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Update, Mon. Oct. 28, 6:55 p.m.: The southbound lanes of the 405 reopened to traffic.LOS ANGELES (CNS) - Driven by gusting winds and dry terrain, a brush fire swept through canyons and hillsides on the western side of the Sepulveda Pass Monday, destroying at least eight homes, forcing evacuations of thousands of residents and closing part of the heavily traveled San Diego (405) Freeway. There were no immediate reports of any injuries. As of Monday afternoon, roughly 1,100 firefighters were assigned to the blaze, assisted by water-dropping aircraft. 563

U.S. government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalized with COVID-19 because it doesn’t seem to be helping them.Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue. But on Monday, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look did not verify a safety problem but found a low chance that the drug would prove helpful for hospitalized patients.It is a setback for one of the most promising treatment approaches for COVID-19. President Donald Trump received a similar experimental, two-antibody drug from Regeneron Pharmaceuticals Inc. on an emergency basis when he was sickened with the coronavirus earlier this month.In a statement Lilly notes that the government is continuing a separate study testing the antibody drug in mild to moderately ill patients, to try to prevent hospitalization and severe illness. The company also is continuing its own studies testing the drug, which is being developed with the Canadian company AbCellera.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. The experimental drugs are concentrated versions of one or two specific antibodies that worked best against the coronavirus in lab and animal tests.Lilly and Regeneron have asked the U.S. Food and Drug Administration to grant emergency use authorization for their drugs for COVID-19 while late-stage studies continue. Lilly says its request is based on other results suggesting the drug helps patients who are not hospitalized, and that it will continue to seek the FDA’s permission for emergency use.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 1928

Two studies recently published in the CDC’s journal indicate COVID-19 can spread on airplanes.In one study, researchers found a woman showing symptoms on a 10-hour flight potentially spread COVID-19 to at least 15 other people on the plane.A 27-year-old businesswoman who lived in London and was from Vietnam started having symptoms, fever and cough, while still in London in late February. She and her sister had visited Italy and other locations in London before the woman flew to Vietnam. Her sister later tested positive for COVID-19.The 27-year-old was one of 21 people sitting in business class on the March 1 flight from London to Hanoi, Vietnam. The woman became more sick once she landed, and isolated in her home. A few days later, she tested positive for COVID-19, as did three people in her house and a friend back in London she had visited before the flight.Researchers quickly tracked down the majority of people who were on the woman’s flight to isolate and trace potential cases.In all, researchers identified 14 additional passengers and one crew member who had COVID-19. The study states 12 of the passengers who tested positive had sat in business class with the 27-year-old woman, and 11 of them were sitting within two seats of her.“First, thermal imaging and self-declaration of symptoms have clear limitations, as demonstrated by case 1 (the woman), who boarded the flight with symptoms and did not declare them before or after the flight. Second, long flights not only can lead to importation of COVID-19 cases but also can provide conditions for superspreader events,” researchers concluded.The second study looked at four people aboard a flight from Boston to Hong Kong on March 9 who all tested positive for COVID-19 after landing in Hong Kong and showing symptoms. Two passengers, a couple, flew in business class. They showed symptoms the day they landed and sought healthcare.The other two cases were flight attendants who served the business class and first class sections of the plane. Both had come into close contact with the couple, and they both developed symptoms a few days after landing.Researchers were able to sequence their viruses and discovered all four had the same strain of COVID-19.Scientists conclude the couple contracted COVID-19 while they were in the U.S. and transmitted it to the flight attendants on the plane.“Passengers and cabin crew do not generally go through the same check-in process at airports before boarding. Although we cannot completely rule out the possibility that (the flight attendants) were infected before boarding, the unique virus sequence and 100% identity across the whole virus genome from the 4 patients makes this scenario highly unlikely,” researchers stated.Although there were no other positive COVID-19 cases reported from this flight, not all passengers were tested or tracked like in the first study.“Our results demonstrate that SARS-CoV-2 can be transmitted on airplanes. To prevent transmission of the virus during travel, infection control measures must continue,” they noted.Both of these studies looked at cases on flights before face coverings were mandatory on flights. They were published in Emerging Infectious Diseases, a journal of the Center for Disease Control and Prevention. 3286

UPDATE (9:39 p.m.): Jacob has been safely located, according to San Diego Police.SAN DIEGO (KGTV) — San Diego Police are searching for a missing teenager last seen in the Park West area near Balboa Park.Police say "Jacob" is 15 and diagnosed with autism. He is known to like the Balboa Park area where SDPD officers were searching late Thursday.Jacob is described as a white male, 5'11", weighing 160 pounds, and as having long brown hair. He was last seen wearing a tie-dye Led Zepplin shirt with blue jeans.Anyone with information is asked to call SDPD at 619-531-2000 or 858-484-3154. 595

VALLEY CENTER, Calif. (KGTV) - A North San Diego County resident resorted to Wild West measures after he was the victim of a crime, creating "Wanted: Dead or Alive" posters to find a thief.The San Diego Sheriff’s Office says approximately ,800 worth of items ranging from power tools to a mountain bike were stolen from a home on Valley Center Road on February 16.SDSO was working the case when the homeowner told deputies he had hung posters with the suspect’s image bearing ‘wanted dead or alive’ and the station’s number around town.“We don’t encourage vigilantism,” said Sgt. Russell Ryan.Ryan says SDSO asked the man to remove the posters but the man claimed he was exercising his first amendment rights.SDSO’s Valley Center substation took to Twitter to clarify they were, in fact, looking for the suspect but there was not a death warrant for alleged thief.Deputies were able identify the suspect as 23-year-old Jose Martinez, thanks to the homeowner's surveillance video. Martinez was taken into custody on Wednesday.Martinez is currently being held at the Vista Detention Facility on several burglary-related charges and is believed to be related to other recent thefts, according to SDSO.Sgt. Ryan says deputies have been able to recover the stolen bike and are searching for the other items. 1342