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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.

BEIJING, Jan. 25 (Xinhua) -- A book collecting speeches made by Chinese President Hu Jintao during his state visit to the United States earlier this month has been published by the People's Publishing House.The book was distributed by Xinhua Bookstores Tuesday.

LOS ANGELES, March 18 (Xinhua) -- The moon will move closer to Earth than it has been in more than 18 years Saturday night, space. com reported on Friday.On Saturday afternoon at 3 p.m. Eastern Daylight Time (1900 MGT) , the "supermoon", as dubbed by some observers, will arrive at its closest point to the Earth in 2011: a distance of 221,565 miles ( 356,575 kilometers) away, and only 50 minutes earlier, the moon will officially be full, the report said.At its peak, the supermoon may appear 14 percent larger and 30 percent brighter than lesser full moons (when the moon is at its farthest from Earth), weather permitting, said the report.Yet to the casual observer, it may be hard to tell the difference, according to the report.Scientists say it is a fluke of orbital mechanics that brings the moon closer to Earth.The supermoon will not cause natural disasters, such as the Japan earthquake, NASA scientists say.In December 2008, there was a near-supermoon when the moon turned full four hours away from its perigee - the point in its orbit that is closest to Earth. But this month, the full moon and perigee are just under one hour apart, promising spectacular views, depending on local conditions, the report said.

WASHINGTON, May 1 (Xinhua) -- The launch of U.S. space shuttle Endeavour on its final voyage will be no earlier than May 8, after technical problems uncovered last week proved more complex than originally thought, the U.S. National Aeronautics and Space Administration (NASA) announced Sunday.NASA tried to launch Endeavour on Friday on its 25th and final flight to deliver the 2-billion-dollar Alpha Magnetic Spectrometer (AMS) particle detector to the International Space Station. AMS, a particle physics detector, is designed to search for various types of unusual matter by measuring cosmic rays. Its experiments are designed to help researchers study the formation of the universe and search for evidence of dark matter, strange matter and antimatter.The space shuttle Endeavour sits on launch pad 39A as work continues on the shuttle's auxilliary power unit at the Kennedy Space Center in Cape Canaveral, Florida May 1, 2011.However, the launch was called off after engineers detected a failure in one of two heater circuits associated with Auxiliary Power Unit (APU) 1. Heaters are required to keep the APUs' hydrazine from freezing on orbit.NASA hoped Endeavour would lift off on Monday. But further trouble-shooting indicated the glitch was more complicated than officials hoped initially.The failure appears to be a power problem within the aft load control assembly-2, a box of switches controlling power feeds."That basically means the power is not getting out to the heaters that weren't working on launch day," said Space Shuttle Program Launch Integration Manager Mike Moses.

BEIJING, Jan. 27 (Xinhua) -- The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities.The pilot reform will tax property owner-occupiers for the first time, officials from the Ministry of Finance, the State Administration of Taxation and the Ministry of Housing and Urban-Rural Development said Thursday.China's 1986 provisional property tax regulations did not tax owner-occupiers.The cities themselves will decide the details of the real estate levy. File photo taken on Apr. 23, 2010 shows residential areas in Shanghai, east China. The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities. Shanghai and Chongqing are cities that will trial the tax first. Shanghai sets its property tax rate at 0.4 to 0.6 percent. Municipalities impose property taxes on owners of real estate based upon the value of the property.Shanghai and Chongqing are cities that will trial the tax first.Shanghai set its property tax rate at 0.4 to 0.6 percent. Chongqing sets its at 0.5 to 1.2 percent.