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SAN DIEGO (KGTV) -- We’ve known for a while that COVID-19 hits people over 65 especially hard, but a study published Wednesday from researchers in San Diego offers new insight into why that happens.The numbers are staggering: if you’re 65 or older, your risk of winding up in the hospital from COVID-19 is five to 11 times higher than someone under 30. Your risk of death is at least 90 times higher, according to data from the Centers for Disease Control and Prevention.Researchers at the La Jolla Institute for Immunology say the reason why older people fare so much worse appears to be from a lack of T-cells, a type of white blood cell that can decline with age.“Some viruses get controlled by one part of the immune system. Some viruses get controlled by another. In this case it seems that T-cells really do a lot of the work,” said Dr. Shane Crotty, one of the authors of the study published Wednesday in the journal Cell.Dr. Crotty and his colleagues looked at 50 people infected with the virus, and they measured the three elements of the adaptive immune system in detail: antibodies, helper T-cells and killer T-cells.Then they compared the measurements to how people fared against the virus. Some patients in the study group had severe cases, others had mild infections.The researchers found that people with all three branches of the adaptive immune system tended to fully recover. People with severe cases of the virus often lacked one or more of the immune branches, and it was particularly evident in older people.“Our data indicated that of the older individuals, it was particularly the ones that had fewer T-cells to start that look like they really struggled to control this virus,” Dr. Crotty said.As we age, we have fewer T-cells to send after invading pathogens. “That collection of T-cells gets smaller. So it’s harder to recognize a new virus,” Crotty said.Among the 748 deaths in San Diego County reported as of Wednesday, 87% were people aged 60 and older.The findings from LJI may have implications in the search for a vaccine against COVID-19. The data suggests that vaccine-makers may want to target a drug that elicits all three branches of the immune response, Dr. Crotty said. Some vaccine approaches, such as inactivated virus vaccines, only elicit two of three branches, not killer T-cells. However, Crotty said it was too soon to rule any candidates. Two strong branches produced by a vaccine could potentially cover for the lack of a third, he said.Crotty said the findings could help vaccine-makers interpret results from the clinical trials and find the right dosing.“Is a given vaccine a good vaccine, and you just need a booster immunization?” he said. “Does it work well in one population but it doesn’t help in the elderly because it doesn’t generate a T-cell response, for example? Those are the scenarios when this type of knowledge will come into play.” 2906

SAN DIEGO (KGTV) - Whether you're into cars, fashion, history, or current events, you could find it in a magazine at Paras News. Now the beloved North Park newsstand is closing down after 70 years."For a lot of people, they're here every day. It's their mainstay," said Ken Gabbara, owner of Paras News for the last 11 years. Health concerns are just one of the reasons he's letting the iconic shop go. RELATED: Several popular San Diego restaurants to close after CEO accused in 0 million fraud scheme"The Internet has worn us down because they're bigger and stronger than us. You can't compete with something they give away for free for the most part," said Gabbara.At one time, they sold over 4,000 types of magazines, but with less published nowadays, that number dropped to 2,500.Longtime customers are sad to see the neighborhood establishment go. "It's going to be missed, it's really going to be missed," said Sharon Maynard, a customer of 35 years.Maynard fell in love with the literary and poetry magazines. "Now they just go online, but for me, there's nothing better than having it in your hand in print," said Maynard.Also sad to see the newsstand go is manager Kent Snyder, who's worked at Paras for 33 years. RELATED: Restaurant closures highlight industry struggles in San Diego"We made an effort to bring stuff into the store that other places don't carry, when they asked for it I ordered it," Snyder.Employees invite the community to buy one more magazine, so they have something of Paras News to hold onto. "We're one of a kind," said Gabbara. Paras News will remain open until the end of December. 1630

