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SAN DIEGO (KGTV) — Apple says it will temporarily close all of its California storefronts, as the number of coronavirus cases surge in the state, according to multiple media reports.The company's Golden State locations, including stores in Carlsbad, Chula Vista, Escondido, and two in San Diego, were all listed online as "temporarily closed" on Saturday.Apple says each store will be open for pickup of existing online orders, previously scheduled in-store Genius Support appointments, and previously reserved one-on-one shopping appointments made through Tuesday, Dec. 22.No date was listed online for when the stores would fully reopen.The closures come as California continues to see a surge in COVID-19 cases. Both the Southern California and San Joaquin Valley regions hit 0% ICU bed capacity and the state reported more than 43,600 new virus cases on Saturday. 875

SAN DIEGO (KGTV) -- At least four people were stabbed in a brawl that erupted following a car show in Kearny Mesa early Thursday morning.San Diego police said the incident happened at a Chevron gas station in the 7700 block of Copley Park Place just after 12 a.m.According to police, about 50 people appeared at the gas station following a car show at a nearby park. During the gathering, a fight broke out, and a male pulled out a handgun and fired several gunshots.At the same time, another male used a knife to slash the tires of several vehicles and then tried to stab another male.When officers arrived at the gas station, those involved in the reported incident fled the area. Police discovered shell casings and blood at the scene.A short time later, police learned two people with stab wounds arrived at a Kaiser Permanente facility on Clairemont Mesa Boulevard. Both victims were then transferred to Sharp Memorial Hospital for treatment.Police learned two more people with stab wounds showed up at Scripps Memorial Hospital in La Jolla.According to police, the victims were between age 16-21. The victims described the suspect as a Hispanic male.No arrests have been made. 1190

SAN DIEGO (KGTV) - Crowds gathering at Veterans Park in Ocean Beach may face fines if they don't follow the county's public health orders.Tuesday morning, city crews put up orange mesh fencing around the park, but a few hours later, witnesses took pictures of two men cutting the fence down.Residents and business owners have been complaining for weeks about large groups gathering on Wednesday evenings gathered to watch the drum circle and hang out in the park.Mark Winkie is the president of the Ocean Beach Town Council. He didn't agree with shutting down the park, but he didn't condone tearing down the fence, either."Disappointing what happened here this morning, but it's important for people to know, as a town council, we really would like education to come first, to notify people about what they need to do when gathering here on such large quantities on a Wednesday," said Winkie.The public health orders banning gatherings of more than ten have been in place for months, but Winkie said it's possible not everyone is aware."Particularly for the drum circle, no city or county official has been out really interfacing with them, SDPD definitely came out, and I applaud their actions," said Winkie.Last week, police broke up the crowd, but did not issue citations.Councilmember Dr. Jennifer Campbell said it's time for enforcement."Everyday more San Diegans are dying, so we have to get tough and I'm telling you if this situation that happened last Wednesday night, happens this Wednesday night, there's gonna be a lot of clamp down, so they have got to stop it," Dr. Campbell said shouting.Violators could be fined up to ,000."By God, that is now the law and, therefore, the county sheriff should be out here arresting people who aren't wearing masks, who aren't distancing, and who are coming together," said Dr. Campbell.It's unclear if the city will put up a more permanent barrier or if anything will be in place by Wednesday evening. 1962

SAN DIEGO (KGTV) — Craft beer has a special hold on San Diego, not just locally but internationally as well.Which it's no surprise the region uses more than a week every year to celebrate the contributions brewers have made to San Diego.From Nov. 2 - 11, local craft beer fans can visit participating restaurants, bars, and breweries for special beer releases and events highlighting why San Diego is considered the capital of craft beer.RELATED: Brewery with restaurant and recreation coming to La MesaThe San Diego Brewers Guild kicks things off with Guild Fest, where more than 60 breweries will crowd Embarcadero South to showcase new and favorite brews.The rest of the week is filled with chances for San Diegans to try what's new with beer releases, special food and beer pairings, brewery tours, and special festivals.What better way to enjoy the fruits of the industry's labor in San Diego? San Diego's craft beer scene generated an estimated 1 million in 2015 and employed 4,512 workers, according to the San Diego Regional Economic Development Corporation.For a full list of events, visit San Diego Beer Week's website. 1165

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526