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SAN DIEGO (KGTV) - The images of our firefighters putting their lives on the line are striking; any time of the day or night and often just inches from raging flames, working to save us and our property.They sometimes pay a price.San Diego Fire-Rescue Capt. Dan King told reporters, "I just want to give perspective on what it's like to be a firefighter and to have cancer. Unfortunately, that's me. Two years ago today. I was in the middle of chemotherapy and radiation; pretty extensive treatment. For me, the treatment was very long and very painful."His remarks were during a news conference about a fund-raiser to upgrade the equipment at Firehouse 21 in Pacific Beach Tuesday.Imagine the health risks — every day."Firefighters can experience a lifetime of environmental exposures in a compressed period of time. It may happen at just one fire or, in many cases, chronic exposure over the course of a long career," Firefighter Kurtis Bennett, part of The Cancer Awareness and Prevention Program, said. To fight that the Pacific Beach Town Council wants to raise ,000 to augment city funding.San Diego City Council leader for District 2, Lorie Zapf, told the crowd, "I wish we had more revenue, more money so we could take care of all these equipment needs."Firehouse 21 would benefit directly. The hope is that other stations will, too, down the road."Their wish list has a health and safety theme; driven by the fact that 65 percent of firefighters develop some form of cancer," Denise Friedman, co-chair of the fundraising event, said.Capt. Rich Marcello showed 10News a specialized vacuum inside the station. He said it's a huge help to address immediate concerns."This extracts diesel particulates from the apparatus floor, which we're in quite a bit of the time and it hooks up to the exhaust system, extracts particles out and gets it out of our air," Marcello said.One hope is that other neighborhoods will find ways to reduce cancer risks for their firefighters as well. 2059

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) - The Coronado Police Department released an image Monday of a vehicle that may be related to BB gun incidents in Coronado Sunday. 10news has learned five people were struck in the downtown area. Police spent the morning scouring the ground near State Street and West Broadway. An officer told 10news four people were crossing State Street late Saturday night or early Sunday evening when three of them were hit. The extent of their injuries are unknown. At the corner of L Street and Sixth Avenue in the East Village, a woman was shot in the arm early Sunday morning, according to San Diego Police. She was walking in a small group and one of the men was an exhibitor at Comic Con, staying at the Omni Hotel, where they were headed before the shooting. The early morning shooting was not the only one that occurred overnight. In National City and Paradise Hills, at least a dozen cars were hit, and in Coronado, police said at least 23 businesses, homes an cars were struck by BBs.10news brought the image of a white sedan released by Coronado Police to Roman Beck, who has worked as an accident reconstruction expert for two decades."I believe it's a 2005 to 2010 Chrysler 300 sedan. It has the front, passenger and rear windows scrunched and a flattened roofline, along with similar roof structures and a flare around the wheelwell," said Beck.Coronado Police are asking anyone with surveillance cameras to check Sunday, July 21 from 1:30 a.m. to 2:30 a.m. Anyone with any information is asked to call (619) 522-7350.The rash of crimes comes after 10News reported more than a dozen businesses and car windows busted by BBs in the past month:June 24th – Numerous vehicle windows were vandalized in the Point Loma, Ocean Beach and Mission Hills neighborhoods.July 1st and July 2nd - Three businesses in the Hillcrest neighborhood were vandalized.July 2nd - Two businesses in the Park West neighborhood were vandalized.July 2nd and July 3rd – Numerous vehicle windows were vandalized in the Clairemont neighborhood.July 6th - Three businesses and one vehicle were vandalized in the Midway area. A dark colored SUV is suspected in these cases.July 7th - Five businesses in the College area were vandalized.July 8th - One home in the Lake Murray neighborhood was vandalized.July 21 - A woman was shot in the arm with a BB gun L Street and Sixth AvenueJuly 21 - Nearly two dozen businesses, homes and cars hit throughout CoronadoJuly 21 - Eight cars damaged on the 5800 block of Altamont DriveJuly 21 - Four cars damaged near East Plaza Blvd and Olive in National CityAccording to California law, negligent discharge of a BB gun resulting in injury could mean up to a year in jail.Police from the corresponding agencies are working on these cases. If you have any information or surveillance video, please contact your local department. 2862

SAN DIEGO (KGTV) - The family of a man killed in 2013 is pleading with the community for new leads as the case has now been left unsolved for more than half a decade.Ralph Green was killed on October 20, 2013.  He was murdered on Jewell Street in the Mountain View neighborhood, on the porch of his daughter’s home while at her 32nd birthday party.His daughter, Chanel Green, says the shooting happened suddenly, catching everyone by surprise.“My mother was on her way outside, so it was a blessing I didn't lose both my parents that day,” Chanel said. “I remember (my mother) shrieking, ‘oh my god, Ralph’s been shot.’ And I ran to the door to see my dad walk holding his neck.”Green says he was shot three times, once through this throat.“My brother catches him, and I moved my brother out of the way, and I laid (my father) down on the ground, and I start screaming, “oh my god, my dad’s been shot, call the police,’” she said. “My dad bled out on the floor, and all I could hope was that he heard me when I told him I loved him.” Channel’s aunt, Jennetta Pierce, was also shot.  Pierce is Ralph’s cousin-in-law.Pierce says she was inside the house, by the window, when the bullets started flying. One of them hit her on the lower back.“I got hit, but I didn’t let anyone know I got hit because my kids were there, and I just told them to get up under the table,” Pierce recalled.  After that, emergency crews came inside the house and took her to the hospital, where she spent two weeks.  She says she spent the next five years focused on moving forward.Police have said the shooting was random.  Chanel says there have been tips, and potentially leads given to the police but none have panned out.  But she’s convinced that there are people out there that know something, that can give her and her family the closure they need.“For anybody who knows somebody that knows something to come forward, now is the time, to tell the truth,” Chanel said. Anyone with information can contact San Diego Police or Crime Stoppers at 888-580-8477. 2087

SAN DIEGO (KGTV) — The City of San Diego will consider making a significant change to the way voting is done, best known as "ranked choice voting."It would allow voters to list up to four candidates in order of preference, rather than just cast a traditional ballot for one candidate."It's a very interesting system that hopefully decreases some of the negative campaigning that we ordinarily see," Councilmember Mark Kersey, who supports ranked choice, told 10News Friday.In the proposed version of ranked choice that San Diego is considering, the top four candidates in each primary race would advance to the general election, rather than the top two. In November, voters would then rank the candidates by preference. If one candidate has more than 50 percent of the vote on first count, that candidate would win. If no candidate reaches 50 percent, the last place finisher would be thrown out. That person's votes would then be reallocated according to the voters' second choice. The field would continue winnowing until a candidate tops 50 percent.UC San Diego political science professor Thad Kousser says ranked choice allows voters to feel like they are not wasting their vote on a long shot, and helps avoid the idea of voting for the lesser of two evils. "It allows voters to take a sincere vote without throwing away the weight that their vote would have," Kousser said.Kousser also says ranked choice helps keep races from getting as negative. "It could give candidates incentive to play nice with each other, to be less negative in their advertising beceause they would love to be second place on every voter's dance card," he added.Kersey says the City Council will consider placing ranked choice on the November ballot, with the goal of making the change in 2022. If the council elects not to put ranked choice on the ballot, supporters say they will launch a signature drive to get the measure on the ballot that way.Other cities in California have already adopted ranked choice, including San Francisco, Oakland, and Palm Desert. The concept is also gaining steam elsewhere in the country, with Maine moving to ranked choice for statewide elections."There's a reason why people are looking at doing it this way," Kersey said. "I think it's just a better way." 2283