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BEIJING, Oct. 11 (Xinhuanet) -- An experimental drug that can remove amyloid plaques from the brains of Alzheimer's patients is being developed by Swiss Roche Holding AG in a small early-stage study, according to a report published in the Archives of Neurology on Monday.Researchers suspect the build-up of such plaques may be a cause of the memory robbing disease, although that theory has yet to be definitively proved. Gantenerumab, a biotech drug designed to bind to amyloid plaques in the brain and remove them, is being targeted at the early stages of Alzheimer's with the hope it can slow progression of the disease while patients are still able to function.The Phase I study of 16 Alzheimer's patients tested gantenerumab at two doses against a placebo over six months of treatment.The Roche drug led to a dose-dependent reduction of brain amyloid, while amyloid load increased in patients receiving a placebo, the report said.The next step will be to investigate whether removal of brain amyloid translates into clinical benefit for patients at doses of the experimental drug that are well tolerated and safe, the report said.Much larger trials and further study will be needed to fully understand how gantenerumab works and whether it can stave off Alzheimer's, said the report.Roche is approaching the disease far earlier because amyloid accumulates for 15 years before dementi.
WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."

XIAMEN, Dec. 26 (Xinhua) -- The three-decade achievements of the Xiamen Special Economic Zone have shown that China has made the right decision to set up special economic zones (SEZs), President Hu Jintao said Monday.Hu made the remarks in a congratulatory letter to a gala held Monday in southeastern Fujian province's city of Xiamen, which is celebrating the 30th founding anniversary of its special economic zone.Over the past 30 years, the Xiamen Special Economic Zone has made marked socio-economic progress, made significant changes in people's lives, and served as a pilot area for the country's reform and opening-up and socialist modernization, Hu said.The Xiamen Special Economic Zone has made a unique contribution to promoting cross-Strait economic and trade cooperation as well as culture and personnel exchanges, Hu said in the letter.Hu also urged the economic zone to further enhance the capability of independent innovation, ensure and improve people's well being, strengthen and make innovations in social management, and better serve the peaceful development of the cross-Strait relationship.He Guoqiang, a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, attended and addressed the gala.In his speech, He said the economic zone should develop high-end manufacturing business and a modern service industry, while speeding up the establishment of a market-oriented technology innovation system that integrates production with scientific research.The economic zone needs to make greater efforts in energy saving and emissions reduction as well as environmental protection by greatly developing a green and recycling-based economy, according to He.He also said that the economic zone should exert itself to increase the income of rural and urban residents, especially low-income residents, and meet people's basic requirements in terms of education and culture, employment, medical services and housing."Reasonable appeals of the people should be addressed, and behavior that undermines people's interests should be resolutely rectified," He said.In addition, He expects the Xiamen Special Economic Zone to thoroughly implement the cross-Strait Economic Cooperation Framework Agreement (ECFA) and further explore and enhance cooperation in finance and logistics with Taiwan, He said.The economic zone should also strengthen the development of direct flights, customs clearance and ports in order to facilitate direct exchanges across the Taiwan Strait, according to He.He also met with representatives of Hong Kong, Macao and Taiwan residents and overseas Chinese, who attended the gala.He said people from all walks of life in Hong Kong, Macao and Taiwan have long been active in investing, financing education and alleviating poverty in Fujian.They have not only shared the opportunities that the country's reform and development have brought forth and expanded their own enterprises, but also greatly boosted the country's socio-economic progress, He said."You are witnesses, participants and beneficiaries of the reform and opening up," He said to these representatives.The Xiamen Special Economic Zone is one of the four earliest SEZs set up after China initiated the reform and opening up in 1978. In 1984, it was expanded from the initial 2.5 square kilometers to 131 square kilometers. Last year, it was extended to span the entire city.
SAN FRANCISCO, Oct. 5 (Xinhua) -- Microsoft announced Wednesday that it will bring cable television content to its Xbox video game console over the upcoming holiday season, expanding the console into an entertainment hub.According to the company's press release, nearly 40 world- leading TV and entertainment providers such as HBO GO and BBC will stream their content through the Xbox Live service in more than 20 countries and regions.Users will be able to sift through shows online with the Kinect motion sensor device for Xbox 360 and Bing voice search, Microsoft said.To watch TV programs via Xbox as an alternate delivery system, customers have to already subscribe to the TV services and Microsoft's Xbox Live Gold service of 60 U.S. dollars per year."Today's announcement is a major step toward realizing our vision to bring you all the entertainment you want, shared with the people you care about, made easy," Microsoft said in the press release.Microsoft first entered the gaming console market in 2001 with the Xbox, the predecessor to the Xbox 360. The Xbox 360 currently competes with Sony's PlayStation 3 and Nintendo's Wii as the seventh generation of video game consoles.In June, Microsoft said 35 million people subscribed Xbox Live service around the world, spending an average of 60 hours a month playing games and watching movies and shows. Last year, the company integrated social networking features into Xbox Live, allowing users chat with each other while watching programs.
BEIJING, Oct. 10 (Xinhua) -- The State Council, or China's cabinet, announced on Monday it will tax all resource products starting Nov. 1, extending the resource tax on domestic sales of crude oil and natural gas from some regions to the entire country.The list of taxable resources widened from crude oil and natural gas to coal, rare earth, salt and metal from Nov. 1, according to the country's revised resource tax regulations.The expansion of the resource tax is part of China's efforts to encourage energy conservancy and limit environmental damage.Sales of crude oil and natural gas nationwide will be taxed at a rate between five and 10 percent of their sales value, according to the revised regulations.The regulations impose a sales tax ranging from eight (1.25 U.S. dollars) to 20 yuan per metric ton on coking coal and from 0.40 to 60 yuan per metric ton on rare earth ore.Taxes on other types of coal stood unchanged at 0.30 to five yuan per metric ton.The tax rate for other non-ferrous metals is set between 0.4 to 30 yuan per metric ton. Ferrous metals will be taxed at two to 30 yuan per metric ton.Taxes on precious non-metallic ore will be between 0.5 to 20 yuan per kg or per carat, while taxes on cheap non-metallic ore are set between 0.5to 20 yuan per metric or per cubic meter.China's current resource tax is levied based on production volume instead of sales value, thus preventing the government from benefiting from energy and commodity price increases.Nonetheless, energy giants and mining companies such as PetroChina and Sinopec have enjoyed large profit margins on the sale of resources under the current tax scheme.A resource tax on oil and natural gas was introduced at a rate of five percent in northwest China's Xinjiang Uygur Autonomous Region on June 1, 2010 before being extended to 11 other provinces in December last year.
来源:资阳报