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(KGTV) -- Many scientists and doctors are cautiously optimistic about taking a step forward in the fight against COVID-19 after encouraging news from Pfizer Monday.Pfizer announced that early data revealed its vaccine was more than 90 percent effective in protecting trial participants against the coronavirus.The U.S. Federal Food and Drug Admiration still needs to review the drug for safety and efficacy, and Pfizer plans to seek an Emergency Use Authorization this month, but regardless some see this as a good sign for other vaccine trials.“I think this is frankly the break we’ve all been waiting for, and I hope we have many others to follow,” said Dr. Susan Little, a UC San Diego Professor of Medicine.UCSD is participating in Phase 3 clinical trials for Moderna, AstraZeneca, and Janssen vaccines.Little leads the AstraZeneca and Janssen trials, which resumed locally last week.“I think what this means for all of the trials that are available at this stage, this is incredibly good news,” she said. “So far, they all use the same approach to vaccine development; they are all targeting the same protein, the spike protein, on the coronavirus.”She expects similar results to come from Moderna’s early data sometime this year.“The Pfizer and the Moderna both use the same vaccine platform, the same structure for their vaccine construct, so there’s every reason to be very optimistic the Moderna study might show similar results,” she said. “While the AstraZeneca and the Janssen use a different vaccine construct, they both are targeting the same protein.”If Pfizer’s vaccine is approved, it could be given to healthcare workers and high-risk populations in just months, and the general population in 2021, according to Pfizer.Pfizer said it expects to produce 50 million vaccine doses globally in 2020 and up to 1.3 billion in 2021.Pfizer’s CEO, Albert Bourla, said he expects the vaccine to be free of charge for Americans. 1943

(KGTV) - Police say they've located the two young boys who went missing late Monday night from their home in Escondido. Both boys were found safe in Oceanside by their uncle, according to authorities. Police said 9-year-old Zackariah Valdez and 11-year-old Daniel Cisneros went missing from their home on the 1500 block of W. Valley Parkway at 10 p.m. Monday, prompting an hours-long search. Throughout the day, the two boys were spotted in several locations before their uncle found them later in the afternoon. The children's mother spoke after the two young boys were located. Viviana Valdez said there was a woman who helped take care of her kids after they went missing. “There was a lady who sheltered my kids for a little bit and fed them and again I don’t know who you are, but I want to say thank you. Thank you for, you know, taking them out of the cold and feeding them,” said Valdez. 938

(KGTV/WXYZ) - Less than two months after a report said Toys 'R' Us would close many of its U.S. stores, a new report said the toy store is considering closing all stores. 178

(KGTV) —  Crews watching a tractor-trailer driver navigate a curve on State Route 175 saw the end result coming a mile away.Video shows a big rig try to make it around a one lane section of SR-175 between Hopland, Calif., and Lakeport. As crews looked on, they knew it would be difficult."Oh he's in it to win it," one person is heard saying, before the truck begins to fall."There he goes!" another yells.As the truck slowly passed the spot a retaining wall was being built, its back wheel began to cross over the embankment's edge. The weigh of the truck's load pulled the truck over the embankment.Caltrans District 1 said multiple signs warning truck drivers of the truck length restriction (39 feet in total length) have been posted but were clearly ignored."Sometimes they simply get stuck, but others end up going over the embankment. This driver was not injured, but it must have been the ride of his life!" Caltrans wrote. 964

...@CBSNews #EXCLUSIVE CBS News has learned that #police have a person of interest or persons of interest in connection with the #explosion that rocked #Nashville on #ChristmasDay.— Jeff Pegues (@jeffpeguescbs) December 26, 2020 242