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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A San Diego man who mailed more than four pounds of pure methamphetamine to Guam inside stuffed animals and had more than 500 counterfeit credit cards in his possession was sentenced to 15 years in federal prison, the U.S. Attorney's Office announced Thursday.Daniel Wayne Gorman, 33, pleaded guilty to sending four packages from a Jamul post office in 2016, each containing a stuffed animal filled with methamphetamine, according to the U.S. Attorney's Office.The packages were mailed under the alias "Daniel German" and were intercepted in Barrigada, Guam, prosecutors said.He was sentenced Monday to 10 years for his plea to distribution of methamphetamine and five years for possession of counterfeit access devices stemming from fake credit cards and driver's licenses discovered at his home during a 2018 police search.Investigators found more than 500 counterfeit cards, along with "multiple fake Florida driver's licenses bearing the defendant's photograph but the personal identifying information of others," according to the U.S. Attorney's Office.Many of the credit cards also bore the names of real individuals who were not Gorman, prosecutors said. 1187

SAN DIEGO (CNS) - Flames tore through a Mira Mesa home Wednesday afternoon, causing extensive damage, injuring a firefighter and displacing five residents.The blaze erupted for unknown reasons shortly before 2 p.m. in the 10100 block of Embassy Way, just west of Camino Ruiz, the San Diego Fire-Rescue Department reported.All the occupants of the house were able to safely get outside prior to the arrival of emergency crews, according to SDFRD public affairs.Watch firefighters battle the fire below:Firefighters arrived to find the residence engulfed in flames. It took the personnel about 15 minutes to gain control of the blaze.Medics took one of the firefighters to Sharp Memorial Hospital for treatment of heat-related trauma.The American Red Cross was called in to help the displaced residents, all adults, arrange for interim shelter. 850

SAN DIEGO (CNS) - An alleged drunken driver accused of running over and fatally injuring a co-worker, who was trying to prevent her from driving home following a night out in Kearny Mesa, was charged Tuesday with murder, gross vehicular manslaughter while intoxicated and hit-and-run causing death. Latisha Ingram, 33, is accused in the death last Thursday night of 25- year-old Ha Minh Ta.Deputy District Attorney Phillippa Cunningham said Ingram was charged with second-degree murder because she has a 2010 DUI conviction in Orange County.According to the prosecutor, Ingram and Ta met up with other co-workers for after-dinner drinks and the defendant, ``against the advice of friends,'' decided to try and drive home.RELATED: San Diego police: Man run over, killed after argument in Kearny Mesa parking lotIngram got into an argument with Ta about 11:30 p.m. in a parking lot in the 4600 block of Convoy Street, and she allegedly started to drive away while he was still holding onto her car. Ingram drove out of the parking lot and turned southbound onto Convoy Street, where Ta let go and was run over by the defendant, San Diego police Officer Robert Heimsthe officer alleged.Paramedics rushed Ta to a hospital, where he died from his injuries. Ingram was arrested a short time later.Laboratory tests are pending to determine her blood-alcohol content at the time of her arrest, Cunningham said.San Diego Superior Court Judge Jay Bloom set bail at .5 million for Ingram, who pleaded not guilty to the charges and s set to return to court July 15 for a readiness conference. 1590

SAN DIEGO (CNS) - A motorist was killed when his car was struck by a trolley after he drove past a trolley crossing gate in the Valencia Park area, police said Tuesday.The crash happened around 11:45 p.m. Monday near the intersection of Merlin Drive and Imperial Avenue, east of Valencia Parkway, San Diego police Officer John Buttle said.A 22-year-old man was driving a Toyota Prius southbound on 60th Street toward Imperial Avenue when he drove past trolley crossing arms and was struck by an eastbound trolley, Buttle said. The impact pushed the vehicle about 100 feet down the tracks.The victim, the only occupant of the Toyota, was pronounced dead at the scene, the officer said. The man's name was withheld pending family notification. 749

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