be better treated with non-drug therapy.
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