宜宾割双眼皮手术哪好(宜宾脸大怎么微整形) (今日更新中)

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) - The FBI said a bank robber who held up a US Bank in Rolando last week struck again Friday in La Mesa. Surveillance photos show a man entering the Wells Fargo Bank inside the Vons grocery store at 8011 University Ave. in La Mesa just before noon. The man pretended to talk on his phone before demanding money from the teller, agents said. He also threatened “to shoot” if he didn’t receive money, according to the FBI. After approaching the first counter, the man approached several tellers in an effort to get more cash, said investigators. The man spoke to tellers Aug. 15 during the US Bank robbery inside the Vons at 6155 El Cajon Blvd. “Grab a bag. Start with your 100s. Put all the money in the bag and give it to me or I'm gonna [sic] shoot,” the man said, according to agents. A helicopter searched the area near the Wells Fargo Friday afternoon but could not find the man. La Mesa Police said the man is 5’8”, in his mid-20s to early 30s, and has a tattoo of a cross on his forearm. Anyone with information about the robberies was asked to call the FBI. 1088

SAN DIEGO (KGTV) — The Fourth of July is traditionally a fun-filled weekend for locals to enjoy delicious food and take in a fireworks show. And while the pandemic has put some limits on that, there are still ways to have fun safely.El Cajon and Poway are hosting fireworks displays and encouraging residents to practice social distancing by staying in their car or watching the show from a distance.The Del Mar Fairgrounds also continues to host delicious fair food weekends with Chicken Charlies, Roxy's, and many more delectable treats — all from the comfort of your car drive-thru style.Balboa Park is also reopening several museums with guidelines in place to keep visitors safe.(As a reminder, residents are encouraged to stay home if they feel ill and avoid large gatherings with people not from the same household. The county also requires residents to practice social distancing and wear a facial covering when within six feet of those not from the same household.)Balboa Park museum reopenings (Friday): Starting Friday, several Balboa Park museums will reopen with new sanitation and distancing guidelines in place. The Fleet Science Center, San Diego Natural History Museum, San Diego History Center, and more will welcome visitors back this weekend for months-long closures. More infoEl Cajon July 4 fireworks (Saturday): Locals in El Cajon will be able to catch fireworks over John F. Kennedy Park at 9 p.m. on July 4, though the park itself will be closed. The show will be visible over a wide area and city officials encourage residents to look up and enjoy the show from home safely. More infoPoway's July 4 fireworks (Saturday): Fireworks will launch from both Poway High School and Sportsplex in South Poway Business Park at 9 p.m. on July 4. The two locations will allow for a nearly 360-degree view of fireworks from the Sportsplex while allowing those who traditionally view the show near the high school to continue doing so. Tickets must be purchased to watch the show from Lake Poway's parking lot. More infoSan Diego County Fair food fun (Friday-Sunday): What's the July 4 weekend without some fair food? The Del Mar Fairgrounds is offering delicious bites from fair vendors Friday through Sunday from now until Sept. 7. Grab a bit from vendors like Chicken Charlies, Roxy's, Sugar Bear, and more! The fair is also hosting virtual exhibits showcasing student artwork, photography, and livestock shows. More info 2445

SAN DIEGO (KGTV) -- The cost of living in San Diego has become more burdensome over the last year, according to a new report from the Bureau of Labor Statistics. The bureau says that while prices fell 0.3 percent between May and July of this year, prices for consumer goods have risen 1.4 percent over the last 12 months. The cost of housing is up more than three percent since this time last year while food prices rose by a little more than one percent. Nationally, prices for consumer goods are up nearly 2 percent year-over-year. Also year-over-year, the price for fuel and utilities has risen by more than 6 percent, according to the bureau. 656

SAN DIEGO (KGTV) -- The firefighter who died fighting the El Dorado Fire has been identified as San Diego native Charles Morton.Morton died while fighting the San Bernardino County fire late Thursday.According to the U.S. Forest Service, Morton was born in San Diego and started his career in 2002 as a Corpsman with the California Conservation Corps at the Butte Fire Center in Magalia.RELATED: Firefighter dies while battling wildfire in Southern California sparked by gender reveal party“Charlie was a well-respected leader who was always there for his squad and his crew at the toughest times,” said U.S. Forest Service Chief Vicki Christiansen. “Our hearts go out to Charlie’s loved ones, coworkers, friends and the Big Bear Hotshots. We will keep them in our thoughts and prayers."The fire was sparked in early September by a pyrotechnic device used in a gender reveal party, the Associated Press reported. 920

来源：资阳报