宜宾内双做双眼皮(宜宾割双眼皮的最好医院) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- California has some of the most expensive gas in the entire country, and a new study by GasBuddy also claims the Golden State also has some of the most aggressive drivers.According to the study, California ranks number one with most aggressive drivers followed by Connecticut and Georgia.The study claims those aggressive habits are also costing Californians cold hard cash. GasBuddy says aggressive driving habits costs an additional 7 per year in fuel.The habits include hard braking, speeding and rapid acceleration.Further finding indicate that the more heavily populated the city, the more motorists drive aggressively.Check out the chart below:  687

SAN DIEGO (KGTV) -- Caltrans is warning drivers about a series of SR-163 closures throughout the week. According to the agency, all lanes of north and southbound SR-163 between I-8 and Genesee Avenue for three to six nights. The highway will be closed so crews can remove falsework from the bridge on the SR-163 Friars Road overcrossing. The southbound closures will begin at 11 p.m. with the northbound closures starting at 11:30 p.m. All lanes will reopen at 5 a.m. The list below shows which lanes will be closed on certain nights: Sunday: All southbound lanes, the northbound far right collector lane and the right main lane (slow lane).Monday: No full freeway closure. Only the northbound and southbound right main lanes.Tuesday: All southbound lanes, and the northbound left lane (fast lane).Wednesday: All northbound lanes, and the southbound left lane.Thursday: No full freeway closures. Only the northbound right lane.Friday/Saturday: No freeway work scheduledSunday, March 10: All northbound lanes. During the closures, drivers on the northbound SR-163 will be rerouted to eastbound I-8 to northbound I-805 to the merge at northbound SR-163.Southbound motorists will be rerouted to southbound I-805 to westbound I-8 to the southbound SR-163 connector ramp. 1274

SAN DIEGO (KGTV) — Beautiful sunsets may be considered a common occurrence in San Diego but that doesn't make them any less special.While pretty much any spot in San Diego can be considered "the best place to see sunsets," there are some areas that capture the scene better.And yes, many of them are at the beach.RELATED: San Diego's?most picturesque spotsBut that's not to say there aren't great places elsewhere! So if you're ready to grab your camera or just observe with your eyes, here's where to enjoy a breath-taking sunset around the county:Sunset CliffsIt's in the name. Sunset Cliffs gives photographers and anyone peering out to sea nearly 180-degrees of sky meeting water to gaze at. And during a sunset, that can create some amazing viewings as colors are reflected off the waves.Balboa ParkAs San Diego's crown jewel, Balboa Park lends itself to beautiful scenes museums and landscaping with the city in the background. Drop in a sunset and those scenes seem to transform once your eyes hit the horizon.Lake CuyamacaThe Lake Cuyamaca area brings San Diego's routinely dry, East County landscape together with the calmness of the lake. Sunsets are reflected beautifully off the lake, while the dry brush and mountains on the horizon can split through, creating some stunning imagery.Temecula wine countryUp north, San Diego County's wine region creates a mesmerizing foreground to sunsets. Between the vines curling up and over one another, rays of sunlight break through.Oceanside HarborThere nothing quite like a shot of the sun peering over masts and sails from boats bundled together in a harbor. Though there may not be a lot of reflection of the water, there's plenty to stand in awe and observe. 1733

SAN DIEGO (KGTV) -- Covid Clinic’s debut in San Diego County was a little rocky in April when it was shut down by Dr. Wilma Wooten, the county’s public health officer.Fast forward to today, the operation seems to be running smoothly in both La Mesa and Downtown San Diego.“Since we were one of the first to open in San Diego County, there were some things that were brought to our attention that the county wanted,” said Covid Clinic CEO, Matt Collins. “So once we met each of the items that they were requesting, we’ve been able to continue testing without any issues.”Wooten sent a letter to Covid Clinic stating that the first site at MiraCosta College in Cardiff needed to shut down because the proper credentials to operate were not provided to the county. Test results also were not immediately reported to the county.Collins said the clinic now reports results to the county every day.He said, on average, about 100 to 150 people are tested at the downtown location, while about 350 to 400 are tested in La Mesa.While many testing sites are now limiting COVID-19 tests to those who have symptoms or fall in the high-risk category, Collins said anyone could schedule an appointment online to be tested at Covid Clinic.Across the country, people have also reported significant delays in test results. Covid Clinic offers three different tests, and Collins said they guarantee quick results.“We understand how important it is to get a result quickly,” said Collins.The antibody and antigen tests come with rapid results in just 60 minutes for 0.The nasal swabs require lab testing, but results can still be provided within the same day, the next day, or two days, however, it is a bit pricier.“The price varies from 375 dollars for a guaranteed two-day turnaround to 425 dollars for same-day turnaround. We’re seeing a lot of demand for that test because people need to travel,” he explains.Collins said the clinic has partnered with a lab in Orange County to deliver results without delays.“We’re going to continue to strive to make testing accessible to San Diegans and always provide the most accurate tests,” he said.In addition to San Diego County, Covid Clinic has drive-thru testing sites in Westminster, Ventura, Norco, and Temecula. Visit https://covidclinic.org/ for more information. 2309

来源：资阳报