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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A grief-stricken Pittsburgh community will have another day of funerals for victims of a synagogue shooting -- even as it struggles to comfort those affected by the massacre.In yet?another day?of anguish for the close-knit community, mourners will gather Wednesday to bury some of the 11 people killed when a gunman stormed the Tree of Life Synagogue on Saturday.Crowds packed funerals Tuesday, with long lines snaking through streets and busloads of people coming from synagogues nationwide. Pedestrians quietly watched as motorcades and hearses passed by, followed on foot by mourners dressed in black . Others held hands and wept.At least three people have been laid to rest in public funerals this week: Brothers David and Cecil Rosenthal, and Dr. Jerry Rabinowitz. Additional funerals are planned Wednesday and Thursday.Those killed were between ages 54 to 97. 898

A man berated employees and customers for speaking Spanish in a New York restaurant, describing them as undocumented and threatening to call immigration officials in a rant captured on video.The incident happened Tuesday at a Fresh Kitchen in Manhattan, according to Edward Suazo, who posted a video of the encounter on Facebook, saying his wife and her friend were the target of the man's anger.The video starts with a man in a white collared shirt confronting employees and customers in the restaurant. 512

A federal judge has sentenced a Louisiana man to 25 years in prison for setting fires at three churches in the state in 2019.Earlier this year, Holden Matthews admitted that, between March 26 and April 4, 2019, he intentionally set fire to three churches in with predominantly Black congregations near Opelousas, Louisiana — Greater Union, Mt. Pleasant and St. Mary Baptist Churches — in an effort to raise his profile as a "Black Metal" musician by copying similar crimes committed in Norway in the 1990s.On Tuesday, Matthews was sentenced to 15 years in prison for intentional damage to religious property. He was then sentenced to 10 years in prison for a charge of using fire to commit a felony. Matthews did get 18 months credit for time already has served.The judge also asked the Bureau of Prisons to ensure he is placed in a facility near his family and that he receives substance abuse counseling and mental health treatment.Matthews was also ordered to pay restitution of 0,246 to St. Mary, 0,213.30 to Greater Union, and .1 million to Mt. Pleasant."These churches trace their origins to the post-Civil War Reconstruction period and, for generations, were a place for predominantly African American Christians to gather, pray, worship, and celebrate their faith," Assistant Attorney General Eric Dreiband said in a statement. "The churches survived for nearly 150 years but did not survive this defendant's warped act of hatred. I extend my sympathy to the victims of this defendant's arson spree, the congregants of St. Mary Baptist Church, Greater Union Baptist Church, and Mt. Pleasant Baptist Church. The Justice Department will continue vigorously to protect their right to worship and live in peace. The Justice Department stands against these acts of hate and the sentence handed down today reflects that. We will continue to protect the civil right of Americans to freedom of worship without fear of persecution.""Hate is not a Louisiana value, and decimating three historically African American churches is beyond disturbing," Louisiana Gov. John Bel Edwards said in a statement. "The same would be true of any place of worship. What Holden Matthews confessed to doing has deeply impacted many lives and threatened the sense of security of members of St. Mary Baptist Church, Greater Union Baptist Church and Mount Pleasant Baptist Church. I pray he truly understands the depth of the pain he has caused. We are all inspired by the continued strength and resilience of the pastors, congregations and community that pulled together after such terrible losses. Everyone involved in assisting in this case is to be commended for their work and commitment to seeing justice served."This story was originally published by KATC in Lafayette, Lousiana. 2780

A fist fight during rush hour at a busy Omaha intersection was caught on cell phone video by another driver. The road rage footage shows two drivers blocking traffic to fight. The incident happened around 4 p.m. Tuesday, but it's unclear what events led up to the fight. The video shows the two men outside of their cars and exchanging blows before the men went into their separate vehicles and drove away.   441

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