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The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The Trump administration announced Thursday it is enacting new sanctions on Russia for its election meddling, a month-and-a-half after missing a congressionally mandated deadline.The Associated Press also reports that the administration has accused Russia of an ongoing, deliberate attempt to penetrate the US energy grid.The new punishments include sanctions on the Internet Research Agency, a Russian troll farm that produced divisive political posts on American social media platforms during the 2016 presidential election. Yevgeniy Viktorovich Prigozhin, a financial backer to the Internet Research Agency with deep ties to Russian President Vladimir Putin, is also included.Known as "Putin's chef," Prigozhin was indicted by special counsel Robert Mueller earlier this year for his involvement with the Russian troll farm.In total, the administration applied new sanctions on five entities and 19 individuals on Thursday, including Russians who posed as Americans and posted content online as part of the IRA's attempts to sow discord ahead of the presidential contest.The sanctions were applied through executive power as well as through the Countering America's Adversaries Through Sanctions Act, which Congress initially passed this summer hoping to pressure Trump into punishing Russia for its election interference.Trump signed the bill reluctantly in August, claiming it impinged upon his executive powers and could dampen his attempts to improve ties with Moscow.The measure imposed an October deadline on the administration to produce lists of individuals and entities that could be subject to potential sanctions, and a January deadline to impose them. The law required the administration to identify entities that conduct significant business with the Russian defense and intelligence sectors.The administration missed both by several weeks, claiming necessary work was underway at the State and Treasury Departments to complete the lists.The delay was seen as sign of Trump's unwillingness to punish Russia for its meddling, which he has downplayed in the past. Members of Congress expressed frustration that their law, which passed almost unanimously, wasn't being enacted.On Thursday, administration officials insisted the new measures weren't the end of their efforts to punish Russia."By no means will this constitute the end to our ongoing campaign to instruct Mr. Putin to change his behavior," a senior administration official told reporters.The-CNN-Wire 2485

The skies started darkening over Lake Charles, Louisiana, on Wednesday, as Hurricane Laura trekked toward the state.People planning to hunker down at home raced to a local home supply store.“My wife didn't want to travel this time,” said resident Robert Deboest. “So, we decided to go head on and kind of stick it out.”That includes Adam Johnson, who was busy buying plywood to cover the windows of his home.“It was like a sheet,” he said.Johnson moved to the Lake Charles area several years ago from Colorado. Laura will be the first hurricane he experiences.“[The] duplex I live in was built in 2015, so it should be pretty secure,” Johnson said.Others, though, feel far less secure.“I was going to stay because I didn’t have nowhere to go,” said resident Yvonne Lancto.However, local officials made arrangements at the Burton Coliseum Complex in Lake Charles for anyone wanting to evacuate, with the National Guard and dozens of buses ready to carry evacuees out of the danger zone and to shelter.Just a few days before her 77th birthday, Lancto chose to flee the storm.“I feel more safer now (sic),” she said, shortly before boarding a bus, “Because I was gonna have to drive - I was scared.”What is scaring a lot of people in Lake Charles is not just the potential for Category 4 winds from Hurricane Laura, but massive storm surge, especially along the coast – which can easily swamp the first floor of a building.Paul and Wanda Bertrand said that is why they are getting out of their home in coastal Cameron Parish.“I’m ready to get back you know,” Paul Bertrand said. “I just left and I’m ready to get back already.”His wife, Wanda, said their lives were far more important and hopes that evacuating will only be temporary.“Hopefully, this will be over soon,” she said, “and we can get back home and everything will be like it was normal.”It’s a normalcy that Hurricane Laura will put to the test. 1917

The Senate has passed its long-stalled legislation that would overhaul how sexual harassment complaints are made and handled on Capitol Hill and would hold members of Congress personally responsible for paying such settlements out of their own pockets.The legislation moved forward following a deal reached by Missouri Republican Sen. Roy Blunt and Minnesota Democratic Sen. Amy Klobuchar, and praised by leaders of both parties in the Senate.The bill now goes back to the House of Representatives, which passed its version in February and where the expectation is that there will be a conference committee to work out the differences between the two bills after Congress returns from its weeklong Memorial Day recess.The differences between the House's and Senate's versions of the legislation include the language used in describing when a member would be required to pay for settlements -- and when they would not -- and the reporting of settlements.California Republican Rep. Jackie Speier, one of the chief negotiators of the House's bill said that there is "disappointment" in Senate's bill among some members on both sides of the aisle in the House."We will go to conference and hopefully we can iron out some of those differences," Speier said Thursday on CNN's "New Day."There also is criticism of the Senate's bill among some outside advocacy groups, which have written to Senate Majority Leader Mitch McConnell and Senate Minority Chuck Schumer expressing concern that the House bill became essentially too watered down in the Senate's negotiations."This bill contains numerous provisions that are contrary to key principles we've previously articulated, falls short of an acceptable compromise, and may have unintended negative consequences," says a letter sent to Senate leaders signed by the American Civil Liberties Union, Equal Pay Today, The Leadership Conference on Civil and Human Rights National Women's Law Center and Public Citizen.Additionally, these groups say they see "significant differences" between the House and Senate bills and are "deeply concerned" that "neither senators nor key stakeholders have been given adequate time to fully vet the bill."Congressional sources tell CNN there are numerous areas that the discussion will center on when the two sides meet to work out a compromise.Among the chief areas of concern: The provision for members being held personally responsible in the Senate bill states that they have to pay out of pocket only for sexual harassment, not for any awards that may be ordered for sex discrimination or any other kind of discrimination. Some fear that could provide a loophole for members who are accused of harassment to settle with a victim for sex discrimination, knowing that they won't be required to pay the settlement and it will instead come out of a US Treasury fund.Additionally, there is concern that in the Senate's legislation would empower and involve the Ethics Committee more so than the House's. The Senate version would give the chair and ranking member of the committee the authority to overrule settlement repayments. The House bill would create a third-party investigatory process instead. 3183

The US Treasury Department is sanctioning Turkey's ministers of justice and interior in response to the detention of American pastor Andrew Brunson, White House press secretary Sarah Sanders said Wednesday."We've seen no evidence that Pastor Brunson has done anything wrong," Sanders said, calling Brunson's detention "unfair and unjust."The two ministers will have any assets and properties under US jurisdiction blocked and US persons will be prohibited from engaging in financial transactions with the ministers. 523