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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - It's Signing Day for Lincoln High School seniors.In a first-ever ceremony for the school, college-bound seniors were honored for their hard work and accomplishments on campus Tuesday."It is to inspire underclassmen to aspire towards greatness like their senior counterparts," ASB advisor Malykke Bacon said in an email. "This ceremony is to celebrate these seniors and their accomplishments."RELATED: High Tech Middle student award Navy child of the yearPrincipal Jose Sotoramos took the stage and congratulated seniors before several waves of students stepped on stage and signed their letters of acceptance.Students like Jorge de la Cruz and Jhaunee Diggs plan to stay in-state. Cruz is heading to San Francisco State and become a politician one day. Diggs wants to return to San Diego after attending UC Davis to be a future pediatrician."We have many students doing the right thing every day. This ceremony gives them the opportunity to receive some shine," Bacon added. 1026

SAN DIEGO (KGTV) -- Mixed Martial Arts fighter, Dean "The Boogeyman" Lister is asking the public to help him find a man he found inside his apartment. Lister, a Jiu Jitsu champion, has taken down opponents around the world - but he never expected a fight in his home. "I thought somebody was working in the apartment," he said, describing the man as covered in tattoos and wearing only a pair of boxers.Lister said the man wasn't making any sense, and soon Lister started to record him. In the video the man is heard saying that he went into the apartment because he thought it was a church. When the man realized that he was being record, Lister said he reached for a hammer - a moment that can be seen just before the video ends. Lister is a gun owner, and said he reached for his weapon when the stranger threatened him. At that point, the man got scared and Lister let him escape out the same window he broke in through. When police arrived, the man was gone. "I'm not trying to sound like any kind of saint," Lister said. "But whatever kind of money I lost, maybe it's not worth someone dying."Lister posted the video on Youtube and shared it with 10News in hopes that someone would recognize the intruder. "Hopefully he turns his life around," Lister said.   1327

SAN DIEGO (KGTV) - It’s no surprise to those of us who live in San Diego: America’s Finest City is the finest city for recreation. San Diego was the best in the nation in categories like bike rental facilities per capita (1st), parkland as a percentage of city area (7th), music venues per capita (17th), and percent of population with walkable park access (33rd), according to the Wallet Hub study. "Though it's not among the most affordable cities, San Diego is this year's best city for recreation as it offers plenty of choices in terms of parks, tourist attractions and public beaches,” said Jill Gonzalez, Consumer Finance Analyst. “Other things that make San Diego a good destination are its food festivals, recreational centers, cuisine and wine tours." Other top cities included Las Vegas, Orlando, Honolulu, and Tampa. RELATED: Where to go camping in San Diego County / San Diego County park rangers recommend these trails in 2019 / Set sail in San Diego: 6 booze cruises you'll want to tryDespite its proximity to San Diego, Chula Vista was number 96 of the list of 100 cities, earning the lowest score for entertainment and recreational facilities. 1169

SAN DIEGO (KGTV) -- It's no secret that San Diego has a great food scene, but America's Finest City also has some great dessert spots to explore. Whether you want to sit and relax in a quaint shop or take a photo of an Instagram-worthy dessert, these are some of the best places to check out in the city, according to Yelp reviewers. Check out the full list below:  388

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