SAN DIEGO (KGTV) — Visitors are more than happy to rave about San Diego, according to a new travel survey.San Diego was considered one of America's best big cities, ranking ahead of New York City, in Conde Nast Traveler's 32nd annual Reader's Choice awards. The travel magazine surveyed 600,000 voters for their favorite cities in the U.S., adding more weight to San Diego's consideration.Readers celebrated America's Finest City for the region's food scene (which seems to be getting more and more recognition) and amusements for visitors of all ages. RELATED: Seven secret spots in San Diego to visit this summerOr as Conde Nast puts it: "San Diego has officially stepped out from the shadow of its big sister due north, earning world-class destination status that goes well beyond the waves."Tourist attractions are plentiful throughout San Diego County, with amusements in North County like the San Diego Zoo Safari Park and Legoland California down to the South Bay for Living Coast Discovery Center and Aquatica SeaWorld's Waterpark.Everywhere in between, the county's coastline offers more fun on the water or on land from Oceanside to Chula Vista. There is a reason San Diego is among the top cities for a staycation, with about 7% of hotel rooms purchased by locals looking to feel far from home.RELATED: 10 places to experience San Diego's nightlifeWhen it comes to in-county fun — and for free — there's no better way to explore than hiking through San Diego. This year, park rangers recommend visiting San Elijo Ecological Reserve, Flinn Springs County Park, and El Capitan County Preserve for a tranquil view of the East County.Rounding out the top five on the list were Washington, D.C. (5th); New Orleans, La.; Boston, Mass.; Minneapolis, Minn.; and Chicago, Ill. 1786

SAN DIEGO (KGTV) - University of California San Diego is the fifth best public university in the nation, according to U.S. News and World Report.The journal ranked colleges on criteria including research, global and regional reputation, international collaboration, doctorates awarded, and highly-cited papers.“UC San Diego is proud to receive this prestigious global recognition,” said Chancellor Pradeep K. Khosla. “As a premier public research institution – and one that is proud of non-traditional approaches to problem-solving – our excellence is driven by our bold research endeavors, interdisciplinary culture and solutions-driven scholars, who consistently make breakthroughs to benefit humanity.”UC San Diego was ranked the 17th best university in the world in a survey of 1,250 universities in more than 60 countries.Top programs cited by U.S. News and World Report include: 892

SAN DIEGO (KGTV) - With the lack of housing in San Diego, you need to act fast or you could miss out on a great home. Some San Diegans are getting proactive. They’re not waiting for a home to go up for rent; they’re reaching out to landlords before the property is even available. 10News is sharing a man's creative way to make it San Diego. All it takes is one breathtaking look and the appeal is undeniable. Orange Avenue, The Hotel Del, the Ferry Landing; they all make Coronado irresistible."Coronado is awesome. It's such a small-town feel. People say ‘hi’ to each other. You know your neighbors," said Cory Stock.Stock is a hard-working Surface Rescue Swimmer Instructor for the Navy. He doesn’t have a lot of time to research and look for a new place to live.RELATED: People converting vans to avoid high rent"Lots of swimming, lots of PT," said Stock.Work for Stock is either at Naval Base San Diego or at Naval Base Coronado right on the island. So, Stock decided Coronado would also be a great place to call home. But there was one problem."The turnaround of places is so quick here," said Stock.Knowing anything in his price range might get snatched up in a heartbeat, Stock decided to get proactive and created a post on the Coronado Happenings Facebook page. He was looking for a one or two bedroom rental no later than January 1. It didn't hurt that he threw in the part about being active duty Navy with excellent credit and references, and that he's also a handyman. RELATED: Think we're in a housing crisis? Try this city"The mere fact that you're in the military; it gives you a lot of credit right off the bat," said Stock.In Coronado, being in the military practically means you're already vetted. And it worked. Within weeks Stack and his girlfriend found an affordable home near work, right in the middle of paradise. "Facebook is so big now and social media,” said Stock. “It's a lot easier to get your name out that way to people you'll probably never meet rather than hoping you bump into somebody."Stock moves into his new place at the beginning of the new year. 2097