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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) -- San Diego County is praising local businesses that are stepping up to the plate during these challenging times.A transportation company out of Oceanside called FACT, or "Full Access Coordinated Transportation," is offering free rides for seniors, the disabled or veterans who may need it for essential needs. That includes needs like doctor's appointments or rides to the grocery store.It is on a first come, first serve basis all across San Diego County.The free ride service runs through April 15th, Monday through Friday, 8 a.m. to 3 p.m.FACT is encouraging anyone who is interested to call ahead at (888) 924 -3228. 647

SAN DIEGO (KGTV) -- San Diego Police are searching for an at-risk missing man who disappeared from downtown Saturday morning. According to police, 57-year-old William Groves was last seen at the corner of 7th Avenue and A street around 10:25 a.m. Saturday. Groves suffers from seizures and has short-term memory loss due to a traumatic brain injury. Police say Groves is also a dependent adult with no money or medication and is visiting San Diego from Hawaii with his mother. According to police, Groves is known to be friendly and talkative. He is described as five feet, five inches tall with brown eyes, gray and black hair and light skin. Groves was last seen wearing a yellow t-shirt with checkered shorts and a black eye patch. Anyone with information on his whereabouts is asked to call San Diego Police at 619-531-2000. 837

SAN DIEGO (KGTV) - San Diego Police identified Monday the man shot and killed in the Shelltown neighborhood. Ricardo Moran, 49, was identified as one of two men who was shot on S. 42nd Street Saturday at 1:35 a.m. Officers received multiple 911 calls about gunshots. When they reached the scene, they found Moran and an unidentified 56-year-old man suffering from injuries. Witnesses heard a vehicle speeding away following the gunshots but were not able to provide a description. Moran died at the hospital. The second victim is expected to survive, police said. There was no word on a possible motive for the shootings.Anyone with information is asked to call the SDPD Homicide Unit at 619-531-2293 or Crime Stoppers at 888-580-8477. 743

SAN DIEGO (KGTV) — San Diegans get a sugary start to the week as the next "national holiday" sets its sights on sweets.National Dessert Day falls on Oct. 14, and what better way to start the week than by satisfying your sweet tooth. The unofficial holiday's origins remain unclear, but honestly that's the last thing on our minds when eating cake, right?So to aid your search for sweets, we've compiled five local spots where you can satisfy your obligation to celebrate and enjoy a delicious treat.Extraordinary Desserts (Various locations): There's a reason Food Network has featured Extraordinary Desserts. If you're stopping in, make sure to try out the shop's danishes or a slice of loaf chocolate cake.SomiSomi (4640 Convoy Street): Check out Convoy Street's SomiSomi for Korean-style soft serve in a delicious fish-shaped pastry bun, called "Taiyaki." Be sure to top it off with sprinkles, graham cracker, or Fruity Pebbles.85C Bakery Café (Various locations): 85C Bakery Cafe has a lot to offer, from cakes to cream puffs to breads. Their cream puffs are packed with creamy frosting and their egg tart is a delicious custard-filled, flaky pastry treat.Edelweiss Bakery (Various locations): Edelweiss Bakery's mouthwatering treats include a German apple cake, delicious fruit tarts, a variety of cookies, and savory cakes. Sweet Revenge Bakery (3319 Palm Avenue): Whether you're craving a cupcake or full cake, Sweet Revenge has your treat. Their Tres Leches parfaits are simply delicious. 1505

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