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WASHINGTON, June 21 (Xinhua) -- A new study from Harvard School of Public Health (HSPH) and University of California, San Francisco, researchers suggests that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. The study will be published Wednesday in the Journal of the American Medical Association."In our study, we found similar results for both prostate cancer recurrence and prostate cancer mortality," said Stacey Kenfield, lead author and a research associate in the HSPH Department of Epidemiology. "These data taken together provide further support that smoking may increase risk of prostate cancer progression."Kenfield and her colleagues conducted a prospective observational study of 5,366 men diagnosed with prostate cancer between 1986 and 2006 in the Health Professionals Follow-Up Study. The researchers documented 1,630 deaths, 524 (32 percent) due to prostate cancer, 416 (26 percent) due to cardiovascular disease, and 878 prostate cancer recurrences.The researchers found that men with prostate cancer who were current smokers had a 61 percent increased risk of dying from prostate cancer, and a 61 percent higher risk of recurrence compared with men who never smoked. Smoking was associated with a more aggressive disease at diagnosis, defined as a higher clinical stage or Gleason grade (a measure of prostate cancer severity). However, among men with non-metastatic disease at diagnosis, current smokers had an 80 percent increased risk of dying from prostate cancer.Compared with current smokers, men with prostate cancer who had quit smoking for 10 or more years, or who had quit for less than 10 years but smoked less than 20 pack-years before diagnosis, had prostate cancer mortality risk similar to men who had never smoked. Men who had quit smoking for less than 10 years and had smoked 20 or more pack-years had risks similar to current smokers."These data are exciting because there are few known ways for a man to reduce his risk of dying from prostate cancer," said senior author Edward Giovannucci, professor of nutrition and epidemiology at HSPH. "For smokers, quitting can impact their risk of dying from prostate cancer. This is another reason to not smoke."Prostate cancer is the most frequently diagnosed form of cancer diagnosed in the United States and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than two million men in the U.S. and 16 million men worldwide are prostate cancer survivors.

LOS ANGELES, Sept. 10 (Xinhua) -- Scientists at the University of California Los Angeles campus have announced that they have successfully used new prediction algorithms to forecast climate up to 16 months in advance.Professor Michael Ghil said in a UCLA news release Friday his team used new prediction algorithms based on matching ocean temperature records with new theories on how long-term climate trends are influenced by short-term weather extremes.That's twice as far into the future as previously accomplished.Ghil, a distinguished professor of climate dynamics in the UCLA Department of Atmospheric and Oceanic Sciences and senior author of the research, said the new prediction formulas will give climate experts and governments clues about long-term swings in the El Nino/La Nina oscillation in the Pacific Ocean, which drastically affects weather in the Americas, Asia and Australia.The new forecasting tool uses sea temperatures and has been tested on decades of historical data. The forecasts were then cross-checked against actual climate trends.The UCLA team also said that their 16-month forecasts were more accurate than previous forecasts that went only 8 months forward.Ghil emphasized that the forecasting tools are for climate, which is long-range, global patterns, but not for meteorology, which is short-term weather forecasting."Certain climate features might be predictable, although not in such detail as the temperature and whether it will rain in Los Angeles on such a day two years from now," said Ghil, who is also a member of UCLA's Institute of Geophysics and Planetary Physics. "These are averages over larger areas and longer time spans."The study is currently available online in the journal Proceedings of the National Academy of Sciences (PNAS) and will be published in an upcoming print edition of the journal.

BEIJING, Sept. 2 (Xinhuanet) -- Firefighters who worked in the wreckage of the World Trade Center in 2001 were 19 percent more likely to develop cancer than those who were not there, according to a study.The study, published Thursday in the British medical journal The Lancet, surveyed cancer occurrence in nearly 10,000 male firefighters in the seven years after Sept. 11, 2001. (There were too few women to create a meaningful sample size.)The 9/11 attacks occurred on Tuesday, Sept. 11, 2001. As a result, the World Trade Center collapsed, and nearly 3,000 Americans killed. Among the 2,753 victims killed in the World Trade Center were 343 firefighters.There were 263 cancer cases in the exposed population, showing a cancer rate 19 percent higher than that of the group not exposed.The study indicated that cancers like melanoma, non-Hodgkin’s lymphoma, thyroid and prostate cancer occurred more frequently among exposed firefighters than in the general population. But occurrences of lung cancer did not increase.The findings “provide information that there may be a significant cancer risk for these people”, said Dr. James Melius, the administrator of the New York State Laborers’ Health and Safety Trust Fund and one of the peer reviewers of the study.But the results were far from conclusive. “This is not an epidemic,” said Dr. David J. Prezant, a lead researcher and the chief medical officer for the New York Fire Department.

SINGAPORE, Sept. 7 (Xinhua) -- Singapore scientists have found possible new ways to treat a type of aggressive breast cancer that is unresponsive to current forms of treatment, local broadcaster Channel NewsAsia reported on Wednesday.The team of scientists at the Genome Institute of Singapore ( GIS) and National University of Singapore (NUS), led by GIS senior group leader Qiang Yu, found that the enzyme EZH2 acts by inhibiting genes that stop the growth of tumors in the body.The insights could open the door to developing more effective treatment for fast spreading breast cancers, especially the estrogen receptor-negative breast cancer that is common all over the world.It was also found that through EZH2, cancer is promoted in the body by activating specific genes that impact breast cancer progression and cancer stem cell self-renewal.Yu said the new understanding on how EZH2 works as a cancer- causing gene in breast cancer has important therapeutic implication."The results suggest that small molecule drugs that block enzyme activity of EZH2 may not work for cancers caused by EZH2's activation genes," Yu said.Currently pharmaceutical companies have been developing drugs only to the block EZH2 enzyme activity so that tumor suppressers can perform their protective role in blocking cancer growth.Researchers said the next step would be to develop biomarkers to identify tumors with EZH2.This step would enable better treatment methods, with one of options being the development of therapies that shut down EZH2 completely and not just inhibit its enzymatic function.The findings have been published on the journal Molecular Cell.

MOSCOW, Aug. 6 (Xinhua) -- The Arctic is getting warmer at a fast pace with the Russian Arctic sector's ice areas contracting to historically low levels, according to Russian meteorological bureau Rosgidromet.According to a Rosgidromet report cited by Itar-Tass news agency Saturday, the polar cap in the Russian sector has shrunk to the historical low registered in 2007, with no ice expected to block the Northern Seaway at least until September."Currently, Arctic navigation conditions are very favorable. By early August, navigation can be done without icebreakers almost along the entire route," said Valery Martyshchenko, head of Rosgidromet's environment pollution monitoring department.According to the Arctic and Antarctic Research Institute, the current ice cover in the Arctic Ocean is 6,860 million square kilometers, way below average.Martyshchenko said the longer period of icebreaker-free navigation would benefit the regions located in the Arctic area, allowing longer access to food and energy supplies, but the warming of the climate also posed new threats, such as melting of ice and forming of icebergs.

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