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SAN DIEGO (KGTV) — Mesmerizing works of art will hit San Diego's this Labor Day weekend as more than 300 tons of sand transform Broadway Pier into a sand sculptor's playground.From Aug. 31 to Sept. 2, the Port of San Diego will host the U.S. Sand Sculpting Challenge along the city's waterfront. This year's theme of "Wonder" will pay tribute to the Port's Wonderfront 2019 events, including Wonderspaces and Wonderfront music festival this November.The competition will feature 12 master sculptors from around the world to create museum-level quality sculptures out of nothing but sand. RELATED: San Diego's first-ever ice cream festival promises cool summer funThese pop-up works of art can reach up to 15 feet tall and weigh more than 20,000 pounds.Competitors will battle for more than ,000 in prize money and national pride. Returning this year will be 2018's grand prize winner Tom Koet from Melbourne, Fla., in addition to several U.S. competitors and other top talent from Canada, South Korea, the Netherlands, and elsewhere.In addition to the competition, visitors can check out an expanded kids zone with bounce houses, a bungie jump, and more, a giant sandbox where professionals will teach kids how to craft the perfect sand creation, live entertainment from several bands, and gourmet food trucks out and about.RELATED: Artists announced for Wonderfront music festivalA portion of proceeds will benefit local charities, including the Padres Foundation and e3 Civic High.Tickets are available online and special pricing is available for active-duty military and public safety personnel. Tickets cost for adults, for seniors 62 and older, for kids 2 to 12 years old, and are free for kids younger than 2 and under.For more information, visit the event's website online. 1801

SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - It has been yet another wild week of political news in San Diego. Congressman Duncan Hunter dominated our coverage for most of the week, and when accusations of misuse of campaign funds broke, we had an opportunity to get his side of the story from his father, former Congressman Duncan Lee Hunter. That did not sit well with some of our viewers. And for the first time, we were called "Fake News" from the left. Take a look for yourself in this week's Let's Talk. RELATED:  511

SAN DIEGO (KGTV) — It was an unforgettable Christmas surprise for 30 Tierrasanta elementary school students Friday.Officers from the San Diego Unified Police Department presented them with brand new bicycles.Most of the students from Hancock Elementary are part of military families and have a parent deployed this holiday season. RELATED: Padres players surprise San Diego elementary school students with new bikesThe gifts were part of the district's True Blue Buddies program, which pairs am officer as a mentor to a student."We're more than just a uniform," said officer John Ross. "We're people too, we have kids, but we want to make them feel good about the law enforcement connection."Originally, two students were awarded with bikes but then the remaining 28 got the surprise that they would be getting bikes too. 829

SAN DIEGO (KGTV) — It's no secret: exploring San Diego is a bit different amid county health orders and the COVID-19 pandemic. But there are still ways to explore safely! We're continuing our weekly look at fun around town with safety in mind.Here are four options for this weekend:Visit Old Town San Diego: While many of Old Town's smaller museums and shops remain closed, areas like the state park, Bazaar del Mundo, and nearby eateries are open for visitors. Businesses that have reopened are abiding by distancing, so guests can feel safe shopping in stores. The state park is also a great area to get some fresh air and distance. More infoCounty fair fun: The San Diego County Fair may be canceled this year, but the Del Mar Fairgrounds is continuing to highlight fair exhibits, foods, and more online and at the fairgrounds. Fair food vendors welcome guests Friday - Sunday throughout June for kettle corn, hot dogs, and more treats and the fair is hosting virtual exhibits showcasing student artwork, photography, and livestock shows. More infoHit the beach: San Diego County's beaches are open for laying out and relaxing, and parking lots, boardwalks, and piers have reopened. With warm temperatures lingering this week, it's the perfect time for a beach day. Just remember to wear a facial covering and practice distancing when near non-household members. More infoCheck out the San Diego Air and Space Museum: Balboa Park's first museum to reopen will be on Friday, as the San Diego Air and Space Museum welcomes guests with increased safety measures like stylus pens for hands-on exhibits, sanitation procedures, and distancing between guests. More info 1673