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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

SALT LAKE CITY — When a bill to require a woman seeking an abortion in Utah to have an ultrasound passed the State Senate, with every single woman lawmaker in the chamber 183

Puerto Rico was spared the brunt of hurricane-force winds from Dorian that tore through the British and US Virgin Islands Wednesday, flooding roads and leaving areas without power.But the threat is far from over for the mainland, with Dorian forecast to strengthen into a "powerful hurricane" as it heads toward Florida and other parts of the east coast.As of 8 p.m. ET, the eye of Hurricane Dorian was located roughly 50 miles northeast of San Juan with hurricane-force winds extending 15 miles from the center of the storm, CNN meteorologist Dave Hennen said.Wind gusts of up to 40 mph are possible over the next couple of hours, considerably lower than what was forecast, Hennen said."Some lingering showers are possible over Puerto Rico, but the strong bands are now pulling away from the Island into the Atlantic, where based on satellite and radar images, Dorian may be intensifying," he said. 911

Selling "Christmas ornaments" with images of Auschwitz does not seem appropriate. Auschwitz on a bottle opener is rather disturbing and disrespectful. We ask @amazon to remove the items of those suppliers. https://t.co/0uG2JG558e pic.twitter.com/ucZoTWPk1W— Auschwitz Memorial (@AuschwitzMuseum) December 1, 2019 324

SpaceX launched 60 more mini internet satellites late Monday, this time testing a dark coating to appease stargazers.It’s a “first step” compromise between SpaceX and astronomers fearful of having dark skies spoiled by hundreds and, eventually, thousands of bright satellites circling overhead.The Falcon 9 rocket blasted into a cold, clear night sky, recycled by SpaceX for its fourth flight. As the first-stage booster flew to a vertical landing on an ocean platform, the Starlink satellites continued hurtling toward orbit to join 120 similar spacecraft launched last year. Flight controllers applauded, and the launch commentator described the booster’s fourth touchdown as “awesome.” An hour later, all 60 satellites were free of their upper stage and making their own way in orbit. “It’s a beautiful sight,” the commentator observed.His Starlink fleet now numbering 180, SpaceX founder and chief executive Elon Musk plans to ultimately launch thousands of these compact flat-panel satellites to provide global internet service. Each spacecraft is just 575 pounds (260 kilograms).After the first Starlink batch of 60 was launched in May and the second in November, astronomers complained how the bright satellite chain was hampering their observations. In response, SpaceX came up with a darkening treatment to lessen reflectivity. The coating is being tested on one of the newly launched satellites.Jeff Hall, director of the Lowell Observatory in Flagstaff, Arizona, said the Starlinks have been just an occasional problem — so far — but noted the risk to stargazing will grow as the constellation expands and other companies launch their own fleets. He heads the American Astronomical Society’s committee on light pollution, space debris, and radio interference, and is working with SpaceX on the issue. The matter is on the agenda, in fact, at the society’s conference in Hawaii this week.“Anything that darkens the satellites is a step in the right direction,” Hall said in an email Monday. He said it’s too soon to know whether the dark coating will work, “but it definitely is just a first step and not enough to mitigate the issues astronomy will experience with the Starlinks.”The Starlinks are initially placed in a relatively low orbit of 180 miles (290 kilometeters), easily visible as a long, strung-out cluster parading through the night sky. Over a few months, krypton-powered thrusters raise the satellites to a 340-mile (550-kilometer) orbit. The higher the orbit, the less visible the satellites are from the ground, according to SpaceX. Even so, SpaceX said it’s supplying astronomy groups with the satellite coordinates in advance, so they can avoid the bright flyover times.Already established in launching satellites for others and making space station deliveries for NASA, SpaceX is among several companies looking to provide high-speed, reliable internet service around the world, especially in places where it’s hard to get or too expensive. Others include Jeff Bezos’ Amazon and OneWeb. SpaceX may start service later this year in the northern U.S. and Canada, then expand to the world’s most populated areas after 24 launches. 3170