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SAN DIEGO (KGTV) — The commissioner of the Pac-12 says 15-minute testing technology from a San Diego company could be the “game-changer” needed to restart competition in the conference before the end of the year.The Pac-12 is considering restarting college football as early as mid- to late-November, according to ESPN, as long as it can secure approvals from state and county lawmakers in California and Oregon.In some conferences, college football is entering its third week, but Pac-12 schools like USC and UCLA are still in workout mode after the conference voted last month to postpone all sports until 2021 at the earliest.League officials are now revisiting that decision and considering an earlier timeline after signing an agreement with San Diego-based Quidel Corporation to provide rapid antigen testing for all athletes, including daily tests for high-contact sports like football.“The access to rapid result testing that we can implement on even a daily basis with some sports with high contact will be a real game changer for us,” Pac-12 commissioner Larry Scott said after touring Quidel’s facility this month.Most nasal swab tests are genetic tests, or PCR tests, which seek out the genetic code buried inside the virus’ protein shell. These tests are considered the industry standard, but they require processing in a lab to convert RNA into enough readable strands of DNA. Results can sometimes take days.Quidel’s nasal swab test is what’s called an antigen test, which looks for parts of the virus’ protein shell. It can be read by machines at each university in about 15 minutes.“No one's going to be spreading the virus because no one will be engaging in practice or competition with the virus,” Scott said.That’s the hope at least, but the partnership with the Pac-12 will be an important test for Quidel’s diagnostic product.Quidel was the first company to get a rapid antigen test on the market, securing an emergency use authorization in May. But there were questions about the accuracy of the test compared to PCR tests in the small sample size provided by the company.In July, Quidel published more data showing its antigen tests matched up with PCR tests 96.7% of the time when a positive was detected. But those results were only among individuals who were actually showing symptoms.“The question that people have is in the asymptomatic population, will the data look similar?” said Quidel CEO Doug Bryant in an interview.Bryant said the company has unpublished data that will be forwarded to the FDA showing “very similar” relative accuracy to PCR tests in asymptomatic individuals, but he said the goal of the partnership with the Pac-12 is to investigate the tests even further.“We want to know that the tests we’re doing are appropriate for use in the asymptomatic population. And we need to demonstrate that, to not only the scientific community but to the public at large,” Bryant said.The testing program with the Pac-12 will essentially be a large clinical trial to find out if rapid testing of athletes can prevent spread, backed by the muscle at some of the premiere research universities.The Pac-12 is hoping the testing program will convince lawmakers to ease restrictions on college athletics, particularly in California.Although the NFL played a game at the new SoFI Stadium in Inglewood last weekend, nearby USC cannot gather in groups of more than 12 players.There are now four antigen tests on the market. Quidel plans to roll out its Sofia 2 testing machines to Pac-12 universities later this month. 3554

SAN DIEGO (KGTV) - The Department of Homeland Security is responding to the caravan of Central American immigrants prepared to enter the United States through the border with Mexico.At least 600 people from Guatemala, Honduras, El Salvador, and Nicaragua are traveling to Tijuana, according to freelance journalist Jorge Nieto. About 100 arrived last night. Eventually the group will enter the U.S. at the San Ysidro port of entry.Homeland Security Secretary Kirstjen Nielsen released a statement on the caravan.“DHS continues to monitor the remnants of the ‘caravan’ of individuals headed to our Southern border with the apparent intention of entering the United States illegally. A sovereign nation that cannot – or worse, chooses not – to defend its borders will soon cease to be a sovereign nation. The Trump Administration is committed to enforcing our immigration laws – whether persons are part of this ‘caravan’ or not.”DHS warned members of the caravan that they may be turned over for prosecution under illegal entry laws. Anyone seeking asylum may be detained while their claims are processed, DHS said.“Again, if you enter the United States illegally, let me be clear: you have broken the law. And we will enforce the law through prosecution of illegal border crossers,” Nielsen stated.The DHS statement encouraged those with asylum claims to seek protection in the first safe country they enter, naming Mexico as a possibility.“While we are committed to doing everything we can on the border to secure our nation, we need Congress to do their job as well.  I join the President in asking Congressional leadership to work with the Administration to pass legislation to close the legal loopholes that prevent us from securing our borders and protecting Americans. I stand ready to work with any member who in good faith seeks to support DHS’s mission and secure our country,” Nielsen wrote. 1914

SAN DIEGO (KGTV) - The coronavirus pandemic has put extra pressure and stress on families across San Diego. Now, experts worry that could be leading to a rise in child abuse."It's extraordinarily troubling," says Dr. Shalon Nienow, the Child Abuse Pediatrics Program's Clinical Director at Rady Children's Hospital's Chadwick Center."Since we started the pandemic, our volume has increased," Dr. Nienow says, noting that outpatient services are up 82% and inpatient treatment is up 75% since mid-March.Studies over the last decade have shown that economic struggles often lead to increases in child abuse. Nienow believes the Pandemic coupled with the economic downturn, has made it worse."People are isolated," Dr. Nienow says. "They don't have access to support services, and they're forced to take on roles they're not prepared for, such as being a teacher."The increased instances of child abuse and maltreatment may not be purely physical. San Diego County District Attorney Summer Stephan says her office has seen a dramatic increase in internet crimes against children during the pandemic. She says the amount has quadrupled since March."Kids are at home, they're on their tablets," Stephan explains. "On the internet, the predatory behavior of people trying to sexually exploit and recruit and get our kids to go into harm's way is really exploding... There is a direct correlation between kids being at home, out of school, out of their sports, and the increase of predatory and abusive crimes against them."Making matters worse, says Stephan and Dr. Nienow, is that the number of calls and reports of child abuse to Child Welfare Services has dropped dramatically since March.An ABC 10News Investigation in early April showed a nearly 60% drop in calls to CWS at the start of the pandemic. The county says now they're still seeing a 30% drop.In 2019, CWS fielded around 27,000 calls from April through August. In 2020, CWS took only approximately 19,000 calls."We certainly know families have more needs now than ever before and are struggling with all of the effects from the pandemic," says Dr. Kimberly Giardina, the Director of San Diego County Child Welfare Services.Experts believe the drop in calls is because kids are spending less time around teachers and doctors, who are legally required to report any signs of abuse they see."They tend to be a significant safety net for kids, and now that safety net is somewhat gone," says Dr. Nienow."Our teachers and counselors are the eyes and ears," adds Stephan. "They are the Safe Harbor."In their absence, the County and DA's office has launched training programs, which teach people how to recognize signs of abuse during online interactions like Zoom classes or telehealth visits. The county also authorized million in CARES Act funding to pay for community outreach and education.Stephan also sent a 7-page letter to Governor Gavin Newsom, detailing the scope of the problem. She asked him to take it into account when deciding whether or not to let schools reopen for in-person learning."I felt a responsibility that these alarming statistics become part of that conversation because the health of our kids and their safety has to be paramount," says Stephan.Dr. Giardina says Child Welfare Services is also working hard to make sure kids are safe. Their employees follow up on every call they receive and found ways to conduct in-person visits during the pandemic safely."We are out there," she says. "Our staff are working hard every day to make sure that those kids are safe."Experts all say it has become critical for parents, other family members, and neighbors to report any signs of abuse they see."Educate yourself," says Stephan. "Educate your children so that they can remain safe while we wait for our life to go back to normal and for kids to go back to school and to the safety of having those mandatory reporters.""It takes a village to raise healthy kids," says Dr. Nienow. "Especially now, when people are expected to deal with different stressors in their life, providing support to those families is really important."For more information, or to report suspected child abuse, call the County Hotline at 858-560-2191. You can also call 211.Within the state of California, you can call toll free, 1-800-344-6000. 4307

SAN DIEGO (KGTV) - The FBI’s Violent Task Crimes Force asked for the public’s help Monday to find a man known as the “Burgundy Bandit” and wanted for nine robberies in San Diego, La Mesa, and El Cajon.In each robbery, the man entered the business and approached an employee, flashing a gun hidden in his waistband, the FBI said in a news release.The man demanded money and walked away. On several occasions, the man cased the business five minutes before the hold-up, officials said.Robbery locations include:June 27: Fred Loya Insurance, El Cajon 555

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223